Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
F2 2147 MELAGATRAN CHEMBL266349 inhibitor GuideToPharmacologyInteractions
F2 2147 CHEMBL18136 CHEMBL18136 DrugBank 17139284, 17016423
F2 2147 CHEMBL38397 CHEMBL38397 DrugBank 17139284, 17016423, 10592235
F2 2147 SURAMIN CHEMBL265502 inhibitor DrugBank 15203120
F2 2147 PHENYLALANINE METHYL ESTER CHEMBL51969 DrugBank 10592235
F2 2147 CHEMBL220050 CHEMBL220050 DrugBank 10592235
F2 2147 CHEMBL379692 CHEMBL379692 DrugBank 10592235
F2 2147 CHEMBL282837 CHEMBL282837 DrugBank 10592235
F2 2147 4-HYDROXYPHENYLPYRUVIC ACID CHEMBL607712 DrugBank 10592235
F2 2147 CHEMBL1234624 CHEMBL1234624 DrugBank 10592235
F2 2147 ENOXAPARIN CHEMBL1201685 TdgClinicalTrial
F2 2147 LEPIRUDIN CHEMBL1201666 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 10912644, 11752352, 11807012, 11467439, 10505536, 11055889
F2 2147 CHEMBL46148 CHEMBL46148 DrugBank 10592235
F2 2147 CHEMBL433501 CHEMBL433501 DrugBank 10592235
F2 2147 CHEMBL96433 CHEMBL96433 DrugBank 10592235
F2 2147 CHEMBL327715 CHEMBL327715 DrugBank 10592235
F2 2147 CHEMBL123440 CHEMBL123440 DrugBank 10592235
F2 2147 CHEMBL204086 CHEMBL204086 DrugBank 10592235
F2 2147 CHEMBL141889 CHEMBL141889 DrugBank 10592235
F2 2147 CHEMBL401842 CHEMBL401842 DrugBank 10592235
F2 2147 CHEMBL282457 CHEMBL282457 inhibitor TdgClinicalTrial, TTD
F2 2147 DABIGATRAN ETEXILATE MESYLATE CHEMBL1615369 inhibitor ChemblInteractions
F2 2147 BIVALIRUDIN CHEMBL2103749 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 11060732, 11504570, 11923794, 11752352, 11929334, 11833835
F2 2147 DROTRECOGIN ALFA (ACTIVATED) CHEMBL2109065 DrugBank 12062545, 10463819, 12208873, 12070133, 12296618
F2 2147 MENADIONE CHEMBL590 activator TEND, DrugBank 6867080, 7657295, 10469489, 2484931, 2922761
F2 2147 ARGATROBAN CHEMBL1166 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 10226408, 10608016, 11752352, 10362188, 10353669, 10608050
F2 2147 PROFLAVINE CHEMBL55400 DrugBank 7837275, 6722124, 7407200, 4857231, 10592235, 1711542
F2 2147 XIMELAGATRAN CHEMBL522038 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank, TTD 17319469, 11752352, 17516699, 17532684, 17688383
F2 2147 CHEMBL1162174 CHEMBL1162174 DrugBank 10592235
F2 2147 DIPYRIDAMOLE CHEMBL932 DrugBank
F2 2147 CHEMBL307440 CHEMBL307440 DrugBank 10592235
F2 2147 CHEMBL42039 CHEMBL42039 DrugBank 10592235
F2 2147 CHEMBL380589 CHEMBL380589 DrugBank 10592235
F2 2147 CHEMBL116597 CHEMBL116597 DrugBank 10592235
F2 2147 CHEMBL391640 CHEMBL391640 DrugBank 10592235
F2 2147 CHEMBL391737 CHEMBL391737 DrugBank 10592235
F2 2147 CHEMBL1230612 CHEMBL1230612 DrugBank 10592235
F2 2147 CHEMBL257543 CHEMBL257543 DrugBank 10592235
F2 2147 CHEMBL75691 CHEMBL75691 DrugBank 10592235
F2 2147 CHEMBL225664 CHEMBL225664 DrugBank 10592235
F2 2147 CHEMBL65273 CHEMBL65273 DrugBank 10592235
F2 2147 BENZO[D]THIAZOLE CHEMBL510309 DrugBank 10592235
F2 2147 TAMOXIFEN CHEMBL83 FDA
F2 2147 HEPARIN CHEMBL1909300 TdgClinicalTrial, TEND
F2 2147 CHEMBL27885 CHEMBL27885 inhibitor TdgClinicalTrial, TTD
F2 2147 NONACOG ALFA CHEMBL2109205 DrugBank 10499904, 10498586, 11019961, 10648407, 10499905
F2 2147 DABIGATRAN CHEMBL48361 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, TTD
F2 2147 DESIRUDIN CHEMBL1201662 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
F2 2147 CHEMBL290376 CHEMBL290376 inhibitor GuideToPharmacologyInteractions
F2 2147 CHEMBL490730 CHEMBL490730 DrugBank 10592235
F2 2147 CHEMBL46780 CHEMBL46780 DrugBank 10592235
F2 2147 CHEMBL100109 CHEMBL100109 DrugBank 10592235
F2 2147 CHEMBL125181 CHEMBL125181 DrugBank 10592235
F2 2147 THROMBOMODULIN ALFA CHEMBL2108653 inhibitor DrugBank 3013935
F2 2147 CONESTAT ALFA CHEMBL2108350 inhibitor DrugBank 11460008

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
F2 rs5896 TT warfarin dosage no in a Southern Brazilian population of European ancestry. This F2 variant is not associated independently with warfarin dose. However, when it was included in the multiple linear regression (after controlling for covariates), statistically significant results were obtained. Genotype TT is associated with decreased dose of warfarin as compared to genotypes CC + CT. 21320153 1184510348
F2 rs3136516 G warfarin dosage no Samples, genotypes and INRs from a cohort of 551 patients were used to derive an algorithm which was used to predict daily warfarin maintenance dose in a second cohort of 236 patients. Note: the authors state that "SNPs were tested for deviations from HWE using the chi-squared test, and for their association with the warfarin dose by Spearman correlation analysis using a *co-dominant* model." Allele G is not associated with dose of warfarin in people with heart valve replacement as compared to allele A. 25126975 1184757060