PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
SPI1	1	ETV1	1	pull down	Carrere S (1998)	1
NSMCE2	0	ETV1	1	enzymatic study	Potts PR (2005)	1
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
RFWD2	0	JUN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Bianchi E (2003), Yi C (2005), Lu G (2014), Li X (2015), Huttlin EL (2017), Zou S (2016)	7
MAPK8	3	NCOA3	3	enzymatic study	Wu RC (2004)	1
ATR	6	TERT	7	genetic interference	Xie L (2013)	1
UBE2I	0	ETV1	1	enzymatic study	Gocke CB (2005)	1
MAPK14	0	KAT2B	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pillai VB (2011), Pillai VB (2011), Pillai VB (2011), Pillai VB (2011)	4
NCOA2	2	CCND3	1	pull down	Lazaro JB (2002)	1
TP53	0	ETV1	1	genetic interference, genetic interference	Xie L (2013), Xie L (2013)	2
JUN	0	ETV1	1	pull down	Fuchs B (2003)	1
ATR	6	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down	Stauffer D (2007), Stauffer D (2007), Stauffer D (2007)	3
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
DET1	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Wertz IE (2004), Vitari AC (2011), Lu G (2014), Lu G (2014), Pick E (2007), Huttlin EL (2017)	7
RPS6KA5	2	ETV1	1	enzymatic study	Janknecht R (2003)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
STK40	4	RFWD2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Huttlin EL (2015), Huttlin EL (2017), Durzynska I (2017), Durzynska I (2017), Durzynska I (2017)	5
DET1	2	STK40	4	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8	3	EP300	36	enzymatic study	See RH (2001)	1
MAPK8	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study	Ishitani T (2003), Nishitoh H (1998), Derijard B (1994), Derijard B (1994), Yazgan O (2002), Tada K (2001), Meyer CF (1996), Cano E (1995), Cano E (1995), Trivedi AK (2007), Zhu F (2006), Zuniga A (1999), Zuniga A (1999), Higashimoto T (2008), Garcia-Guzman M (2000), Singhirunnusorn P (2005), Hofmann TG (2005), Lewis J (2004), Jeon YJ (2009), Yamashita M (2008), Ryoo K (2004), Abell AN (2005), Burns K (1998), Hirano T (2002), Gravestein LA (1998), Dadgostar H (2003), Han YH (2006), Kolluri SK (2003), Chen LY (2003), Manna SK (2010), Gallagher ED (2002), Liu HP (2011), Xia Y (1998), Funakoshi-Tago M (2005), Ho DT (2006), Wang J (2000), Choi HK (2011), Chang TS (2003), Yao K (2009), Chang TS (2003), Dai R (2000), Gupta S (1996), Gupta S (1996), Sundarrajan M (2003), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Lee KH (2005), Kadoya T (2005), Katagiri C (2006), Yao K (2007), Wu X (2007), Kato T (2008), Cavigelli M (1995), Katagiri C (2006), Choi BY (2005), Choi BY (2005), Yuan ZQ (2003), Phelan DR (2001), Eliopoulos AG (2006), Hayashi T (2007), Zhang J (2013), Li X (2002), Kendrick TS (2004), Holzberg D (2003), Grau R (2004), Hernandez M (2000), Hwang SG (2014), Larsson H (1999), Rausch O (1997), Morley SJ (2000), Ho JM (2002), Shkoda A (2012), Pop M (2004), Chang HY (1999)	76
HNRNPL	3	CCND3	1	affinity chromatography technology	Fei T (2017)	1
KAT2B	2	NCOA3	3	two hybrid, pull down	Korzus E (1998), Takeshita A (1997)	2
HNRNPL	3	NSMCE2	0	affinity chromatography technology	Fei T (2017)	1
TP53	0	TERT	7	genetic interference, genetic interference	Xie L (2013), Xie L (2013)	2
ATR	6	TP53	0	pull down, unspecified method, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, genetic interference	Fabbro M (2004), Kim ST (1999), Lin WC (2001), Wang X (2011), Lakin ND (1999), Rocha S (2005), Dodson GE (2006), Kim ST (1999), Xie L (2013)	9
MAPK3	4	JUN	0	enzymatic study	Pulverer BJ (1991)	1
RPS6KA5	2	EP300	36	affinity chromatography technology	Janknecht R (2003)	1
NCOA3	3	NCOA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu RC (2002), Lodrini M (2008), Lodrini M (2008)	3
MAPKAPK2	1	MAPK3	4	protein complementation assay, enzymatic study	Srivastav RK (2011), Coxon PY (2003)	2
RFWD2	0	ETV1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baert JL (2010), Vitari AC (2011), Vitari AC (2011), Lu G (2014), Huttlin EL (2015), Huttlin EL (2017)	6
MAPK8	3	ETV1	1	enzymatic study	Janknecht R (2001)	1
SPI1	1	JUN	0	pull down	Carrere S (1998)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
ETV1	1	TERT	7	genetic interference	Xie L (2013)	1
KAT2B	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Jin Y (2002), Wang H (2008), Zhao Y (2006), Roe JS (2006), Perez RE (2010), Tang Y (2006), Zhao LY (2003), Liu L (1999), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Harrod R (2003), MacPartlin M (2005), Chen H (1999), Kang H (2009)	15
MAPK14	0	NCOA3	3	enzymatic study, enzymatic study	Wu RC (2004), Gianni M (2006)	2
MAPK3	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Persons DL (2000), How PC (2011), Lin C (2011), Lin C (2011)	4
KAT2B	2	JUN	0	affinity chromatography technology	Tsai LN (2008)	1
TP53	0	MAPK14	0	protein complementation assay, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Srivastav RK (2011), Zhang S (2006), Mo JS (2010), Gong X (2010), Perfettini JL (2005), Perfettini JL (2005), Bulavin DV (1999), Bulavin DV (1999)	8
HNRNPL	3	NCOA2	2	affinity chromatography technology	Fei T (2017)	1
MAPK14	0	MAPK8	3	affinity chromatography technology	Chan PM (2008)	1
TP53	0	NCOA2	2	pull down	Miyamoto-Sato E (2010)	1
KAT2B	2	ETV1	1	pull down, affinity chromatography technology, pull down, enzymatic study	Goel A (2003), Goel A (2003), Goel A (2003), Goel A (2003)	4
MAPK3	4	ETV1	1	enzymatic study	Janknecht R (2001)	1
NCOA2	2	ETV1	1	enzymatic study	Goel A (2004)	1
EP300	36	ETV1	1	affinity chromatography technology, enzymatic study, enzymatic study	Goel A (2003), Goel A (2003), Goel A (2004)	3
MAPK14	0	RPS6KA5	2	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Tanoue T (2001), Bandyopadhyay S (2010), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	5
CCND3	1	ETV1	1	two hybrid	Wang J (2011)	1
NCOA2	2	ATR	6	affinity chromatography technology	Jung SY (2005)	1
MAPKAPK2	1	MAPK14	0	affinity chromatography technology, protein complementation assay, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rane MJ (2001), Srivastav RK (2011), Wang J (2011), Varjosalo M (2013), Rane MJ (2001), White A (2007), ter Haar E (2007), Varjosalo M (2013), Gum RJ (1999), Gum RJ (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	16
HNRNPL	3	ETV1	1	affinity chromatography technology	Fei T (2017)	1
MAPKAPK2	1	ETV1	1	enzymatic study	Janknecht R (2001)	1
ATR	6	ETV1	1	affinity chromatography technology, enzymatic study, genetic interference	Xie L (2013), Xie L (2013), Xie L (2013)	3
ETV1	1	STK40	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
JUN	0	UBE2I	0	two hybrid, enzymatic study	Goettlicher M (1996), Muller S (2000)	2
ETV1	1	DET1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK8	3	TP53	0	affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Hu MC (1997), Yin ZM (2004), Yin ZM (2004), Fuchs SY (1998), Topisirovic I (2009), Drago-Ferrante R (2008), Wang J (2000), Chang NS (2003), Fuchs SY (1998)	9
RFWD2	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dornan D (2006), Dornan D (2004), Dornan D (2004), Dornan D (2004), Dornan D (2004), Choi HH (2011), Yamada T (2013), Zou S (2016)	8
MAPK14	0	EP300	36	pull down, enzymatic study, affinity chromatography technology	Pillai VB (2011), Pillai VB (2011), Saha RN (2007)	3
MAPK14	0	ETV1	1	enzymatic study	Janknecht R (2001)	1
TP53	0	NCOA3	3	pull down	Lee SK (1999)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
MAPK14	0	MAPK3	4	affinity chromatography technology, protein complementation assay	Sanz-Moreno V (2003), Srivastav RK (2011)	2
HNRNPL	3	MAPKAPK2	1	affinity chromatography technology	Fei T (2017)	1
ETV1	1	NCOA3	3	affinity chromatography technology, enzymatic study	Goel A (2004), Goel A (2004)	2
NCOA3	3	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, imaging technique, two hybrid, enzymatic study, affinity chromatography technology, pull down	Pao GM (2000), Feng Q (2006), Demarest SJ (2002), Demarest SJ (2002), Arimura A (2004), Font de Mora J (2000), Wang F (2010), Yi P (2005), Chen H (1999), Yi P (2015), Yi P (2015)	11
MAPK8	3	SPI1	1	enzymatic study	Mao C (1996)	1
MAPK14	0	JUN	0	enzymatic study	Thakur N (2014)	1
NCOA2	2	EP300	36	affinity chromatography technology, two hybrid, enzymatic study	Askew EB (2010), Hong H (1999), Chen H (1999)	3
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15