PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NCOA1	6	ETS1	4	affinity chromatography technology	Myers E (2005)	1
NR3C1	2	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
NR3C1	2	CREBBP	29	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Almloef T (1998), Almloef T (1998), Fryer CJ (1998), Govindan MV (2010), Govindan MV (2010), Govindan MV (2010), Carruthers CW (2015)	7
NR3C1	2	JUN	0	pull down	Lerner L (2003)	1
ETS1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee S (2008), Lee S (2008), Kim E (2003), Zhu M (2014)	4
EWSR1	2	ETS2	1	bioid	Elzi DJ (2014)	1
NR3C1	2	NCOA3	3	affinity chromatography technology, pull down, unspecified method, bioid	Hsiao PW (2003), Zilliacus J (2001), Suino-Powell K (2008), Lempiaeinen JK (2017)	4
RFWD2	0	JUN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Bianchi E (2003), Yi C (2005), Lu G (2014), Li X (2015), Huttlin EL (2017), Zou S (2016)	7
NCOR1	9	NCOA3	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Li X (2002), Li X (2002), Li X (2002), Li X (2002)	4
CREBBP	29	FOS	0	pull down, affinity chromatography technology, two hybrid	Fan S (2002), Bossis G (2005), Patel D (1999)	3
ETS2	1	DET1	2	affinity chromatography technology	Carrero ZI (2016)	1
ETS2	1	ANKS6	1	affinity chromatography technology	Hein MY (2015)	1
ETS2	1	XPO1	8	affinity chromatography technology	Ohtani N (2003)	1
ETS2	1	MRPL14	0	affinity chromatography technology	Hein MY (2015)	1
SPI1	1	ETS1	4	pull down	Carrere S (1998)	1
EP300	36	TWIST1	0	affinity chromatography technology, pull down, pull down, genetic interference	Hamamori Y (1999), Hamamori Y (1999), Hamamori Y (1999), Hamamori Y (1999)	4
ETS2	1	VPS51	1	affinity chromatography technology	Hein MY (2015)	1
EWSR1	2	NCOA3	3	bioid	Elzi DJ (2014)	1
ETS2	1	ETS1	4	pull down	Basuyaux JP (1997)	1
DET1	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Wertz IE (2004), Vitari AC (2011), Lu G (2014), Lu G (2014), Pick E (2007), Huttlin EL (2017)	7
EP300	36	ETS2	1	genetic interference, unspecified method, pull down, pull down, affinity chromatography technology	Pastorcic M (2000), Foulds CE (2004), Jayaraman G (1999), Jayaraman G (1999), Matsuda S (2004)	5
XPO1	8	NCOA3	3	affinity chromatography technology	Kirli K (2015)	1
ETS2	1	ZMYND11	10	two hybrid, affinity chromatography technology, pull down	Wei G (2003), Wei G (2003), Wei G (2003)	3
FOS	0	NCOA3	3	pull down, affinity chromatography technology	Fauquier L (2008), Fauquier L (2008)	2
JUN	0	NCOR1	9	imaging technique	Subbaramaiah K (2007)	1
JUN	0	EWSR1	2	pull down, bioid	Fuchs B (2003), Elzi DJ (2014)	2
NCOR1	9	ZMYND11	10	affinity chromatography technology	Masselink H (2000)	1
ETS2	1	IMPACT	1	affinity chromatography technology	Hein MY (2015)	1
CREBBP	29	NCOA1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Sheppard HM (2001), Sheppard HM (2001), Sheppard HM (2001), Wu RC (2002), Torchia J (1997), Torchia J (1997), Matsuda S (2004), DiRenzo J (2000), Nakuci E (2006), Ruas JL (2005), Huang SM (2002)	11
NCOA3	3	ETS1	4	affinity chromatography technology	Myers E (2005)	1
NCOA1	6	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Lodrini M (2008), Lodrini M (2008)	2
NCOR1	9	EP300	36	affinity chromatography technology	Cowger JJ (2006)	1
NR3C1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amat R (2007), Wang W (2012), Kino T (2002)	3
GTF3C5	4	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
EP300	36	FOS	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang WM (2011), Pekarsky Y (2008), Wang C (2001)	3
POU5F1	0	ETS2	1	pull down, affinity chromatography technology	Ezashi T (2001), Ezashi T (2001)	2
ZFYVE9	5	ETS2	1	two hybrid	Colland F (2004)	1
JUN	0	ETS1	4	pull down, pull down	Logan SK (1996), Miyamoto-Sato E (2010)	2
ETS2	1	CDK10	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Kasten M (2001), Kasten M (2001), Kasten M (2001), Kasten M (2001)	4
SPI1	1	JUN	0	pull down	Carrere S (1998)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
TP53	0	NCOA1	6	two hybrid, pull down	Lee SK (1999), Lee SK (1999)	2
NR3C1	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sengupta S (2000), Sengupta S (2001), Sengupta S (2001), Sengupta S (2001)	4
TP53	0	EWSR1	2	affinity chromatography technology	Li Y (2012)	1
EP300	36	EWSR1	2	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
TWIST2	0	ETS2	1	affinity chromatography technology, affinity chromatography technology	Ansieau S (2008), Ansieau S (2008)	2
EWSR1	2	CREBBP	29	pull down, bioid	Araya N (2003), Elzi DJ (2014)	2
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
SPI1	1	ETS2	1	pull down	Carrere S (1998)	1
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
EWSR1	2	NCOR1	9	bioid	Elzi DJ (2014)	1
EP300	36	ETS1	4	genetic interference, unspecified method, pull down, pull down	Pastorcic M (2000), Foulds CE (2004), Jayaraman G (1999), Jayaraman G (1999)	4
NR3C1	2	NCOA1	6	pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Zilliacus J (2001), Kucera T (2002), Windahl SH (1999), Fryer CJ (1998), Needham M (2000), Li G (2006), Lempiaeinen JK (2017)	7
RFWD2	0	ETS1	4	enzymatic study	Lu G (2014)	1
FOS	0	DET1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ETS2	1	GTF3C5	4	affinity chromatography technology	Hein MY (2015)	1
ETS2	1	JUN	0	pull down, two hybrid	Basuyaux JP (1997), Basuyaux JP (1997)	2
EP300	36	GTF3C5	4	affinity chromatography technology	Mertens C (2008)	1
TWIST1	0	ETS2	1	affinity chromatography technology, affinity chromatography technology	Ansieau S (2008), Ansieau S (2008)	2
RFWD2	0	ETS2	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu G (2014), Lu G (2014), Lu G (2014), Lu G (2014), Hein MY (2015), Carrero ZI (2016)	6
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
NR3C1	2	ETS2	1	affinity chromatography technology	Mullick J (2001)	1
NCOR1	9	NCOA1	6	pull down	Stevens A (2003)	1
ERG	1	JUN	0	pull down, pull down	Verger A (2001), Verger A (2001)	2
NCOR1	9	CREBBP	29	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Cowger JJ (2006), Cowger JJ (2006), Cowger JJ (2006), Cowger JJ (2006)	4
NCOA1	6	FOS	0	pull down, two hybrid, pull down, pull down, affinity chromatography technology	Lee SK (2000), Lee SK (1998), Lee SK (1998), Fauquier L (2008), Fauquier L (2008)	5
TP53	0	TWIST1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Shiota M (2008), Shiota M (2008), Piccinin S (2012), Piccinin S (2012), Kotlyar M (2015)	5
XPO1	8	GTF3C5	4	affinity chromatography technology	Kirli K (2015)	1
ETS2	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee S (2008), Lee S (2008), Carrero ZI (2016)	3
SPI1	1	FOS	0	pull down	Carrere S (1998)	1
ETS2	1	CREBBP	29	unspecified method, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Foulds CE (2004), Foulds CE (2004), Jayaraman G (1999), Matsuda S (2004), Matsuda S (2004), Matsuda S (2004)	6
RFWD2	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dornan D (2006), Dornan D (2004), Dornan D (2004), Dornan D (2004), Dornan D (2004), Choi HH (2011), Yamada T (2013), Zou S (2016)	8
NCOA3	3	ETS2	1	affinity chromatography technology	Myers E (2005)	1
ETS2	1	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
FOS	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
NCOA3	3	CREBBP	29	two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Naltner A (2000), Wu RC (2002), Wu RC (2002), Kamei Y (1996), Naeem H (2007), Naeem H (2007), Torchia J (1997), Torchia J (1997), Torchia J (1997), Torchia J (1997), Takeshita A (1997), Wu RC (2004), Corkery D (2011), Yi P (2005), Ceschin DG (2011)	15
ZMYND11	10	TP53	0	affinity chromatography technology	Zhang W (2007)	1
NR3C1	2	NCOR1	9	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, bioid	Stevens A (2003), Schulz M (2002), Schulz M (2002), Ki SH (2005), Wang Q (2004), Wang Q (2004), Lempiaeinen JK (2017)	7
XPO1	8	ANKS6	1	affinity chromatography technology	Kirli K (2015)	1
TP53	0	NCOA3	3	pull down	Lee SK (1999)	1
ETS2	1	FOS	0	pull down	Basuyaux JP (1997)	1
ETS2	1	ERG	1	two hybrid, pull down	Basuyaux JP (1997), Basuyaux JP (1997)	2
NCOA3	3	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, imaging technique, two hybrid, enzymatic study, affinity chromatography technology, pull down	Pao GM (2000), Feng Q (2006), Demarest SJ (2002), Demarest SJ (2002), Arimura A (2004), Font de Mora J (2000), Wang F (2010), Yi P (2005), Chen H (1999), Yi P (2015), Yi P (2015)	11
NCOR1	9	ETS1	4	affinity chromatography technology	Myers E (2005)	1
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
NCOA1	6	ETS2	1	affinity chromatography technology	Myers E (2005)	1
TWIST1	0	TWIST2	0	affinity chromatography technology	Fu J (2011)	1
NCOR1	9	ETS2	1	affinity chromatography technology	Myers E (2005)	1
NCOA1	6	EP300	36	affinity chromatography technology, imaging technique, pull down, pull down	Matsuda S (2004), Wang F (2010), Kino T (2002), Nasrin N (2000)	4
ETS1	4	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
ETS1	4	CREBBP	29	unspecified method, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Foulds CE (2004), Foulds CE (2004), Yang C (1998), Yang C (1998), Giese K (1995), Tsai LN (2008)	6
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
ETS2	1	CTDP1	2	affinity chromatography technology	Hein MY (2015)	1
FOS	0	RFWD2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	4
TP53	0	NCOR1	9	affinity chromatography technology, imaging technique	Dohi Y (2008), Ali A (2013)	2
NCOA1	6	JUN	0	pull down, pull down, two hybrid, pull down	Lee SK (1999), Lee SK (2000), Lee SK (1998), Lee SK (1998)	4