PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ESRRG	2	PSMC5	4	two hybrid	Albers M (2005)	1
ESRRG	2	ARHGEF15	4	two hybrid	Albers M (2005)	1
PRKN	1	ESRRA	2	affinity chromatography technology, affinity chromatography technology	Ren Y (2011), Ren Y (2011)	2
ESRRA	2	PROX1	0	two hybrid	Albers M (2005)	1
ESRRA	2	DUT	1	two hybrid	Albers M (2005)	1
PPARGC1A	3	NRIP1	4	affinity chromatography technology	Rytinki MM (2009)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
SP1	0	ESRRA	2	pull down	Castet A (2006)	1
SP1	0	ESRRG	2	pull down	Castet A (2006)	1
NCOA1	6	PPARGC1A	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Puigserver P (1999), Puigserver P (1999), Puigserver P (1999), Puigserver P (1999)	4
ESRRG	2	SHTN1	2	two hybrid	Rolland T (2014)	1
ESRRG	2	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
NRIP1	4	ESRRA	2	pull down, pull down, two hybrid	Castet A (2006), Castet A (2006), Albers M (2005)	3
DNMT3L	2	ESRRG	2	imaging technique, pull down, affinity chromatography technology	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	3
ESRRG	2	DUT	1	two hybrid	Albers M (2005)	1
NRIP1	4	ESRRG	2	pull down, pull down, two hybrid	Castet A (2006), Castet A (2006), Albers M (2005)	3
ESRRG	2	NR0B2	1	pull down, affinity chromatography technology, pull down, two hybrid	Zhou T (2010), Zhang Y (2011), Park YY (2004), Park YY (2004)	4
ESRRG	2	EBP	1	two hybrid	Albers M (2005)	1
PSMC5	4	SP1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Su K (2000), Su K (2000), Wang YT (2008), Wang YT (2008)	4
ESRRG	2	KIFC3	3	two hybrid	Rolland T (2014)	1
ESRRG	2	NUP160	0	two hybrid	Rolland T (2014)	1
PRKN	1	PSMC5	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tsai YC (2003), Tsai YC (2003), Um JW (2010), Sarraf SA (2013)	4
NRIP1	4	APP	1	pull down	Olah J (2011)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
ESRRA	2	NCOA1	6	two hybrid, two hybrid	Chan CM (2013), Albers M (2005)	2
SRPK1	2	ESRRG	2	enzymatic study	Varjosalo M (2013)	1
NR0B1	2	ESRRA	2	two hybrid	Albers M (2005)	1
HGS	5	ESRRG	2	pull down	Pridgeon JW (2009)	1
KIFC3	3	APP	1	pull down	Olah J (2011)	1
ESRRG	2	391257	0	two hybrid	Rolland T (2014)	1
ESRRA	2	PPARGC1A	3	x-ray crystallography, two hybrid, pull down	Kallen J (2004), Huss JM (2002), Huss JM (2002)	3
NRIP1	4	NR0B1	2	two hybrid, pull down	Sugawara T (2001), Sugawara T (2001)	2
PRKN	1	ESRRG	2	affinity chromatography technology	Ren Y (2011)	1
ESRRG	2	APP	1	pull down	Olah J (2011)	1
ESRRG	2	DEUP1	0	two hybrid	Rolland T (2014)	1
KIFC3	3	DEUP1	0	two hybrid	Rolland T (2014)	1
ESRRA	2	ESRRG	2	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, imaging technique	Zhang Z (2007), Zhang Z (2007), Dufour CR (2007), Albers M (2005), Albers M (2005), Wang L (2008)	6
ESRRG	2	PNRC1	0	two hybrid	Albers M (2005)	1
PRKN	1	MEOX2	2	two hybrid	Corominas R (2014)	1
ESRRG	2	NR0B1	2	two hybrid, two hybrid	Albers M (2005), Rolland T (2014)	2
APP	1	PNRC2	0	pull down	Virok DP (2011)	1
SRPK1	2	APP	1	pull down	Olah J (2011)	1
EBP	1	APP	1	pull down	Olah J (2011)	1
ESRRG	2	NCOA1	6	pull down, two hybrid	Greschik H (2002), Albers M (2005)	2
PSMC5	4	ESRRA	2	two hybrid, two hybrid	Albers M (2005), Albers M (2005)	2
ESRRG	2	PPARGC1A	3	pull down, pull down	Liu D (2005), Wang J (2009)	2
ESRRG	2	PROX1	0	two hybrid	Albers M (2005)	1
ESRRG	2	ESRRG	2	x-ray crystallography, pull down, far western blotting, unspecified method, two hybrid	Greschik H (2002), Hentschke M (2002), Hentschke M (2002), Hentschke M (2003), Rolland T (2014)	5
ESRRG	2	TLE1	6	pull down, unspecified method	Hentschke M (2003), Hentschke M (2003)	2
ESRRG	2	PNRC2	0	two hybrid, pull down	Albers M (2005), Hentschke M (2003)	2
ESRRA	2	NR0B2	1	two hybrid	Albers M (2005)	1
ESRRG	2	MEOX2	2	two hybrid	Rolland T (2014)	1