Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ESR2 2100 TAMOXIFEN CHEMBL83 agonist, antagonist PharmGKB, TdgClinicalTrial, TEND, DrugBank 16326830, 11752352, 17404078, 16010412, 2011412, 20827267, 16822624, 17158759
ESR2 2100 TRILOSTANE CHEMBL1200907 allosteric modulator DrugBank 12209583, 16806905, 17109615
ESR2 2100 PRASTERONE CHEMBL90593 activator DrugBank 15994348
ESR2 2100 PRINABEREL CHEMBL450940 agonist ChemblInteractions, DrugBank 10592235
ESR2 2100 CHEMBL360410 CHEMBL360410 DrugBank 10592235
ESR2 2100 CHEMBL185918 CHEMBL185918 DrugBank 10592235
ESR2 2100 CHEMBL187105 CHEMBL187105 DrugBank 10592235
ESR2 2100 BAZEDOXIFENE CHEMBL46740 TdgClinicalTrial
ESR2 2100 EXEMESTANE CHEMBL1200374 PharmGKB
ESR2 2100 ESTROGEN CHEMBL592868 TdgClinicalTrial
ESR2 2100 DIETHYLSTILBESTROL DIPHOSPHATE CHEMBL1200598 agonist ChemblInteractions
ESR2 2100 IDOXIFENE CHEMBL6318 modulator ChemblInteractions
ESR2 2100 ESTROGENS, ESTERIFIED CHEMBL1201468 agonist ChemblInteractions
ESR2 2100 ESTROGENS, CONJUGATED CHEMBL1201649 agonist ChemblInteractions
ESR2 2100 QUINESTROL CHEMBL1201165 agonist ChemblInteractions
ESR2 2100 TOREMIFENE CITRATE CHEMBL1200675 modulator ChemblInteractions
ESR2 2100 ESTRAMUSTINE PHOSPHATE SODIUM CHEMBL1200721 modulator ChemblInteractions
ESR2 2100 CHF4227 CHEMBL3545355 modulator TdgClinicalTrial, ChemblInteractions, DrugBank
ESR2 2100 LASOFOXIFENE CHEMBL328190 DrugBank
ESR2 2100 CHEMBL192154 CHEMBL192154 DrugBank 10592235
ESR2 2100 CHEMBL184151 CHEMBL184151 DrugBank 10592235
ESR2 2100 CHEMBL367588 CHEMBL367588 DrugBank 10592235
ESR2 2100 CHEMBL364092 CHEMBL364092 DrugBank 10592235
ESR2 2100 CHEMBL236718 CHEMBL236718 DrugBank 10592235
ESR2 2100 CHEMBL1232445 CHEMBL1232445 DrugBank 10592235
ESR2 2100 ERTEBEREL CHEMBL278703 agonist ChemblInteractions, DrugBank 10592235
ESR2 2100 CHEMBL236086 CHEMBL236086 DrugBank 10592235
ESR2 2100 SIVIFENE CHEMBL307697 TdgClinicalTrial
ESR2 2100 RALOXIFENE CHEMBL81 TdgClinicalTrial, TEND
ESR2 2100 SR16234 (CHEMBL3545210) CHEMBL3545210 TdgClinicalTrial
ESR2 2100 EQUOL CHEMBL198877 agonist TdgClinicalTrial, ChemblInteractions
ESR2 2100 AFIMOXIFENE (CHEMBL489) CHEMBL489 TdgClinicalTrial
ESR2 2100 MK-6913 CHEMBL3545274 agonist TdgClinicalTrial, ChemblInteractions
ESR2 2100 OSPEMIFENE CHEMBL2105395 modulator TdgClinicalTrial, ChemblInteractions
ESR2 2100 CR 1447 CHEMBL3545092 agonist ChemblInteractions
ESR2 2100 DROLOXIFENE CHEMBL487 modulator ChemblInteractions
ESR2 2100 CHLOROTRIANISENE CHEMBL1200761 modulator ChemblInteractions
ESR2 2100 CHEMBL346455 CHEMBL346455 DrugBank 17139284, 17016423
ESR2 2100 ESTRIOL CHEMBL193482 agonist DrugBank 16199482
ESR2 2100 MF101 CHEMBL3545411 agonist TdgClinicalTrial, ChemblInteractions, DrugBank
ESR2 2100 CHEMBL236720 CHEMBL236720 DrugBank 10592235
ESR2 2100 CHEMBL190467 CHEMBL190467 DrugBank 10592235
ESR2 2100 FISPEMIFENE CHEMBL2107341 modulator TdgClinicalTrial, ChemblInteractions
ESR2 2100 BAZEDOXIFENE ACETATE CHEMBL2106615 modulator ChemblInteractions
ESR2 2100 SYNTHETIC CONJUGATED ESTROGENS, B CHEMBL1201467 agonist ChemblInteractions
ESR2 2100 AFIMOXIFENE (CHEMBL10041) CHEMBL10041 modulator ChemblInteractions
ESR2 2100 GENISTEIN CHEMBL44 DrugBank 17139284, 17016423, 10592235
ESR2 2100 CHEMBL1222035 CHEMBL1222035 DrugBank 17139284, 17016423, 10592235
ESR2 2100 CHEMBL363498 CHEMBL363498 DrugBank 10592235
ESR2 2100 CHEMBL211614 CHEMBL211614 DrugBank 10592235
ESR2 2100 ALENDRONIC ACID CHEMBL870 PharmGKB
ESR2 2100 FULVESTRANT CHEMBL1358 antagonist TALC, PharmGKB, ChemblInteractions
ESR2 2100 ESTRADIOL CHEMBL135 TdgClinicalTrial, TEND
ESR2 2100 RALOXIFEN CHEMBL1079109 TdgClinicalTrial
ESR2 2100 TOREMIFENE CHEMBL1655 TdgClinicalTrial
ESR2 2100 LY2245461 CHEMBL3545389 modulator ChemblInteractions
ESR2 2100 ACOLBIFENE CHEMBL68055 modulator ChemblInteractions
ESR2 2100 RALOXIFENE HYDROCHLORIDE CHEMBL1116 modulator ChemblInteractions
ESR2 2100 ESTROGENS, CONJUGATED SYNTHETIC A CHEMBL1201466 agonist ChemblInteractions
ESR2 2100 DIETHYLSTILBESTROL CHEMBL411 agonist DrugBank 19101832, 15123288
ESR2 2100 ANDROSTANEDIOL CHEMBL316048 agonist DrugBank 20557886
ESR2 2100 ESTROPIPATE CHEMBL1200980 agonist DrugBank 2011412, 17464340
ESR2 2100 ESTRAMUSTINE CHEMBL1575 DrugBank 14755680

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ESR2 rs4986938 CC leflunomide efficacy no rs4986938 and rs1256049 were in linkage disequilibrium. Genotype CC is not associated with increased response to leflunomide in women with Arthritis, Rheumatoid as compared to genotypes CT + TT. 21174621 827783488
ESR2 rs1256049 CC leflunomide efficacy no rs4986938 and rs1256049 were in linkage disequilibrium. Genotype CC is not associated with increased response to leflunomide in women with Arthritis, Rheumatoid as compared to genotypes CT + TT. 21174621 827783502
ESR2 rs944050 TT gemcitabine efficacy yes Associated with longer time to progression. Stats corrected with the false-discovery rate for candidate SNPs and Bonferroni method (p<0.05 was considered significant). Genotype TT is associated with increased response to gemcitabine in people with Pancreatic Neoplasms as compared to genotypes CC + CT. 22838950 981237838