PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
UCHL1	1	COPS5	0	two hybrid, affinity chromatography technology	Caballero OL (2002), Caballero OL (2002)	2
ERN1	1	OTUB1	0	affinity chromatography technology	Zhu X (2014)	1
RIPK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fearns C (2006), Taipale M (2012)	2
OTUB1	0	HSPA5	0	affinity chromatography technology	Scholz CC (2016)	1
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
ERN1	1	UCHL1	1	affinity chromatography technology	Zhu X (2014)	1
ERN1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Qiu Q (2013), Qiu Q (2013)	2
STUB1	4	TRAF2	1	affinity chromatography technology	Jang KW (2011)	1
ERN1	1	TAOK3	4	affinity chromatography technology	Yoneda T (2001)	1
TRAF6	0	UCHL1	1	affinity chromatography technology	Karim R (2013)	1
SYVN1	2	DERL1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schulze A (2005), Schulze A (2005), Ye Y (2005), Bernardi KM (2010), Huang CH (2013), van de Weijer ML (2014), Hosokawa N (2016)	7
HSP90AA1	7	TAOK3	4	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
DERL1	2	USP14	1	affinity chromatography technology	You H (2017)	1
TRAF6	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999), Mochida Y (2000), Fujino G (2007), Fujino G (2007)	5
SRPK2	1	ERN1	1	enzymatic study	Varjosalo M (2013)	1
HSPA5	0	STUB1	4	affinity chromatography technology	Hein MY (2015)	1
TRAF2	1	ERN1	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kaneko M (2003), Zhu X (2014), Chen TC (2014), Zeng T (2015)	4
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
ERN1	1	USP14	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Nagai A (2009), Nagai A (2009), Hyrskyluoto A (2014)	3
SYVN1	2	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Wu ZZ (2011), Wu ZZ (2011), Yamasaki S (2007), Yamasaki S (2007), Yamasaki S (2007), Yamasaki S (2007), Yamasaki S (2007), Namba T (2015)	8
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
UCHL1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu J (2008), Li L (2010), Ilic A (2017), Ilic A (2017)	4
SCGB2A2	0	ERN1	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	HSPA5	0	affinity chromatography technology	Bennett EJ (2010)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
STUB1	4	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kutuzov MA (2007), Hwang JR (2005), Gao Y (2010), Gao Y (2010)	4
HSP90AA1	7	HSPA5	0	affinity chromatography technology	Gano JJ (2010)	1
HSPA5	0	SEL1L	2	affinity chromatography technology	Inoue T (2016)	1
MYC	2	STUB1	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paul I (2012), Paul I (2012), Paul I (2012), Huang H (2017)	4
HSPA5	0	ERN1	1	pull down, affinity chromatography technology	Liu CY (2003), Yanagisawa K (2010)	2
DERL1	2	ERN1	1	affinity chromatography technology	Nagai A (2009)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
SEL1L	2	DERL1	2	affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013)	2
TP53	0	HSPA5	0	affinity chromatography technology, affinity chromatography technology	Sun Y (2007), Fogeron ML (2013)	2
LYPD4	1	ERN1	1	affinity chromatography technology	Huttlin EL (2017)	1
TAOK3	4	TRAF2	1	affinity chromatography technology	Yoneda T (2001)	1
ERN1	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhu X (2014), Zhu X (2014), Zhu X (2014), Zhu X (2014)	4
ERN1	1	ERN1	1	pull down	Liu CY (2003)	1
ERN1	1	26223	0	affinity chromatography technology	Zhu X (2014)	1
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
TP53	0	FBXO11	14	affinity chromatography technology, pull down, affinity chromatography technology	Abida WM (2007), Abida WM (2007), Abida WM (2007)	3
ERN1	1	COPS5	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Hsieh YH (2007), Oono K (2004), Oono K (2004)	3
TP53	0	ERN1	1	affinity chromatography technology	Namba T (2015)	1
DERL3	0	ERN1	1	affinity chromatography technology	Nagai A (2009)	1
SYVN1	2	HSPA5	0	affinity chromatography technology	Wu ZZ (2011)	1
SYVN1	2	ERN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao B (2008), Nagai A (2009), Namba T (2015), Namba T (2015)	4
WDYHV1	0	ERN1	1	affinity chromatography technology	Huttlin EL (2017)	1
ZNRF4	1	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
SEL1L	2	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Wu ZZ (2011), Hosokawa N (2008), Mueller B (2008), Christianson JC (2008), Huang CH (2013), Huang CH (2013), Huang CH (2013), Huang CH (2013), Fujimori T (2013), Iida Y (2011), Iida Y (2011), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), van de Weijer ML (2014), Zhang T (2015), Hosokawa N (2016), Hosokawa N (2016), Hosokawa N (2016), Schulz J (2017), Schulz J (2017)	22
TRAF6	0	PSEN1	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Powell JC (2009), Elzinga BM (2009), Elzinga BM (2009), Yan R (2013), Yan R (2013), Gudey SK (2014), Gudey SK (2014)	7
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
WDYHV1	0	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
ERN1	1	RNF13	0	affinity chromatography technology, affinity chromatography technology	Arshad M (2013), Arshad M (2013)	2
COPS5	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
COPS5	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Wang J (2006), Wang J (2006)	2
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
ERN1	1	PSEN1	11	affinity chromatography technology	Katayama T (1999)	1
ERN1	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Estornes Y (2014), Estornes Y (2014)	2
COPS5	0	USP14	1	two hybrid	Wang J (2008)	1
DERL1	2	UCHL1	1	affinity chromatography technology	You H (2017)	1
ERN1	1	MAP3K5	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Nishitoh H (2002), Chen TC (2014), Zeng T (2015)	3
UCHL1	1	HSP90AA1	7	affinity chromatography technology, pull down	Kabuta T (2008), Kabuta T (2008)	2
TP53	0	OTUB1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Sun XX (2011), Sun XX (2011), Sun XX (2011), Li Y (2014), Fernandez-Majada V (2016)	5
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
ERN1	1	SEL1L	2	affinity chromatography technology	Nagai A (2009)	1
ZNRF4	1	ERN1	1	affinity chromatography technology	Huttlin EL (2017)	1
ERN1	1	FBXO11	14	affinity chromatography technology	Zhu X (2014)	1
MYC	2	ERN1	1	genetic interference	Zhou Z (2014)	1
HSP90AA1	7	MAP3K5	1	affinity chromatography technology	Taipale M (2012)	1
ERN1	1	HSP90AA1	7	affinity chromatography technology, pull down	Marcu MG (2002), Marcu MG (2002)	2
TRAF2	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Nishitoh H (1998), Hoeflich KP (1999), Gan B (2006), Kolliputi N (2009), Fujino G (2007), Fujino G (2007), Wu Y (2006), Zhang H (2004), Hwang SG (2014), Yoon KW (2009), Yoon KW (2009)	11