PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDK7	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rossignol M (1997), Shiekhattar R (1995), Yee A (1995), Kershnar E (1998), Reardon JT (1996), Varjosalo M (2013)	6
BRCA1	7	5430	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Krum SA (2003), Scully R (1997), Scully R (1997), Chiba N (2001), Chiba N (2001), Krum SA (2003), Starita LM (2005), Woods NT (2012), Bennett CB (2008), Hill SJ (2014), Winton CE (2016)	11
BRCA1	7	EWSR1	2	affinity chromatography technology	Ertych N (2016)	1
ERCC3	3	CDK7	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Rossignol M (1997), Yee A (1995), Jeronimo C (2007), Jeronimo C (2007), Reardon JT (1996), Chen D (1999), Varjosalo M (2013), Huttlin EL (2017), Luo J (2015)	10
CDK7	0	CCNH	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Maekelae TP (1994), Maekelae TP (1994), Maekelae TP (1994), Maekelae TP (1994), Yee A (1995), Garber ME (2000), Garber ME (2000), Jeronimo C (2007), Reardon JT (1996), Liu J (1997), Cujec TP (1997), Epie N (2005), Bockstaele L (2006), Tassan JP (1995), Chen D (1999), Havugimana PC (2012), Poterszman A (1997), Nguyen VT (2001), Garrett S (2001), Pinhero R (2004), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Luo J (2015)	25
TAF10	0	5430	0	affinity chromatography technology	Kouskouti A (2004)	1
ERCC3	3	CCNH	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Jeronimo C (2007), Drapkin R (1996), Drapkin R (1996), Huttlin EL (2015), Huttlin EL (2017), Luo J (2015)	7
SPTA1	10	ERCC3	3	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
ERCC5	0	EWSR1	2	two hybrid	Lim J (2006)	1
GTF2H5	0	CDK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Varjosalo M (2013), Hein MY (2015)	3
NTHL1	1	ERCC5	0	pull down	Bessho T (1999)	1
SPTA1	10	ERCC5	0	affinity chromatography technology	Sridharan DM (2006)	1
PALB2	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang F (2009), Sy SM (2009), Zhang F (2009), Zhang F (2009), Zhang F (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Zhang F (2012), Johnson N (2013), Anantha RW (2013), Hill SJ (2014), Bleuyard JY (2012), Orthwein A (2015), Orthwein A (2015), Loke J (2015), Simhadri S (2014), Ma J (2012), Ma J (2012), Foo TK (2017)	22
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
CDK7	0	BRCA1	7	affinity chromatography technology	Moisan A (2004)	1
BRCA1	7	RAD51	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scully R (1997), Dong Y (2003), Dong Y (2003), Dong Y (2003), Wang Q (2001), Chen J (1998), Mok MT (2010), Scully R (1997), Scully R (1997), Johnson N (2013), Jung YS (2014), Jung YS (2014), Parameswaran B (2015)	13
BRCA1	7	HSPB1	2	affinity chromatography technology	Ertych N (2016)	1
BRCA2	6	PCNA	0	affinity chromatography technology	Brough R (2012)	1
BCL6	6	ERCC5	0	affinity chromatography technology	Miles RR (2005)	1
GTF2H5	0	GTF2H1	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
ERCC5	0	BRCA2	6	affinity chromatography technology, affinity chromatography technology, pull down	Trego KS (2016), Trego KS (2016), Trego KS (2016)	3
LRPPRC	7	ERCC5	0	affinity chromatography technology	Hein MY (2015)	1
TGS1	0	ERCC5	0	affinity chromatography technology	Hein MY (2015)	1
ERCC5	0	ERCC2	4	affinity chromatography technology, pull down	Iyer N (1996), Iyer N (1996)	2
5430	0	EWSR1	2	affinity chromatography technology	Dutertre M (2010)	1
EWSR1	2	PCNA	0	bioid	Elzi DJ (2014)	1
PCNA	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Jascur T (2011), Jascur T (2011), Dar A (2014), Terai K (2010), Higa LA (2006), Higa LA (2006)	6
GTF2H1	0	CCNH	3	biochemical, biochemical, affinity chromatography technology	Shiekhattar R (1995), Kershnar E (1998), Araujo SJ (2001)	3
BRCA2	6	RAD51	3	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sharan SK (1997), Lin HR (2003), Yu DS (2003), Yu DS (2003), Chen PL (1998), Chen PL (1998), Chen PL (1998), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sarkisian CJ (2001), Wong AK (1997), Wong AK (1997), Katagiri T (1998), Katagiri T (1998), Pellegrini L (2002), Tarsounas M (2004), Liu J (2001), Chen J (1998), Sharan SK (1997), Marmorstein LY (1998), Ohashi A (2005), Shivji MK (2006), Xia B (2006), Xia B (2006), Badie S (2010), Liu J (2010), Carreira A (2011), Chen CF (1999), Chen CF (1999), Chen CF (1999), Lee M (2011), Esashi F (2005), Esashi F (2005), Esashi F (2005), Thorslund T (2007), Thorslund T (2007), Esashi F (2007), Brough R (2012), Zhao W (2015), Chu WK (2015), Trego KS (2016), Trego KS (2016), Trego KS (2016), Trego KS (2016), Luo K (2016)	46
ERCC3	3	ERCC2	4	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Drapkin R (1994), Iyer N (1996), Iyer N (1996), Havugimana PC (2012), Stehling O (2012), Luo J (2015), Luo J (2015)	9
ERCC5	0	DTL	0	imaging technique	Han C (2014)	1
ERCC2	4	GTF2H1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Drapkin R (1994), Rossignol M (1997), Seroz T (2000), Luo J (2015), Luo J (2015)	5
GTF2H5	0	ERCC2	4	affinity chromatography technology	Hein MY (2015)	1
ERCC5	0	BRCA1	7	affinity chromatography technology, pull down	Trego KS (2016), Trego KS (2016)	2
ERCC3	3	GTF2H1	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Marinoni JC (1997), Rossignol M (1997), Jeronimo C (2007), Drapkin R (1996), Araujo SJ (2001), Havugimana PC (2012), Maru Y (1999), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	12
BRCA2	6	BRCA1	7	affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sarkisian CJ (2001), Reuter TY (2003), Dong Y (2003), Chen J (1998), Chen J (1998), Villarroel MC (2011), Kumaraswamy E (2007), Sy SM (2009), Sy SM (2009), Sy SM (2009), Johnson N (2013), Hill SJ (2014), Loke J (2015)	13
GTF2H1	0	5430	0	enzymatic study, biochemical, enzymatic study	Moisan A (2004), Yankulov K (1999), Parada CA (1996)	3
CDK7	0	ERCC2	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reardon JT (1996), Havugimana PC (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
ERCC3	3	ERCC5	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017)	2
CCNH	3	BRCA1	7	affinity chromatography technology	Moisan A (2004)	1
PALB2	3	BRCA2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Hayakawa T (2010), Zhang F (2009), Sy SM (2009), Zhang F (2009), Xia B (2007), Xia B (2006), Xia B (2006), Xia B (2006), Sy SM (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Zhang F (2012), Oliver AW (2009), Oliver AW (2009), Oliver AW (2009), Anantha RW (2013), Bleuyard JY (2012), Brough R (2012), Orthwein A (2015), Trego KS (2016), Trego KS (2016), Trego KS (2016), Simhadri S (2014), Byrd PJ (2016), Park JY (2014), Park JY (2014), Ma J (2012), Ma J (2012), Luijsterburg MS (2017), Luijsterburg MS (2017), Foo TK (2017)	32
PCNA	0	RAD51	3	affinity chromatography technology, imaging technique	Chen X (2016), Sato K (2016)	2
PALB2	3	RAD51	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Dray E (2010), Hayakawa T (2010), Zhang F (2009), Zhang F (2009), Xia B (2006), Anantha RW (2013), Bleuyard JY (2012), Trego KS (2016), Trego KS (2016), Trego KS (2016), Simhadri S (2014), Park JY (2014), Park JY (2014), Ma J (2012), Ma J (2012), Luijsterburg MS (2017), Foo TK (2017), Foo TK (2017)	18
GTF2H5	0	ERCC3	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Giglia-Mari G (2004), Giglia-Mari G (2006), Hein MY (2015), Huttlin EL (2017), Luo J (2015)	6
GTF2H1	0	ERCC5	0	affinity chromatography technology, pull down	Araujo SJ (2001), Gervais V (2004)	2
GTF2H1	0	RAD51	3	genetic interference	Horlbeck MA (2018)	1
5430	0	ERCC3	3	affinity chromatography technology	Fousteri M (2006)	1
ERCC5	0	RAD51	3	affinity chromatography technology, affinity chromatography technology, pull down	Trego KS (2016), Trego KS (2016), Trego KS (2016)	3
GTF2H5	0	CCNH	3	affinity chromatography technology	Hein MY (2015)	1
GTF2H5	0	ERCC5	0	affinity chromatography technology	Hein MY (2015)	1
ERCC6	6	5430	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Anindya R (2010), Fousteri M (2006), Fousteri M (2006)	3
ERCC5	0	PALB2	3	affinity chromatography technology, affinity chromatography technology	Trego KS (2016), Trego KS (2016)	2
CDK7	0	ERCC5	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Varjosalo M (2013)	2
ERCC5	0	PCNA	0	pull down	Gary R (1997)	1
SPTA1	10	ERCC2	4	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
SPTA1	10	ERCC6	6	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
CCNH	3	5430	0	enzymatic study, biochemical, enzymatic study	Chen R (2004), Nekhai S (1997), Lolli G (2004)	3
SPTA1	10	RAD51	3	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
5430	0	ERCC5	0	affinity chromatography technology, affinity chromatography technology, pull down	Fousteri M (2006), Sarker AH (2005), Sarker AH (2005)	3
PIDD1	5	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Logette E (2011), Logette E (2011), Logette E (2011)	3
PIDD1	5	ERCC5	0	affinity chromatography technology	Logette E (2011)	1
5430	0	PCNA	0	affinity chromatography technology	Kang H (2011)	1
HSPB1	2	ERCC5	0	two hybrid	Katsogiannou M (2014)	1
CCNH	3	ERCC2	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Drapkin R (1996), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	4
ERCC6	6	BRCA1	7	affinity chromatography technology, enzymatic study	Wei L (2011), Wei L (2011)	2
PIDD1	5	ERCC2	4	affinity chromatography technology	Logette E (2011)	1
CCNH	3	ERCC5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERCC6	6	ERCC2	4	affinity chromatography technology	Anindya R (2010)	1
ERCC6	6	ERCC5	0	affinity chromatography technology, far western blotting	Fousteri M (2006), Sarker AH (2005)	2
ERCC6	6	PCNA	0	affinity chromatography technology	Anindya R (2010)	1
CDK7	0	5430	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical, enzymatic study, enzymatic study, enzymatic study	Drapkin R (1996), Gegonne A (2008), Moisan A (2004), Pinhero R (2004), Ramanathan Y (2001), Larochelle S (2012), Larochelle S (2006), Nekhai S (1997), Pinhero R (2004), Rovnak J (2012), Lolli G (2004)	11
TAF10	0	ERCC5	0	affinity chromatography technology	Jeronimo C (2007)	1
ERCC6	6	ERCC3	3	affinity chromatography technology	Fousteri M (2006)	1