PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
5430	0	ERCC4	2	affinity chromatography technology	Fousteri M (2006)	1
ERCC1	1	MUS81	1	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Huttlin EL (2017)	2
ERCC1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Liccardi G (2014), Liccardi G (2014), Liccardi G (2014), Liccardi G (2014)	4
SPTA1	10	ERCC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sridharan D (2003), Sridharan DM (2006), Sridharan DM (2006)	3
FANCD2	3	ERCC4	2	affinity chromatography technology	Unno J (2014)	1
UHRF1	3	MSH2	4	affinity chromatography technology	Ferry L (2017)	1
SLX4	6	SLX1B	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Svendsen JM (2009), Svendsen JM (2009), Wan B (2013), Wan B (2013), Wan B (2013)	5
SLX1B	0	ERCC4	2	affinity chromatography technology	Svendsen JM (2009)	1
SLX4	6	ERCC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, biochemical, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Andersen SL (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Kim Y (2013), Wilson JS (2013), Wilson JS (2013), Wan B (2013), Wan B (2013), Wan B (2013), Perez-Oliva AB (2015), Schuster B (2013), Bogliolo M (2013)	20
NTRK1	1	ERCC4	2	affinity chromatography technology	Emdal KB (2015)	1
GYPB	0	FANCG	3	affinity chromatography technology	Huttlin EL (2017)	1
SPTAN1	9	FANCD2	3	affinity chromatography technology, affinity chromatography technology	Zhang P (2016), Zhang P (2016)	2
SLX4IP	3	ERCC4	2	affinity chromatography technology	Svendsen JM (2009)	1
5430	0	ERCC1	1	affinity chromatography technology	Fousteri M (2006)	1
UHRF1	3	MUS81	1	affinity chromatography technology, affinity chromatography technology, pull down	Tian Y (2015), Tian Y (2015), Tian Y (2015)	3
ERCC6	6	ERCC4	2	affinity chromatography technology	Anindya R (2010)	1
FANCA	5	FANCD2	3	affinity chromatography technology, affinity chromatography technology	Huard CC (2013), Huard CC (2013)	2
TADA2A	1	ERCC4	2	affinity chromatography technology	Krebs AR (2010)	1
TADA2A	1	5430	0	affinity chromatography technology	Krebs AR (2010)	1
SLX1A	0	ERCC4	2	pull down, pull down	Munoz IM (2009), Fekairi S (2009)	2
NTRK1	1	SPTAN1	9	affinity chromatography technology	Emdal KB (2015)	1
GYPB	0	ERCC4	2	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	ALYREF	0	affinity chromatography technology	Emdal KB (2015)	1
UHRF1	3	ERCC4	2	affinity chromatography technology	Tian Y (2015)	1
SLX1B	0	SLX4IP	3	affinity chromatography technology	Svendsen JM (2009)	1
NTRK1	1	VPS26A	0	affinity chromatography technology	Emdal KB (2015)	1
SUMO2	0	ERCC4	2	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
SLX4	6	SLX4IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012)	5
EGLN3	0	5430	0	affinity chromatography technology	Rodriguez J (2016)	1
SPTA1	10	FANCA	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sridharan D (2003), Sridharan DM (2006), Sridharan DM (2006)	3
USP45	3	ERCC1	1	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, enzymatic study, affinity chromatography technology	Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015)	6
EGFR	5	ERCC4	2	affinity chromatography technology	Liccardi G (2014)	1
SLX4	6	MSH2	4	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012)	4
SLX4	6	PLK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), So J (2015)	5
FANCA	5	MSH2	4	affinity chromatography technology	Huang M (2011)	1
PLK1	0	ERCC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Huttlin EL (2017)	3
FANCA	5	FANCG	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Garcia-Higuera I (1999), Park SJ (2004), Garcia-Higuera I (1999), Yagasaki H (2001), Gordon SM (2003), Park SJ (2004), Garcia-Higuera I (1999), Huber PA (2000), Kruyt FA (1999), Kruyt FA (1999), Reuter T (2000), Blom E (2004), Thomashevski A (2004), Waisfisz Q (1999), Waisfisz Q (1999), Gordon SM (2003), Meetei AR (2003), Taniguchi T (2002), Taniguchi T (2002), Otsuki T (2002), Medhurst AL (2001), Medhurst AL (2001), Medhurst AL (2001), Garcia-Higuera I (2000), Yan Z (2010), Taniguchi T (2003), Wilson JB (2010), Wilson JB (2010), Singh TR (2010), Collins NB (2009), Tremblay CS (2008), Wilson JB (2008), Jacquemont C (2007), Ling C (2007), Ling C (2007), Ciccia A (2007), Medhurst AL (2006), Hussain S (2006), Mi J (2004), Mi J (2004), Qiao F (2004), Qiao F (2004), Ferrer M (2004), Thomashevski A (2004), Meetei AR (2003), Meetei AR (2003), Adachi D (2002), Meetei AR (2003), Nakanishi K (2001), Qiao F (2001), Futaki M (2001), Xie Y (2000), Ren J (2001), de Winter JP (2000), Kuang Y (2000), Kuang Y (2000), Kuang Y (2000), Kuang Y (2000), Garcia-Higuera I (1999), Huang M (2011), Yan Z (2012), Yan Z (2012), Huang Y (2014), Huang Y (2014), Zhu B (2014), Ali AM (2012), Ali AM (2012), Ali AM (2012), Huttlin EL (2017), Tremblay CS (2009), Huard CC (2013), Karras GI (2017)	73
SLX4	6	ERCC1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Munoz IM (2009), Munoz IM (2009), Kim Y (2013), Huttlin EL (2015), Perez-Oliva AB (2015), Huttlin EL (2017), Schuster B (2013), Bogliolo M (2013)	12
NTRK1	1	UHRF1	3	affinity chromatography technology	Emdal KB (2015)	1
C10orf55	0	ERCC4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLX1A	0	ERCC1	1	pull down	Munoz IM (2009)	1
5430	0	XPA	1	affinity chromatography technology	Fousteri M (2006)	1
FANCD2	3	SLX4	6	affinity chromatography technology, imaging technique, affinity chromatography technology	Unno J (2014), Yamamoto KN (2011), Yamamoto KN (2011)	3
FANCG	3	SPTAN1	9	biochemical, two hybrid, affinity chromatography technology	McMahon LW (2001), Lefferts JA (2009), Lefferts JA (2009)	3
MUS81	1	PLK1	0	affinity chromatography technology	Matos J (2011)	1
XPA	1	ERCC4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UHRF1	3	ERCC1	1	affinity chromatography technology, affinity chromatography technology, pull down	Tian Y (2015), Tian Y (2015), Tian Y (2015)	3
GTF2H1	0	5430	0	enzymatic study, biochemical, enzymatic study	Moisan A (2004), Yankulov K (1999), Parada CA (1996)	3
FANCD2	3	FANCG	3	affinity chromatography technology	Wilson JB (2008)	1
NTRK1	1	5430	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PLK1	0	affinity chromatography technology	Emdal KB (2015)	1
VPS26A	0	ERCC4	2	biochemical	Havugimana PC (2012)	1
EGFR	5	PLK1	0	affinity chromatography technology	Tong J (2014)	1
SLX1A	0	MUS81	1	pull down, pull down	Munoz IM (2009), Fekairi S (2009)	2
XPA	1	ERCC1	1	two hybrid, pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Li L (1994), Li L (1994), Li L (1994), Nagai A (1995), Nagai A (1995), Wakasugi M (2009), Huttlin EL (2015), Huttlin EL (2017), Friboulet L (2013)	9
SLX4	6	MUS81	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Kim Y (2013), Wilson JS (2013), Wan B (2013), Wan B (2013), Wan B (2013), Rolland T (2014), Yu H (2011), Nair N (2014), Nair N (2014), Nair N (2014), Ouyang J (2015), Huttlin EL (2017), Schuster B (2013), Bogliolo M (2013)	21
EGLN3	0	PLK1	0	affinity chromatography technology	Rodriguez J (2016)	1
NFKBID	1	ERCC4	2	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	SLX4	6	affinity chromatography technology	Rodriguez J (2016)	1
USP45	3	ERCC4	2	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Perez-Oliva AB (2015)	2
SLX4	6	SLX1A	0	two hybrid, pull down, pull down, biochemical, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Fekairi S (2009), Fekairi S (2009), Kim Y (2013), Wan B (2013), Wan B (2013), Wan B (2013)	11
ZFC3H1	6	ERCC1	1	affinity chromatography technology	Huttlin EL (2017)	1
FANCG	3	ERCC1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Wang C (2010), Wang C (2010), Wang C (2010)	3
SLX1B	0	PLK1	0	affinity chromatography technology	Svendsen JM (2009)	1
LYAR	0	ERCC4	2	biochemical	Wan C (2015)	1
ALYREF	0	ERCC4	2	biochemical	Havugimana PC (2012)	1
EGFR	5	5430	0	affinity chromatography technology	Yao Z (2017)	1
ERCC6	6	5430	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Anindya R (2010), Fousteri M (2006), Fousteri M (2006)	3
FANCG	3	ERCC4	2	two hybrid	Wang C (2010)	1
ERCC6	6	XPA	1	pull down, affinity chromatography technology	Selby CP (1997), Anindya R (2010)	2
SUMO2	0	MSH2	4	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
USP45	3	SLX4	6	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Perez-Oliva AB (2015)	2
NTRK1	1	MSH2	4	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	FANCD2	3	affinity chromatography technology	Emdal KB (2015)	1
ERCC1	1	ERCC4	2	pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	de Laat WL (1998), Park CH (1994), Ciccia A (2007), Havugimana PC (2012), Lan L (2004), Lan L (2004), Lan L (2004), Huttlin EL (2015), Wan C (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Liccardi G (2014), Huttlin EL (2017), Friboulet L (2013)	14
SPTA1	10	ERCC6	6	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
SUMO2	0	SLX4	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ouyang J (2009), Ouyang J (2015), Ouyang J (2015), Ouyang J (2015), Guervilly JH (2015), Guervilly JH (2015)	6
FANCA	5	SPTAN1	9	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McMahon LW (2001), McMahon LW (1999), Sridharan D (2003), McMahon LW (1999)	4
EGLN3	0	MSH2	4	affinity chromatography technology	Rodriguez J (2016)	1
SLX1B	0	MUS81	1	affinity chromatography technology	Svendsen JM (2009)	1
SLX1B	0	ERCC1	1	affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Huttlin EL (2017)	2
ZFC3H1	6	ERCC4	2	affinity chromatography technology	Huttlin EL (2017)	1
SUMO2	0	MUS81	1	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
EGLN3	0	ERCC4	2	affinity chromatography technology	Rodriguez J (2016)	1
SUMO2	0	SLX4IP	3	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
SPTA1	10	FANCG	3	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
ERCC4	2	SPTAN1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sridharan D (2003), McMahon LW (2001), McMahon LW (2001)	3
UBE2B	3	ERCC4	2	biochemical	Havugimana PC (2012)	1
ERCC1	1	SLX4IP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MUS81	1	ERCC4	2	affinity chromatography technology	Huttlin EL (2017)	1
GTF2H1	0	XPA	1	affinity chromatography technology	Araujo SJ (2001)	1
ERCC1	1	MSH2	4	affinity chromatography technology, affinity chromatography technology, biochemical	Lan L (2004), Lan L (2004), Lan L (2004)	3
SLX1A	0	SLX1B	0	affinity chromatography technology	Huttlin EL (2017)	1
SPTA1	10	ERCC1	1	affinity chromatography technology	Sridharan DM (2006)	1
GTF2H1	0	ERCC4	2	affinity chromatography technology	Araujo SJ (2001)	1
ERCC4	2	MSH2	4	affinity chromatography technology, affinity chromatography technology	Lan L (2004), Lan L (2004)	2
MSH2	4	XPA	1	pull down	Zhao J (2009)	1
FANCD2	3	MSH2	4	affinity chromatography technology, genetic interference	Williams SA (2011), Peng M (2014)	2
ERCC4	2	FANCA	5	affinity chromatography technology, affinity chromatography technology	Sridharan D (2003), Sridharan D (2003)	2
SPTA1	10	FANCD2	3	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
MUS81	1	FANCD2	3	genetic interference	Vizeacoumar FJ (2013)	1
PLK1	0	SLX4IP	3	affinity chromatography technology	Svendsen JM (2009)	1
SPTA1	10	XPA	1	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
GTF2H1	0	ERCC1	1	affinity chromatography technology	Araujo SJ (2001)	1