PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UHRF2	1	TP53	0	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Mori T (2011), Mori T (2011), Mori T (2011), Mori T (2011)	4
CDK7	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rossignol M (1997), Shiekhattar R (1995), Yee A (1995), Kershnar E (1998), Reardon JT (1996), Varjosalo M (2013)	6
NTRK1	1	HERC5	2	affinity chromatography technology	Emdal KB (2015)	1
GTF2H5	0	MNAT1	0	affinity chromatography technology	Hein MY (2015)	1
GTF2H3	2	GTF2H1	0	pull down, biochemical, affinity chromatography technology, pull down, biochemical, biochemical, affinity chromatography technology, pull down	Chymkowitch P (2011), Humbert S (1994), Humbert S (1994), Jawhari A (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	8
730394	0	CDK7	0	affinity chromatography technology	Huttlin EL (2017)	1
FAM96B	0	MMS19	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Stehling O (2012), Stehling O (2012), Lev I (2013), Stehling O (2013), Stehling O (2013), Gari K (2012), Gari K (2012), Huttlin EL (2015), Huttlin EL (2017)	10
ERCC3	3	CDK7	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Rossignol M (1997), Yee A (1995), Jeronimo C (2007), Jeronimo C (2007), Reardon JT (1996), Chen D (1999), Varjosalo M (2013), Huttlin EL (2017), Luo J (2015)	10
NTRK1	1	EIF2A	0	affinity chromatography technology	Emdal KB (2015)	1
UVSSA	5	GTF2H1	0	affinity chromatography technology	Fei J (2012)	1
CDK7	0	CCNH	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Maekelae TP (1994), Maekelae TP (1994), Maekelae TP (1994), Maekelae TP (1994), Yee A (1995), Garber ME (2000), Garber ME (2000), Jeronimo C (2007), Reardon JT (1996), Liu J (1997), Cujec TP (1997), Epie N (2005), Bockstaele L (2006), Tassan JP (1995), Chen D (1999), Havugimana PC (2012), Poterszman A (1997), Nguyen VT (2001), Garrett S (2001), Pinhero R (2004), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Luo J (2015)	25
AR	3	GTF2H1	0	affinity chromatography technology	Lee DK (2000)	1
MNAT1	0	GTF2H3	2	biochemical	Havugimana PC (2012)	1
ERCC3	3	CCNH	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Jeronimo C (2007), Drapkin R (1996), Drapkin R (1996), Huttlin EL (2015), Huttlin EL (2017), Luo J (2015)	7
SPTA1	10	ERCC3	3	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
TP53	0	ERCC6	6	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wang XW (1995), Yu A (2000), Yu A (2000), Latini P (2011), Latini P (2011)	5
UVSSA	5	ERCC2	4	affinity chromatography technology	Fei J (2012)	1
GTF2H5	0	CDK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Varjosalo M (2013), Hein MY (2015)	3
ACAT1	1	TOPBP1	5	biochemical	Havugimana PC (2012)	1
ERCC3	3	GTF2H3	2	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Marinoni JC (1997), Jeronimo C (2007), Humbert S (1994), Humbert S (1994), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	9
NTRK1	1	GTF2F1	0	affinity chromatography technology	Emdal KB (2015)	1
ERCC3	3	MMS19	5	affinity chromatography technology	Seroz T (2000)	1
XPO1	8	WDR61	0	affinity chromatography technology	Kirli K (2015)	1
GTF2H1	0	MNAT1	0	biochemical, biochemical, pull down	Kershnar E (1998), Havugimana PC (2012), Luo J (2015)	3
SPTA1	10	ERCC5	0	affinity chromatography technology	Sridharan DM (2006)	1
MMS19	5	GTF2H1	0	affinity chromatography technology	Seroz T (2000)	1
MMS19	5	XPO1	8	affinity chromatography technology	Stehling O (2012)	1
NTRK1	1	XPO1	8	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	GTF2F1	0	affinity chromatography technology	Choudhury NR (2017)	1
RAD52	5	ERCC2	4	affinity chromatography technology, affinity chromatography technology	Liu J (2002), Liu J (2002)	2
CIAO1	3	WDR61	0	affinity chromatography technology	Stehling O (2013)	1
ACAT1	1	ERCC2	4	biochemical	Wan C (2015)	1
GTF2H3	2	AR	3	affinity chromatography technology, pull down	Chymkowitch P (2011), Chymkowitch P (2011)	2
TP53	0	GTF2H1	0	pull down, pull down, pull down, pull down, far western blotting, pull down, x-ray crystallography	Xiao H (1994), Di Lello P (2008), Okuda M (2008), Leveillard T (1996), Leveillard T (1996), Di Lello P (2006), Di Lello P (2006)	7
CCNH	3	MNAT1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Talukder AH (2003), Bockstaele L (2006), Havugimana PC (2012), Pinhero R (2004), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
GTF2H5	0	GTF2H1	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
TRIM25	5	ERCC2	4	pull down	Takeuchi T (2006)	1
WDR61	0	ERCC2	4	biochemical	Wan C (2015)	1
ERCC5	0	ERCC2	4	affinity chromatography technology, pull down	Iyer N (1996), Iyer N (1996)	2
ERCC2	4	CTPS1	2	biochemical	Wan C (2015)	1
GTF2H1	0	CCNH	3	biochemical, biochemical, affinity chromatography technology	Shiekhattar R (1995), Kershnar E (1998), Araujo SJ (2001)	3
GTF2H3	2	730394	0	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
UVSSA	5	ERCC3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fei J (2012), Fei J (2012), Fei J (2012)	3
MNAT1	0	GTF2H2	0	affinity chromatography technology, pull down	Drapkin R (1996), Luo J (2015)	2
AR	3	CCNH	3	pull down	Lee DK (2000)	1
CDK7	0	MNAT1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Talukder AH (2003), Yee A (1995), Jeronimo C (2007), Busso D (2000), Cujec TP (1997), Tassan JP (1995), Chen D (1999), Havugimana PC (2012), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Luo J (2015)	13
CDK7	0	GTF2H3	2	affinity chromatography technology, pull down, affinity chromatography technology	Jeronimo C (2007), Chymkowitch P (2011), Varjosalo M (2013)	3
ERCC3	3	ERCC2	4	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Drapkin R (1994), Iyer N (1996), Iyer N (1996), Havugimana PC (2012), Stehling O (2012), Luo J (2015), Luo J (2015)	9
NTRK1	1	MMS19	5	affinity chromatography technology	Emdal KB (2015)	1
ATF7IP	5	ERCC3	3	affinity chromatography technology	Liu L (2009)	1
ERCC2	4	GTF2H1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Drapkin R (1994), Rossignol M (1997), Seroz T (2000), Luo J (2015), Luo J (2015)	5
GTF2H5	0	ERCC2	4	affinity chromatography technology	Hein MY (2015)	1
ERCC2	4	MNAT1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Busso D (2000), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017), Luo J (2015)	5
TP53	0	ERCC3	3	pull down, affinity chromatography technology, pull down, pull down, pull down	Wang XW (1995), Wang XW (1995), Qadri I (2002), Qadri I (2002), Leveillard T (1996)	5
EIF2A	0	ERCC2	4	biochemical	Wan C (2015)	1
730394	0	ERCC3	3	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
ERCC3	3	GTF2H1	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Marinoni JC (1997), Rossignol M (1997), Jeronimo C (2007), Drapkin R (1996), Araujo SJ (2001), Havugimana PC (2012), Maru Y (1999), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	12
GTF2H3	2	GTF2H2	0	pull down, affinity chromatography technology, pull down, biochemical, biochemical, affinity chromatography technology, pull down	Chymkowitch P (2011), Kellenberger E (2005), Jawhari A (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Luo J (2015)	7
EGFR	5	ERCC2	4	affinity chromatography technology	Liccardi G (2014)	1
CLUH	8	ERCC2	4	biochemical	Wan C (2015)	1
CDK7	0	ERCC2	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reardon JT (1996), Havugimana PC (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
GTF2H2	0	GTF2H5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Vermeulen W (2000), Giglia-Mari G (2006), Hein MY (2015), Huttlin EL (2017)	5
CIAO1	3	ERCC2	4	affinity chromatography technology, affinity chromatography technology	Stehling O (2013), Stehling O (2013)	2
ISG15	0	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Zou W (2007), Zou W (2007)	2
AR	3	ERCC3	3	affinity chromatography technology, pull down	Chymkowitch P (2011), Chymkowitch P (2011)	2
ERCC3	3	ERCC5	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017)	2
AR	3	GTF2F1	0	pull down	McEwan IJ (1997)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
ISG15	0	ERCC2	4	affinity chromatography technology	Takeuchi T (2006)	1
ERCC2	4	MMS19	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Seroz T (2000), Stehling O (2012), Stehling O (2012), Stehling O (2012), Gari K (2012), Gari K (2012)	6
AR	3	CDK7	0	affinity chromatography technology, pull down, pull down, enzymatic study	Lee DK (2000), Lee DK (2000), Chymkowitch P (2011), Chymkowitch P (2011)	4
MMS19	5	GTF2F1	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
ERCC3	3	GTF2H2	0	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Jeronimo C (2007), Humbert S (1994), Humbert S (1994), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	9
FAM96B	0	ERCC2	4	affinity chromatography technology, affinity chromatography technology	Stehling O (2013), Stehling O (2013)	2
HERC5	2	ERCC2	4	pull down	Takeuchi T (2006)	1
GTF2H5	0	ERCC3	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Giglia-Mari G (2004), Giglia-Mari G (2006), Hein MY (2015), Huttlin EL (2017), Luo J (2015)	6
TRIM25	5	GTF2H1	0	affinity chromatography technology	Choudhury NR (2017)	1
GTF2H1	0	ERCC5	0	affinity chromatography technology, pull down	Araujo SJ (2001), Gervais V (2004)	2
AR	3	GTF2H2	0	pull down	Chymkowitch P (2011)	1
TP53	0	CCNH	3	far western blotting, affinity chromatography technology	Schneider E (1998), Schneider E (1998)	2
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
GTF2H5	0	CCNH	3	affinity chromatography technology	Hein MY (2015)	1
CDK7	0	TP53	0	enzymatic study, affinity chromatography technology, enzymatic study, pull down	Ko LJ (1997), Schneider E (1998), Lu H (1997), Lu H (1997)	4
GTF2H5	0	ERCC5	0	affinity chromatography technology	Hein MY (2015)	1
UVSSA	5	CDK7	0	affinity chromatography technology	Fei J (2012)	1
TP53	0	ERCC2	4	pull down, far western blotting, pull down	Wang XW (1995), Leveillard T (1996), Leveillard T (1996)	3
NTRK1	1	CLUH	8	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	CTPS1	2	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	MMS19	5	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
TOPBP1	5	ERCC2	4	biochemical	Wan C (2015)	1
TP53	0	MNAT1	0	pull down, affinity chromatography technology	Ko LJ (1997), Ko LJ (1997)	2
ATF7IP	5	ERCC2	4	affinity chromatography technology	Liu L (2009)	1
GTF2H2	0	CDK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen W (2000), Jeronimo C (2007), Varjosalo M (2013)	3
CDK7	0	ERCC5	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Varjosalo M (2013)	2
SPTA1	10	ERCC2	4	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
GTF2F1	0	ERCC2	4	affinity chromatography technology	Cujec TP (1997)	1
SPTA1	10	ERCC6	6	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
AR	3	ERCC2	4	pull down	Chymkowitch P (2011)	1
XPO1	8	730394	0	affinity chromatography technology	Kirli K (2015)	1
RAD52	5	ERCC3	3	affinity chromatography technology, affinity chromatography technology	Liu J (2002), Liu J (2002)	2
PIDD1	5	ERCC5	0	affinity chromatography technology	Logette E (2011)	1
XPO1	8	ERCC2	4	affinity chromatography technology	Kirli K (2015)	1
ERCC2	4	GTF2H2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Coin F (1998), Coin F (1998), Vermeulen W (2000), Dubaele S (2003), Luo J (2015)	5
ERCC3	3	MNAT1	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Jeronimo C (2007), Drapkin R (1996), Drapkin R (1996), Huttlin EL (2017), Luo J (2015), Luo J (2015)	7
GTF2H5	0	GTF2H3	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CCNH	3	ERCC2	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Drapkin R (1996), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	4
TRIM25	5	ERCC3	3	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	ACAT1	1	affinity chromatography technology	Emdal KB (2015)	1
PIDD1	5	ERCC2	4	affinity chromatography technology	Logette E (2011)	1
CCNH	3	ERCC5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERCC6	6	ERCC2	4	affinity chromatography technology	Anindya R (2010)	1
ERCC6	6	ERCC5	0	affinity chromatography technology, far western blotting	Fousteri M (2006), Sarker AH (2005)	2
EGFR	5	AR	3	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004)	4
HERC5	2	TP53	0	affinity chromatography technology	Huang YF (2014)	1
NTRK1	1	ERCC2	4	affinity chromatography technology	Emdal KB (2015)	1
ERCC2	4	730394	0	two hybrid	Rolland T (2014)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
NTRK1	1	CTPS1	2	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	GTF2F1	0	affinity chromatography technology	Kirli K (2015)	1
ERCC6	6	ERCC3	3	affinity chromatography technology	Fousteri M (2006)	1
GTF2F1	0	GTF2H1	0	affinity chromatography technology	Cujec TP (1997)	1
ISG15	0	HERC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao C (2005), Wong JJ (2006), Woods MW (2014)	3
CIAO1	3	MMS19	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology	Havugimana PC (2012), Stehling O (2012), Stehling O (2012), Lev I (2013), Stehling O (2013), Stehling O (2013), Rolland T (2014), Gari K (2012), Gari K (2012), Gari K (2012), Huttlin EL (2015), Wan C (2015), Yu H (2011), Huttlin EL (2017)	14
GTF2H2	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, pull down	Vermeulen W (2000), Humbert S (1994), Humbert S (1994), Wang J (2011), Wan C (2015), Luo J (2015)	6
730394	0	GTF2H5	0	affinity chromatography technology	Huttlin EL (2017)	1
730394	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
UHRF2	1	ERCC2	4	affinity chromatography technology	Lai M (2016)	1
CIAO1	3	FAM96B	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid	Rual JF (2005), Havugimana PC (2012), Stehling O (2013), Stehling O (2013), Stehling O (2013), Stehling O (2013), Rolland T (2014), Gari K (2012), Wan C (2015), Yu H (2011)	10
GTF2H2	0	CCNH	3	affinity chromatography technology	Vermeulen W (2000)	1
GTF2H3	2	ERCC2	4	pull down	Chymkowitch P (2011)	1