PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
5430	0	ERCC4	2	affinity chromatography technology	Fousteri M (2006)	1
ERCC1	1	MUS81	1	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Huttlin EL (2017)	2
TAF6	4	TAF12	0	two hybrid	Bando M (1997)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
ERCC1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Liccardi G (2014), Liccardi G (2014), Liccardi G (2014), Liccardi G (2014)	4
ERCC1	1	TOPBP1	5	biochemical	Wan C (2015)	1
XPA	1	RPA1	0	two hybrid, pull down, affinity chromatography technology	Li L (1995), Li L (1995), Lange SS (2009)	3
ERCC1	1	TAF7	0	affinity chromatography technology	Kamileri I (2012)	1
SLX4	6	APP	1	pull down	Olah J (2011)	1
SPTA1	10	ERCC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sridharan D (2003), Sridharan DM (2006), Sridharan DM (2006)	3
UHRF1	3	MSH2	4	affinity chromatography technology	Ferry L (2017)	1
TAF6	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
SLX4	6	SLX1B	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Svendsen JM (2009), Svendsen JM (2009), Wan B (2013), Wan B (2013), Wan B (2013)	5
SLX1B	0	ERCC4	2	affinity chromatography technology	Svendsen JM (2009)	1
SLX4	6	ERCC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, biochemical, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Andersen SL (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Kim Y (2013), Wilson JS (2013), Wilson JS (2013), Wan B (2013), Wan B (2013), Wan B (2013), Perez-Oliva AB (2015), Schuster B (2013), Bogliolo M (2013)	20
TAF10	0	5430	0	affinity chromatography technology	Kouskouti A (2004)	1
ERCC1	1	TWF2	2	biochemical	Wan C (2015)	1
SLX4IP	3	ERCC4	2	affinity chromatography technology	Svendsen JM (2009)	1
GTF2H1	0	RPA1	0	affinity chromatography technology	Araujo SJ (2001)	1
TAF10	0	TAF6	4	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical	Kouskouti A (2004), Demeny MA (2007), Cavusoglu N (2003), Havugimana PC (2012), Wan C (2015)	5
ERCC1	1	MKRN3	2	two hybrid	Rolland T (2014)	1
ACAT1	1	TOPBP1	5	biochemical	Havugimana PC (2012)	1
5430	0	ERCC1	1	affinity chromatography technology	Fousteri M (2006)	1
TBP	0	TAF12	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Knuesel MT (2009), Liu X (2008), Denissov S (2007), Wieczorek E (1998), Hoffmann A (1996), Hoffmann A (1996)	6
RPA2	0	EGFR	5	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	MSH2	4	affinity chromatography technology, biochemical	Marechal A (2014), Wan C (2015)	2
UHRF1	3	MUS81	1	affinity chromatography technology, affinity chromatography technology, pull down	Tian Y (2015), Tian Y (2015), Tian Y (2015)	3
GTF2H1	0	USHBP1	1	two hybrid	Wang J (2011)	1
ERCC1	1	UBL7	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RPA1	0	EGFR	5	affinity chromatography technology	Marechal A (2014)	1
GTF2H1	0	RPA2	0	affinity chromatography technology	Araujo SJ (2001)	1
ERCC1	1	TBP	0	affinity chromatography technology	Kamileri I (2012)	1
SLX1A	0	ERCC4	2	pull down, pull down	Munoz IM (2009), Fekairi S (2009)	2
UHRF1	3	ERCC4	2	affinity chromatography technology	Tian Y (2015)	1
ERCC1	1	TRMT2B	1	two hybrid	Rolland T (2014)	1
SLX1B	0	SLX4IP	3	affinity chromatography technology	Svendsen JM (2009)	1
ERCC1	1	TAF6	4	affinity chromatography technology, affinity chromatography technology	Kamileri I (2012), Kamileri I (2012)	2
SLX4	6	SLX4IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012)	5
RPA2	0	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
5430	0	RPA1	0	affinity chromatography technology	Fousteri M (2006)	1
USP45	3	ERCC1	1	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, enzymatic study, affinity chromatography technology	Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015)	6
EGFR	5	ERCC4	2	affinity chromatography technology	Liccardi G (2014)	1
SLX4	6	MSH2	4	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012)	4
APP	1	ERCC1	1	pull down	Virok DP (2011)	1
SLX4	6	TOPBP1	5	affinity chromatography technology	Gritenaite D (2014)	1
TOPBP1	5	RPA1	0	imaging technique	Gong Z (2010)	1
SPTA1	10	RPA1	0	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
ERCC1	1	VPS37B	2	two hybrid	Rolland T (2014)	1
TAF6	4	TAF7	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Gupta K (2017)	2
ERCC1	1	RPA2	0	fluorescent resonance energy transfe	Friboulet L (2013)	1
SLX4	6	ERCC1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Munoz IM (2009), Munoz IM (2009), Kim Y (2013), Huttlin EL (2015), Perez-Oliva AB (2015), Huttlin EL (2017), Schuster B (2013), Bogliolo M (2013)	12
SLX1A	0	ERCC1	1	pull down	Munoz IM (2009)	1
5430	0	XPA	1	affinity chromatography technology	Fousteri M (2006)	1
MAGIX	0	ERCC1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPA	1	ERCC4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UHRF1	3	ERCC1	1	affinity chromatography technology, affinity chromatography technology, pull down	Tian Y (2015), Tian Y (2015), Tian Y (2015)	3
GTF2H1	0	5430	0	enzymatic study, biochemical, enzymatic study	Moisan A (2004), Yankulov K (1999), Parada CA (1996)	3
FANCG	3	USHBP1	1	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
RPA2	0	MSH2	4	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	CDC5L	2	affinity chromatography technology, pull down, affinity chromatography technology	Marechal A (2014), Marechal A (2014), Lleres D (2010)	3
SLX1A	0	MUS81	1	pull down, pull down	Munoz IM (2009), Fekairi S (2009)	2
XPA	1	ERCC1	1	two hybrid, pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Li L (1994), Li L (1994), Li L (1994), Nagai A (1995), Nagai A (1995), Wakasugi M (2009), Huttlin EL (2015), Huttlin EL (2017), Friboulet L (2013)	9
SLX4	6	MUS81	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Kim Y (2013), Wilson JS (2013), Wan B (2013), Wan B (2013), Wan B (2013), Rolland T (2014), Yu H (2011), Nair N (2014), Nair N (2014), Nair N (2014), Ouyang J (2015), Huttlin EL (2017), Schuster B (2013), Bogliolo M (2013)	21
XPA	1	RPA2	0	pull down, affinity chromatography technology	Mer G (2000), Fan W (2010)	2
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
USP45	3	ERCC4	2	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Perez-Oliva AB (2015)	2
SLX4	6	SLX1A	0	two hybrid, pull down, pull down, biochemical, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Fekairi S (2009), Fekairi S (2009), Kim Y (2013), Wan B (2013), Wan B (2013), Wan B (2013)	11
ZFC3H1	6	ERCC1	1	affinity chromatography technology	Huttlin EL (2017)	1
FANCG	3	ERCC1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Wang C (2010), Wang C (2010), Wang C (2010)	3
TAF7	0	TAF12	0	affinity chromatography technology	Gupta K (2017)	1
TBP	0	TAF6	4	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Ruppert S (1993), Knuesel MT (2009), Nakamura T (2002), Liu X (2008), Demeny MA (2007), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Kamileri I (2012), Havugimana PC (2012), Soutoglou E (2005), Ogryzko VV (1998)	14
RPA3	2	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
EGFR	5	5430	0	affinity chromatography technology	Yao Z (2017)	1
ERCC1	1	USHBP1	1	two hybrid	Rolland T (2014)	1
TBP	0	TAF10	0	biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Bellorini M (1997), Ruppert S (1993), Knuesel MT (2009), Kouskouti A (2004), Liu X (2008), Demeny MA (2007), Wieczorek E (1998), Wieczorek E (1998), Kamileri I (2012), Havugimana PC (2012), Le Douarin B (1995)	11
FANCG	3	ERCC4	2	two hybrid	Wang C (2010)	1
USP45	3	SLX4	6	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Perez-Oliva AB (2015)	2
ERCC1	1	RPA3	2	fluorescent resonance energy transfe	Friboulet L (2013)	1
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
CDC5L	2	MSH2	4	affinity chromatography technology	Lleres D (2010)	1
TWF2	2	UBL7	0	biochemical	Havugimana PC (2012)	1
5430	0	TBP	0	biochemical, pull down, affinity chromatography technology, pull down	Scully R (1997), Scully R (1997), McCracken S (1997), Dantonel JC (1997)	4
ERCC1	1	C15orf40	2	biochemical	Wan C (2015)	1
ERCC1	1	ACAT1	1	biochemical	Wan C (2015)	1
ERCC1	1	ERCC4	2	pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	de Laat WL (1998), Park CH (1994), Ciccia A (2007), Havugimana PC (2012), Lan L (2004), Lan L (2004), Lan L (2004), Huttlin EL (2015), Wan C (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Liccardi G (2014), Huttlin EL (2017), Friboulet L (2013)	14
RPA3	2	MSH2	4	affinity chromatography technology	Marechal A (2014)	1
TAF10	0	TAF7	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Jeronimo C (2007), Kouskouti A (2004), Wieczorek E (1998), Havugimana PC (2012), Gupta K (2017)	5
SLX1B	0	MUS81	1	affinity chromatography technology	Svendsen JM (2009)	1
ERCC1	1	RPA1	0	fluorescent resonance energy transfe	Friboulet L (2013)	1
TBP	0	TAF7	0	affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Knuesel MT (2009), Wieczorek E (1998), Dantonel JC (1997), Dantonel JC (1997), Kamileri I (2012), Gupta K (2017)	8
SLX1B	0	ERCC1	1	affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Huttlin EL (2017)	2
ZFC3H1	6	APP	1	pull down, affinity chromatography technology	Olah J (2011), Hein MY (2015)	2
ZFC3H1	6	ERCC4	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC5L	2	ERCC1	1	affinity chromatography technology	Lleres D (2010)	1
FANCG	3	RPA1	0	affinity chromatography technology	Meetei AR (2003)	1
SPTA1	10	FANCG	3	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
ERCC1	1	TAF12	0	affinity chromatography technology, affinity chromatography technology	Kamileri I (2012), Kamileri I (2012)	2
RPA2	0	APP	1	pull down	Olah J (2011)	1
ERCC1	1	TAF10	0	affinity chromatography technology, affinity chromatography technology	Kamileri I (2012), Kamileri I (2012)	2
ERCC1	1	SLX4IP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MUS81	1	ERCC4	2	affinity chromatography technology	Huttlin EL (2017)	1
TAF10	0	TAF12	0	affinity chromatography technology	Cavusoglu N (2003)	1
RPA3	2	EGFR	5	affinity chromatography technology	Marechal A (2014)	1
GTF2H1	0	XPA	1	affinity chromatography technology	Araujo SJ (2001)	1
ERCC1	1	MSH2	4	affinity chromatography technology, affinity chromatography technology, biochemical	Lan L (2004), Lan L (2004), Lan L (2004)	3
SLX1A	0	SLX1B	0	affinity chromatography technology	Huttlin EL (2017)	1
SPTA1	10	ERCC1	1	affinity chromatography technology	Sridharan DM (2006)	1
GTF2H1	0	ERCC4	2	affinity chromatography technology	Araujo SJ (2001)	1
ERCC4	2	MSH2	4	affinity chromatography technology, affinity chromatography technology	Lan L (2004), Lan L (2004)	2
MSH2	4	XPA	1	pull down	Zhao J (2009)	1
SPTA1	10	RPA2	0	affinity chromatography technology	Sridharan DM (2006)	1
SLX4	6	RPA1	0	affinity chromatography technology	Ouyang J (2015)	1
SPTA1	10	XPA	1	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
GTF2H1	0	ERCC1	1	affinity chromatography technology	Araujo SJ (2001)	1