PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CLN8	0	TMEM147	1	two hybrid	Passantino R (2013)	1
CLN8	0	UBC	7	two hybrid	Passantino R (2013)	1
BNIP3	2	BNIP3L	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	6
RTN4	4	ARL6IP5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAPA	1	RTN4	4	biochemical	Wan C (2015)	1
CLN8	0	SELENOK	0	two hybrid	Passantino R (2013)	1
CLN8	0	CYB5B	1	two hybrid	Passantino R (2013)	1
CLN8	0	TMEM11	2	two hybrid	Passantino R (2013)	1
CLN8	0	PDIA6	1	two hybrid	Passantino R (2013)	1
TMEM128	0	ARL6IP5	0	affinity chromatography technology	Huttlin EL (2017)	1
BNIP3	2	TMEM11	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Rolland T (2014), Huttlin EL (2017)	4
GABARAPL2	0	BNIP3L	1	affinity chromatography technology	Novak I (2010)	1
CLN8	0	TMEM107	0	two hybrid	Passantino R (2013)	1
CLN8	0	ERG28	0	two hybrid	Passantino R (2013)	1
CLN8	0	PLP1	0	two hybrid	Passantino R (2013)	1
CLN8	0	TMEM134	0	two hybrid	Passantino R (2013)	1
CLN8	0	BNIP3	2	two hybrid	Passantino R (2013)	1
PLP1	0	PTPRN	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CLN8	0	RRP15	1	two hybrid	Passantino R (2013)	1
CLN8	0	NDRG2	1	two hybrid	Passantino R (2013)	1
CLN8	0	PTPRN	3	two hybrid	Passantino R (2013)	1
CLN8	0	BNIP3L	1	two hybrid	Passantino R (2013)	1
CLN8	0	STX8	0	two hybrid	Passantino R (2013)	1
CLN8	0	RTN4	4	two hybrid	Passantino R (2013)	1
CLN8	0	ARL6IP5	0	two hybrid	Passantino R (2013)	1
CLN8	0	TMEM128	0	two hybrid	Passantino R (2013)	1
CLN8	0	CD9	1	two hybrid	Passantino R (2013)	1
CLN8	0	GABARAPL2	0	two hybrid	Passantino R (2013)	1
CLN8	0	TUBB4A	3	two hybrid	Passantino R (2013)	1
ZUFSP	0	UBC	7	enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Hermanns T (2018), Hermanns T (2018), Hermanns T (2018), Kwasna D (2018), Kwasna D (2018), Kwasna D (2018), Haahr P (2018), Haahr P (2018), Haahr P (2018)	9
CLN8	0	VAPA	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Passantino R (2013), Passantino R (2013), Passantino R (2013)	3
CLN8	0	ZUFSP	0	two hybrid	Passantino R (2013)	1
CLN8	0	SPCS2	2	two hybrid	Passantino R (2013)	1
CLN8	0	TMEM14A	1	two hybrid	Passantino R (2013)	1
GABARAPL2	0	VAPA	1	affinity chromatography technology	Passantino R (2013)	1
CLN8	0	GPM6B	0	two hybrid	Passantino R (2013)	1
CLN8	0	YIPF6	0	two hybrid	Passantino R (2013)	1
CLN8	0	PLP2	0	two hybrid	Passantino R (2013)	1
CLN8	0	MTX1	0	two hybrid	Passantino R (2013)	1
BNIP3L	1	TMEM11	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TMEM128	0	RTN4	4	affinity chromatography technology	Huttlin EL (2017)	1
PTPRN	3	PDIA6	1	bioid, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2