PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	CCT2	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
TUBA1A	13	TUBB	3	biochemical, biochemical, pull down	Havugimana PC (2012), Kristensen AR (2012), Wang W (2014)	3
BRCA1	7	TUBB	3	affinity chromatography technology, affinity chromatography technology	Lotti LV (2002), Ertych N (2016)	2
LRRK2	5	AKT1	1	enzymatic study, pull down	Ohta E (2011), Ohta E (2011)	2
CBL	7	TUBB	3	affinity chromatography technology, affinity chromatography technology	Teckchandani AM (2005), Brehme M (2009)	2
CDK13	18	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TUBA1C	1	CCT2	1	affinity chromatography technology	Hein MY (2015)	1
AP2M1	5	TUBB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
BRCA1	7	CCT2	1	affinity chromatography technology	Ertych N (2016)	1
TUBA1C	1	EEF1A1	0	affinity chromatography technology	Hein MY (2015)	1
TUBA4A	1	EEF1A1	0	biochemical	Wan C (2015)	1
BRCA1	7	TUBA4A	1	affinity chromatography technology	Ertych N (2016)	1
CDK13	18	TUBA1C	1	affinity chromatography technology	Huttlin EL (2015)	1
PEX14	2	TUBB4B	6	biochemical	Bharti P (2011)	1
HDAC6	0	TUBB4B	6	affinity chromatography technology, affinity chromatography technology	New M (2013), Watson GW (2016)	2
TUBA1A	13	MAPRE1	0	pull down	Ligon LA (2006)	1
BUB1B	0	TUBB	3	biochemical, genetic interference	Izumi H (2009), Horlbeck MA (2018)	2
TP53	0	TUBB2A	2	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
VCP	6	TUBB4B	6	affinity chromatography technology, biochemical	Fogeron ML (2013), Wan C (2015)	2
TUBA1C	1	TUBB4B	6	biochemical, affinity chromatography technology	Kristensen AR (2012), Hein MY (2015)	2
HDAC6	0	XPO1	8	affinity chromatography technology, affinity chromatography technology	Riolo MT (2012), Kirli K (2015)	2
TUBB2A	2	TUBB	3	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2017)	3
AP2M1	5	TUBB2A	2	affinity chromatography technology	Brehme M (2009)	1
SYT9	3	TUBB	3	pull down, affinity chromatography technology	Haberman Y (2003), Haberman Y (2003)	2
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
TUBA4A	1	TUBB	3	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
PEX14	2	TUBA4A	1	biochemical	Bharti P (2011)	1
EEF1A1	0	LRRK2	5	affinity chromatography technology	Gillardon F (2009)	1
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
TUBB	3	CCT2	1	pull down, affinity chromatography technology	Lin YF (2012), Huttlin EL (2017)	2
729873	0	TUBB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	He Z (2014), He Z (2014), He Z (2014)	3
HDAC6	0	TUBB2A	2	enzymatic study, enzymatic study	Hubbert C (2002), Gibbs A (2009)	2
TUBB4B	6	XPO1	8	biochemical, affinity chromatography technology	Havugimana PC (2012), Kirli K (2015)	2
PEX14	2	TUBB	3	biochemical, biochemical, affinity chromatography technology	Bharti P (2011), Bharti P (2011), Huttlin EL (2017)	3
TUBB2A	2	TUBA1C	1	biochemical	Kristensen AR (2012)	1
AP2M1	5	EEF1A1	0	affinity chromatography technology	Brehme M (2009)	1
BRCA1	7	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology	Zhang H (2000), Zhang H (2000), Ertych N (2016)	3
CBL	7	TUBB4B	6	affinity chromatography technology	Brehme M (2009)	1
HTRA2	1	EEF1A1	0	unspecified method, enzymatic study	Vande Walle L (2007), Vande Walle L (2007)	2
TUBA1C	1	TUBB	3	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3
HTT	14	TUBB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mitsui K (2002), Hoffner G (2002), Hoffner G (2002)	3
HTT	14	TP53	0	pull down, affinity chromatography technology	Steffan JS (2000), Steffan JS (2000)	2
TP53	0	TUBA4A	1	affinity chromatography technology	Fogeron ML (2013)	1
VCP	6	TUBB	3	affinity chromatography technology, biochemical	Fogeron ML (2013), Wan C (2015)	2
PEX14	2	TUBB2A	2	biochemical	Bharti P (2011)	1
TUBA1C	1	TUBA4A	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2017)	3
HTT	14	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang H (2010), Yu CC (2013), Fujita K (2013), Fujita K (2013)	4
HTRA2	1	VCP	6	affinity chromatography technology	Raman M (2015)	1
VAV1	2	TUBA1A	13	affinity chromatography technology, affinity chromatography technology, pull down	Huby RD (1995), Huby RD (1995), Huby RD (1995)	3
TP53	0	TUBA1C	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
TP53	0	EEF1A1	0	affinity chromatography technology	Fogeron ML (2013)	1
TUBB2A	2	TUBB4B	6	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
TUBB4B	6	TUBB	3	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
TUBA1A	13	CBL	7	affinity chromatography technology	Teckchandani AM (2005)	1
CBL	7	VAV1	2	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Bertagnolo V (2001), Miura-Shimura Y (2003), Simmons A (2005), Shen M (2009), Shen M (2009), Lottin-Divoux S (2006), Lottin-Divoux S (2006), Peterson ME (2008)	12
TP53	0	TUBB4B	6	affinity chromatography technology	Fogeron ML (2013)	1
LRRK2	5	TUBB	3	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gandhi PN (2008), Gandhi PN (2008), Gandhi PN (2008), Gillardon F (2009)	4
LRRK2	5	TUBA1A	13	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee S (2010), Kawakami F (2012), Kawakami F (2012)	3
MAPRE1	0	TUBB	3	pull down, pull down	Kanaba T (2012), Ligon LA (2006)	2
TP53	0	TUBB	3	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
TUBA1A	13	TUBB2A	2	biochemical	Havugimana PC (2012)	1
HDAC6	0	TUBB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao Z (2010), Zhao Z (2010), New M (2013), Watson GW (2016)	4
AKT1	1	TUBB	3	affinity chromatography technology, affinity chromatography technology	Klein JB (2005), Zhu QS (2011)	2
CBL	7	TUBA1C	1	affinity chromatography technology	Brehme M (2009)	1
TUBB	3	XPO1	8	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
HDAC6	0	EEF1A1	0	affinity chromatography technology	Watson GW (2016)	1
AP2M1	5	TUBA1A	13	affinity chromatography technology	Brehme M (2009)	1
XPO1	8	TUBA4A	1	affinity chromatography technology	Kirli K (2015)	1
CDK13	18	TUBB	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GDAP1	0	TUBB	3	two hybrid, affinity chromatography technology	Estela A (2011), Estela A (2011)	2
XPO1	8	CBL	7	affinity chromatography technology	Kirli K (2015)	1
TUBA1A	13	TUBB4B	6	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
TUBA1A	13	729873	0	affinity chromatography technology	He Z (2014)	1
AP2M1	5	TUBA1C	1	affinity chromatography technology	Brehme M (2009)	1
PEX14	2	TUBA1A	13	biochemical	Bharti P (2011)	1
VAV1	2	TUBB	3	affinity chromatography technology, affinity chromatography technology	Huby RD (1995), Fernandez JA (1999)	2
CDK13	18	TUBA4A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TUBB	3	ZNHIT6	2	affinity chromatography technology, genetic interference	Huttlin EL (2017), Horlbeck MA (2018)	2
HTT	14	TUBA1A	13	affinity chromatography technology	Mitsui K (2002)	1
CBL	7	EEF1A1	0	affinity chromatography technology	Feshchenko EA (2004)	1
TUBB	3	MAGEA2B	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TUBA1A	13	TUBA4A	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2017)	3
TP53	0	TUBA1A	13	affinity chromatography technology	Fogeron ML (2013)	1
AKT1	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Vandermoere F (2006), Vandermoere F (2006), Vandermoere F (2006), Klein JB (2005), Klein JB (2005), Klein JB (2005), Yu CC (2013), Yu CC (2013)	8
TUBA4A	1	TUBB4B	6	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
CCT2	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology	Lin YF (2012), Lin YF (2012), Yu CC (2013)	3
LRRK2	5	TUBA1C	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Gandhi PN (2008), Gandhi PN (2008), Gandhi PN (2008)	3
LRRK2	5	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Ho DH (2015), Ho DH (2015), Ho DH (2015)	3
EEF1A1	0	TUBB	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
XPO1	8	AP2M1	5	affinity chromatography technology	Kirli K (2015)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BRCA1	7	TUBB4B	6	affinity chromatography technology	Ertych N (2016)	1
HTRA2	1	TUBA1A	13	unspecified method, enzymatic study	Vande Walle L (2007), Vande Walle L (2007)	2
HTRA2	1	TUBB	3	unspecified method, enzymatic study	Vande Walle L (2007), Vande Walle L (2007)	2
XPO1	8	BUB1B	0	affinity chromatography technology	Kirli K (2015)	1
HDAC6	0	TUBA1A	13	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Matsuyama A (2002), Hubbert C (2002), Zhao Z (2010), Zhao Z (2010), New M (2013)	6
HDAC6	0	MAPRE1	0	affinity chromatography technology	Zilberman Y (2009)	1
PEX14	2	CCT2	1	biochemical	Bharti P (2011)	1
AP2M1	5	PEX14	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	AKT1	1	pull down, affinity chromatography technology, pull down, enzymatic study, pull down	Altiok S (1999), Xiang T (2008), Xiang T (2008), Xiang T (2008), Xiang T (2011)	5
TUBB2A	2	CCT2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	TUBA1C	1	affinity chromatography technology	Fogeron ML (2013)	1
AP2M1	5	TUBB4B	6	affinity chromatography technology	Brehme M (2009)	1
HDAC6	0	TUBA1C	1	affinity chromatography technology	New M (2013)	1
TUBA4A	1	TUBB2A	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
BUB1B	0	CCT2	1	affinity chromatography technology	So J (2015)	1
CDK13	18	TUBB4B	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	TUBA1C	1	affinity chromatography technology	Ertych N (2016)	1