Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HTR3D 200909 PUMOSETRAG CHEMBL1643880 TdgClinicalTrial
HTR3D 200909 TEDATIOXETINE CHEMBL2104986 antagonist ChemblInteractions
HTR3D 200909 CHEMBL1188853 CHEMBL1188853 TdgClinicalTrial
HTR3D 200909 GRANISETRON CHEMBL289469 TdgClinicalTrial
HTR3D 200909 DOLASETRON CHEMBL2368925 TdgClinicalTrial
HTR3D 200909 RG3487 CHEMBL3544952 antagonist ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HTR3D rs7621975 A opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714428
HTR3D rs6443930 GG granisetron efficacy no Patients with cancer, treated with cisplatin who had been treated with granisetron and palonsetron. Nausea and vomiting episodes were recorded for the first 120 h post cisplatin. With regard to vomiting events, presence/absence of symptoms and the time of onset were described. Nausea severity was categorized using a 4-point Likert scale (0 = no nausea, 1 = mild nausea, 2 = moderate nausea and 3 = severe nausea) according to the subjective assessment of each patient. Genotype GG is not associated with response to granisetron or palonosetron in people with Nausea and Vomiting as compared to genotypes CC + CG. 29177570 1449170308
HTR3D rs6792482 C opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele C is not associated with dose of opioids in people with Pain as compared to allele T. 21398039 1449714414
HTR3D rs6443930 C opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele C is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714421
HTR3D rs939334 C opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Please not that alleles have been complemented to the positive strand. Allele C is not associated with dose of opioids in people with Pain as compared to allele T. 21398039 1449714407