PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAE	0	CEP250	4	affinity chromatography technology	Gloeckner CJ (2007)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
CEP250	4	GIGYF1	15	affinity chromatography technology	Fogeron ML (2013)	1
XPO1	8	YWHAG	5	affinity chromatography technology	Kirli K (2015)	1
YWHAB	1	KSR1	0	affinity chromatography technology	Couzens AL (2013)	1
YWHAE	0	KSR1	0	affinity chromatography technology	Gloeckner CJ (2007)	1
LRFN1	4	CGN	4	affinity chromatography technology	Boldt K (2016)	1
YWHAQ	0	SIK2	2	affinity chromatography technology	Henriksson E (2012)	1
ZBTB21	2	CRTC2	1	affinity chromatography technology	Boldt K (2016)	1
KSR1	0	ZBTB21	2	affinity chromatography technology	Boldt K (2016)	1
WDYHV1	0	CRTC2	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	KSR1	0	affinity chromatography technology	Kirli K (2015)	1
SIK2	2	CEP250	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Ahmed AA (2010), Ahmed AA (2010), Ahmed AA (2010)	3
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
CRTC2	1	PPP3CC	0	affinity chromatography technology	Huttlin EL (2017)	1
YWHAB	1	CRTC2	1	affinity chromatography technology, affinity chromatography technology	Jin J (2004), Couzens AL (2013)	2
TRIM25	5	CEP250	4	affinity chromatography technology	Choudhury NR (2017)	1
CDKN1A	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang B (2010), Wang B (2010), Wang B (2010)	3
CBY1	3	GIGYF1	15	affinity chromatography technology	Boldt K (2016)	1
NEDD1	1	CRTC2	1	affinity chromatography technology	Fogeron ML (2013)	1
ZBTB21	2	GIGYF1	15	affinity chromatography technology	Boldt K (2016)	1
GIGYF1	15	CRTC2	1	affinity chromatography technology	Boldt K (2016)	1
TRIM25	5	CRTC2	1	affinity chromatography technology	Choudhury NR (2017)	1
PRKAA1	2	CRTC2	1	enzymatic study	Henriksson E (2012)	1
XPO1	8	CRTC2	1	affinity chromatography technology	Kirli K (2015)	1
KIF13B	13	CRTC2	1	affinity chromatography technology	Boldt K (2016)	1
YWHAE	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
TP53	0	CLTC	12	affinity chromatography technology	Horikawa I (2014)	1
RFWD2	0	CRTC2	1	affinity chromatography technology	Dentin R (2007)	1
ZBTB21	2	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
TRIM25	5	KCTD3	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
RFWD2	0	YWHAZ	1	imaging technique, affinity chromatography technology, pull down, affinity chromatography technology	Su CH (2010), Su CH (2010), Su CH (2010), Su CH (2010)	4
CBY1	3	CRTC2	1	affinity chromatography technology	Boldt K (2016)	1
SIK2	2	YWHAE	0	affinity chromatography technology, affinity chromatography technology	Yang FC (2013), So J (2015)	2
CLTC	12	EP300	36	two hybrid, affinity chromatography technology	Wang J (2011), Hein MY (2015)	2
EGLN3	0	GTSE1	3	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	CBY1	3	affinity chromatography technology	Choudhury NR (2017)	1
LGALS3BP	5	CRTC2	1	affinity chromatography technology	Fogeron ML (2013)	1
TRIM25	5	SIK2	2	affinity chromatography technology	Choudhury NR (2017)	1
ZBTB21	2	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
CRTC2	1	CGN	4	affinity chromatography technology	Boldt K (2016)	1
NEDD1	1	LGALS3BP	5	affinity chromatography technology	Hein MY (2015)	1
EP300	36	NEDD1	1	affinity chromatography technology	Jung SY (2005)	1
YWHAB	1	RFWD2	0	pull down, affinity chromatography technology	Su CH (2011), Su CH (2011)	2
CRTC2	1	YWHAE	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	CRTC2	1	affinity chromatography technology	Rodriguez J (2016)	1
EP300	36	YWHAZ	1	enzymatic study	Mortenson JB (2015)	1
EGLN3	0	YWHAE	0	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	SIK2	2	affinity chromatography technology	Kirli K (2015)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
GIGYF1	15	CGN	4	affinity chromatography technology	Boldt K (2016)	1
KCTD3	2	CGN	4	affinity chromatography technology	Boldt K (2016)	1
CDKN1A	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, imaging technique	Zhang Z (2004), Zhang Z (2004), Zhang Z (2004), Jin Y (2003), Jin Y (2003), Wang B (2010), Xu H (2010), Xu H (2010), Frum R (2007), Chen TC (2014)	10
HECW2	13	TRIM25	5	affinity chromatography technology	Lu L (2013)	1
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
KCTD3	2	CRTC2	1	affinity chromatography technology	Boldt K (2016)	1
GTSE1	3	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
KCTD3	2	ZBTB21	2	affinity chromatography technology	Boldt K (2016)	1
CRTC2	1	PPP3R1	3	affinity chromatography technology	Huttlin EL (2017)	1
KCTD3	2	LRFN1	4	affinity chromatography technology	Boldt K (2016)	1
EGLN3	0	YWHAZ	1	affinity chromatography technology	Rodriguez J (2016)	1
CRTC2	1	EP300	36	affinity chromatography technology	Ravnskjaer K (2007)	1
CBY1	3	CGN	4	affinity chromatography technology	Boldt K (2016)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
CDKN1A	1	CRTC2	1	affinity chromatography technology	Fogeron ML (2013)	1
MDM2	2	YWHAQ	0	affinity chromatography technology, pull down, affinity chromatography technology	Pereg Y (2006), Wang B (2010), Wang B (2010)	3
TP53	0	PPP3R1	3	affinity chromatography technology	Fogeron ML (2013)	1
GIGYF1	15	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
CDKN1A	1	EP300	36	pull down, affinity chromatography technology	Cazzalini O (2008), Cazzalini O (2008)	2
PPP3CC	0	PPP3CB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
SIK2	2	YWHAZ	1	affinity chromatography technology	Yang FC (2013)	1
XPO1	8	GIGYF1	15	affinity chromatography technology	Kirli K (2015)	1
CRTC2	1	MDM2	2	affinity chromatography technology	Hallenborg P (2016)	1
XPO1	8	KCTD3	2	affinity chromatography technology	Kirli K (2015)	1
KSR1	0	KCTD3	2	affinity chromatography technology	Boldt K (2016)	1
PPP3CB	1	PPP3R1	3	affinity chromatography technology	St-Denis N (2016)	1
EGLN3	0	GIGYF1	15	affinity chromatography technology	Rodriguez J (2016)	1
PRKAA1	2	EP300	36	affinity chromatography technology	Lim JY (2012)	1
TRIM25	5	YWHAQ	0	affinity chromatography technology	Choudhury NR (2017)	1
TP53	0	HECW2	13	affinity chromatography technology	Miyazaki K (2003)	1
TRIM25	5	PPP3R1	3	affinity chromatography technology	Choudhury NR (2017)	1
KSR1	0	CGN	4	affinity chromatography technology	Boldt K (2016)	1
CLTC	12	CRTC2	1	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	GTSE1	3	affinity chromatography technology	Kirli K (2015)	1
TRIM25	5	YWHAZ	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
CGN	4	YWHAZ	1	affinity chromatography technology	Huttlin EL (2017)	1
KCTD3	2	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
YWHAG	5	ZBTB21	2	affinity chromatography technology	Jin J (2004)	1
TRIM25	5	CGN	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
EGLN3	0	SIK2	2	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	YWHAB	1	affinity chromatography technology	Choudhury NR (2017)	1
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
CGN	4	YWHAQ	0	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	CRTC2	1	affinity chromatography technology	Lv S (2016)	1
TRIM25	5	YWHAE	0	affinity chromatography technology	Choudhury NR (2017)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
TP53	0	CDKN1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Tian H (2002), Vinayagam A (2011), Kinyamu HK (2003), Giono LE (2007), Chen TC (2014)	5
EGLN3	0	KCTD3	2	affinity chromatography technology	Rodriguez J (2016)	1
CRTC2	1	PPP3CB	1	affinity chromatography technology	Huttlin EL (2017)	1
YWHAZ	1	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology	Waterman MJ (1998), Waterman MJ (1998), Gu YM (2006)	3
EGLN3	0	YWHAQ	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
TP53	0	PPP3CA	3	affinity chromatography technology	Fogeron ML (2013)	1
KSR1	0	GIGYF1	15	affinity chromatography technology	Boldt K (2016)	1
HIST1H3B	3	CRTC2	1	affinity chromatography technology	Kim SJ (2009)	1
PRKAA1	2	YWHAE	0	affinity chromatography technology	Al-Hakim AK (2005)	1
KSR1	0	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
YWHAQ	0	CEP250	4	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
KCTD3	2	GIGYF1	15	affinity chromatography technology	Boldt K (2016)	1
LRFN1	4	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
KIF13B	13	YWHAB	1	affinity chromatography technology	Yoshimura Y (2010)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
YWHAB	1	CGN	4	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2017)	2
LRFN1	4	CRTC2	1	affinity chromatography technology	Boldt K (2016)	1
LRFN1	4	GIGYF1	15	affinity chromatography technology	Boldt K (2016)	1
YWHAZ	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
KIF13B	13	CGN	4	affinity chromatography technology	Boldt K (2016)	1
CRTC2	1	PPP3CA	3	affinity chromatography technology	Lv S (2016)	1
MDM2	2	XPO1	8	affinity chromatography technology	Jacob AG (2014)	1
PPP3R1	3	PPP3CA	3	biochemical, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Rolland T (2014), Huttlin EL (2015), Yu H (2011), St-Denis N (2016), Huttlin EL (2017)	6
CRTC2	1	YWHAZ	1	affinity chromatography technology	Huttlin EL (2017)	1
CRTC2	1	SIK2	2	affinity chromatography technology, enzymatic study, enzymatic study	Screaton RA (2004), Screaton RA (2004), Henriksson E (2012)	3
YWHAQ	0	CRTC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Screaton RA (2004), Ewing RM (2007), Ichimura T (2013)	3
LRFN1	4	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
XPO1	8	NEDD1	1	affinity chromatography technology	Kirli K (2015)	1
GTSE1	3	CRTC2	1	affinity chromatography technology	Hein MY (2015)	1
ZBTB21	2	CGN	4	affinity chromatography technology	Boldt K (2016)	1
TP53	0	CRTC2	1	affinity chromatography technology	Fogeron ML (2013)	1
YWHAG	5	CRTC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004), Huttlin EL (2017)	3
YWHAQ	0	CLTC	12	pull down	Meek SE (2004)	1
MDM2	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
RFWD2	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dornan D (2006), Dornan D (2004), Dornan D (2004), Dornan D (2004), Dornan D (2004), Choi HH (2011), Yamada T (2013), Zou S (2016)	8
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
KSR1	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
CEP250	4	CRTC2	1	affinity chromatography technology	Fogeron ML (2013)	1
KSR1	0	LRFN1	4	affinity chromatography technology	Boldt K (2016)	1
HECW2	13	CRTC2	1	affinity chromatography technology	Lu L (2013)	1
YWHAB	1	TP53	0	affinity chromatography technology	Lee MK (2007)	1
ZBTB21	2	LRFN1	4	affinity chromatography technology	Boldt K (2016)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
KCTD3	2	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
PPP3CC	0	PPP3R1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	3
YWHAE	0	XPO1	8	biochemical	Kristensen AR (2012)	1
YWHAG	5	CGN	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004), Huttlin EL (2017)	3
YWHAE	0	CGN	4	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Huttlin EL (2017)	2
KSR1	0	CRTC2	1	affinity chromatography technology	Boldt K (2016)	1
TP53	0	YWHAE	0	affinity chromatography technology	Fogeron ML (2013)	1
PRKAA1	2	SIK2	2	affinity chromatography technology	Al-Hakim AK (2005)	1
CEP250	4	LGALS3BP	5	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Fogeron ML (2013)	2
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
YWHAB	1	GIGYF1	15	affinity chromatography technology	Couzens AL (2013)	1
YWHAQ	0	GIGYF1	15	affinity chromatography technology	Ichimura T (2013)	1
PRKAA1	2	YWHAZ	1	affinity chromatography technology	Al-Hakim AK (2005)	1
CBY1	3	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
TRIM25	5	RFWD2	0	affinity chromatography technology	Choudhury NR (2017)	1
YWHAZ	1	MDM2	2	affinity chromatography technology	Zhang B (2017)	1