PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP4	1	ELF4	0	two hybrid	Wang J (2011)	1
MDM2	2	SET	8	pull down	Miyamoto-Sato E (2010)	1
PML	7	NPM1	0	affinity chromatography technology	McNamara S (2008)	1
RUNX1	0	PML	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kraemer OH (2008), Nguyen LA (2005), Nguyen LA (2005), Nguyen LA (2005), Nguyen LA (2005)	5
MDM2	2	NPM1	0	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kurki S (2004), Kurki S (2004), Nicholson J (2012), Nicholson J (2012)	4
PML	7	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bernardi R (2004), Bernardi R (2004), Zhu H (2003), Zhu H (2003), Kurki S (2003), Kurki S (2003), Wei X (2003), Wei X (2003), Wu Q (2009), Chu Y (2011), Yang Q (2013), Yang Q (2013), Bursac S (2012)	13
NPM1	0	ELF4	0	affinity chromatography technology, pull down, pull down	Ando K (2013), Ando K (2013), Ando K (2013)	3
KDM5B	27	ELF4	0	affinity chromatography technology	Zhou W (2009)	1
ELF4	0	PML	7	affinity chromatography technology, affinity chromatography technology	Suico MA (2004), Suico MA (2004)	2
MDM2	2	ELF4	0	affinity chromatography technology, affinity chromatography technology	Suico MA (2014), Suico MA (2014)	2
ELF4	0	SET	8	two hybrid	Wang J (2011)	1
RUNX1	0	ELF4	0	affinity chromatography technology, pull down	Mao S (1999), Mao S (1999)	2
SKP2	2	ELF4	0	affinity chromatography technology, enzymatic study	Liu Y (2006), Liu Y (2006)	2