PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL2	4	ELAVL3	3	affinity chromatography technology	Huttlin EL (2017)	1
RNF32	0	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
NTRK1	1	SRPK2	1	affinity chromatography technology	Emdal KB (2015)	1
MAST1	9	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
NTRK1	1	EWSR1	2	affinity chromatography technology	Emdal KB (2015)	1
NOS3	7	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
ELAVL3	3	EWSR1	2	two hybrid	Rual JF (2005)	1
NTRK1	1	ELAVL3	3	affinity chromatography technology	Emdal KB (2015)	1
ECSIT	3	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	CDC37	0	affinity chromatography technology, two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CDC37	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
SRPK2	1	ELAVL3	3	enzymatic study	Lipp JJ (2015)	1
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
EWSR1	2	CDC37	0	bioid	Elzi DJ (2014)	1
CDC37	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
NTRK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2
ELAVL3	3	PEX14	2	biochemical	Wan C (2015)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1