PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	MAPK14	0	affinity chromatography technology	Choudhury NR (2017)	1
LRRK2	5	EIF4EBP1	1	enzymatic study, enzymatic study	Kumar A (2010), Imai Y (2008)	2
PRKDC	12	ATM	9	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Suzuki K (1999), Suzuki K (1999)	3
LRRK2	5	AKT1	1	enzymatic study, pull down	Ohta E (2011), Ohta E (2011)	2
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
PRKDC	12	AKT2	1	enzymatic study, enzymatic study	Hresko RC (2005), Dragoi AM (2005)	2
PRKDC	12	GSK3B	1	enzymatic study	Dragoi AM (2005)	1
MTOR	14	PRKDC	12	genetic interference	Shen JP (2017)	1
LRRK2	5	PRKDC	12	affinity chromatography technology, affinity chromatography technology	Daechsel JC (2007), Sen S (2009)	2
AKT2	1	GGA1	0	biochemical	Wan C (2015)	1
PRKDC	12	EIF4EBP1	1	enzymatic study	Chan DW (2000)	1
STK3	1	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Romano D (2010), Romano D (2010), Kim D (2010), Kim D (2010), Kim D (2010)	5
MAPK1	1	RPTOR	4	enzymatic study, pull down, enzymatic study	Carriere A (2011), Carriere A (2011), Langlais P (2011)	3
SLMAP	3	EIF4EBP1	1	bioid	Couzens AL (2013)	1
TRIM25	5	DDX1	6	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	MAPK1	1	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPA1	1	HNRNPAB	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Roy R (2014), Hein MY (2015)	3
EIF4EBP1	1	TCF4	26	two hybrid	Rolland T (2014)	1
BUB1	3	EIF4EBP1	1	imaging technique	Chen TC (2014)	1
AGO2	10	EIF4EBP1	1	affinity chromatography technology	Gehrke S (2010)	1
TRIM25	5	AGO2	10	affinity chromatography technology	Choudhury NR (2017)	1
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
TRIM25	5	GGA1	0	affinity chromatography technology	Choudhury NR (2017)	1
MAPK1	1	MTOR	14	genetic interference	Srivas R (2016)	1
MLST8	1	EIF4EBP1	1	enzymatic study	Choo AY (2008)	1
TRIM25	5	PRKDC	12	affinity chromatography technology	Choudhury NR (2017)	1
LRRK2	5	AGO2	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gehrke S (2010), Gehrke S (2010), Daechsel JC (2007)	3
GSK3B	1	MTOR	14	two hybrid	Vinayagam A (2011)	1
AKT1	1	GSK3B	1	pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Thimmaiah KN (2005), Drendall CI (2010), Connor MK (2005), Hunter MG (2004), Zhu QS (2011), Li L (2003), Nam SY (2010), Yang WL (2009), Zeng L (2013), Yang H (2005), Boehme KA (2008), Cross DA (1995), Hinton CV (2007), Kapoor GS (2004), Pitre A (2012), Guo J (2016)	16
PRKCA	7	EIF4EBP1	1	enzymatic study	Rininsland F (2005)	1
MAPKAPK5	0	EIF4EBP1	1	imaging technique	Chen TC (2014)	1
MTOR	14	EIF4EBP1	1	pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Schalm SS (2003), Kim DH (2002), Long X (2005), Hara K (2002), Takahashi T (2000), Burnett PE (1998), Hara K (2002), Wang L (2006), Wang X (2005), Oshiro N (2004), Wang L (2006), McMahon LP (2005), Dunlop EA (2011), Eguchi S (2006), Lee DF (2007), Wang X (2005), Carriere A (2008), Choi KM (2003), Nojima H (2003), Smith EM (2008), Bai X (2007), Thedieck K (2007), Choo AY (2008), Evdokimova V (2006), Koren I (2010), Sancak Y (2007), Rui YN (2015)	27
AKT1	1	MAPK14	0	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Rane MJ (2001), Rane MJ (2001), Hartman AD (2006), Rane MJ (2001), Rane MJ (2001), Ivanov AA (2017)	6
HNRNPA1	1	EIF4EBP1	1	biochemical	Wan C (2015)	1
MTOR	14	MLST8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sarbassov DD (2005), Oshiro N (2004), Kawai S (2003), Kawai S (2003), Kaizuka T (2010), Behrends C (2010), Wang L (2006), McMahon LP (2005), Kim DH (2003), Kim DH (2003), Kim DH (2003), Peterson TR (2009), Yan X (2012), Ramirez-Rangel I (2011), Martin J (2008), Thedieck K (2007), Loewith R (2002), Glidden EJ (2012), Vander Haar E (2007), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016), Wang B (2017)	23
DDX1	6	ATM	9	affinity chromatography technology, pull down	Li L (2008), Li L (2008)	2
AKT1	1	AKT2	1	affinity chromatography technology	Huttlin EL (2017)	1
PRKCA	7	GSK3B	1	enzymatic study	Goode N (1992)	1
PPP2R2A	0	EIF4EBP1	1	affinity chromatography technology	Bishop JD (2006)	1
AKT1	1	EIF4EBP1	1	imaging technique	Chen TC (2014)	1
DDX1	6	EIF4EBP1	1	biochemical	Wan C (2015)	1
TRIM25	5	UBAC1	2	affinity chromatography technology	Choudhury NR (2017)	1
LRPAP1	2	EIF4EBP1	1	affinity chromatography technology	Wang L (2006)	1
TRIM25	5	CHTF8	1	affinity chromatography technology	Choudhury NR (2017)	1
MTOR	14	PRKCA	7	enzymatic study	Oh WJ (2010)	1
TRIM25	5	EIF4EBP1	1	affinity chromatography technology	Choudhury NR (2017)	1
PTPA	0	AKT1	1	enzymatic study, enzymatic study	Ma Y (2007), Li L (2003)	2
TRIM14	1	EIF4EBP1	1	bioid	Tan P (2017)	1
HNRNPA1	1	DDX1	6	affinity chromatography technology, biochemical, affinity chromatography technology	Close P (2012), Havugimana PC (2012), Roy R (2014)	3
TRIM25	5	MTOR	14	affinity chromatography technology	Choudhury NR (2017)	1
MAPKAPK5	0	MAPK1	1	imaging technique	Chen TC (2014)	1
GGA1	0	EIF4EBP1	1	biochemical	Wan C (2015)	1
SHMT2	3	DDX1	6	biochemical	Wan C (2015)	1
CCDC94	0	EIF4EBP1	1	biochemical	Wan C (2015)	1
TRIM25	5	PTPA	0	affinity chromatography technology	Choudhury NR (2017)	1
AKT2	1	EIF4EBP1	1	biochemical	Wan C (2015)	1
TRIM25	5	RPTOR	4	affinity chromatography technology	Choudhury NR (2017)	1
LATS1	3	EIF4EBP1	1	enzymatic study	Chiyoda T (2012)	1
TRIM25	5	FLNB	11	affinity chromatography technology	Choudhury NR (2017)	1
MAPK1	1	EIF4EBP1	1	enzymatic study	Choi KM (2003)	1
GSK3B	1	AKT2	1	x-ray crystallography	Yang J (2002)	1
SHMT2	3	EIF4EBP1	1	biochemical	Wan C (2015)	1
LRRK2	5	STK3	1	enzymatic study	Zach S (2010)	1
AKT3	3	EIF4EBP1	1	biochemical	Wan C (2015)	1
MTOR	14	PPP2R2A	0	pull down	Peterson RT (1999)	1
SHMT2	3	HNRNPAB	4	affinity chromatography technology	Castello A (2012)	1
AKT1	1	RPTOR	4	affinity chromatography technology	Kim EK (2011)	1
FLNB	11	GGA1	0	biochemical	Wan C (2015)	1
RPTOR	4	EIF4E	1	affinity chromatography technology	Wang L (2006)	1
ATM	9	PRKCA	7	genetic interference	Ye H (2016)	1
IRAK4	0	EIF4EBP1	1	enzymatic study	Rininsland F (2005)	1
STK3	1	EIF4EBP1	1	enzymatic study	Kumar A (2010)	1
ATM	9	MAPK14	0	affinity chromatography technology	Zhang S (2006)	1
EIF4E	1	MTOR	14	affinity chromatography technology	Ma XM (2008)	1
PRKDC	12	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference	Feng J (2004), Feng J (2004), Feng J (2004), Dragoi AM (2005), Dragoi AM (2005), Dragoi AM (2005), Shen JP (2017)	7
MLST8	1	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Gwinn DM (2010), Wang L (2006), Hernandez-Negrete I (2007), Ramirez-Rangel I (2011), Coffman K (2014), Loewith R (2002), Loewith R (2002), Thedieck K (2007), Wang B (2017)	10
SHMT2	3	MTOR	14	affinity chromatography technology	Castello A (2012)	1
EIF4EBP1	1	CHTF8	1	two hybrid	Rual JF (2005)	1
FLNB	11	EIF4EBP1	1	biochemical	Wan C (2015)	1
STK3	1	LATS1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Matallanas D (2011), Guo C (2007), Guo C (2007), Hamilton G (2009), Chan EH (2005)	5
TRIM25	5	HNRNPA1	1	affinity chromatography technology	Choudhury NR (2017)	1
GSK3B	1	EIF4EBP1	1	two hybrid	Vinayagam A (2011)	1
PRKDC	12	HNRNPA1	1	enzymatic study	Zhang S (2004)	1
RPTOR	4	EIF4EBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, enzymatic study, far western blotting, pull down, affinity chromatography technology, enzymatic study	Schalm SS (2003), Ha SH (2006), Eguchi S (2006), Beugnet A (2003), Schalm SS (2003), Hara K (2002), Hara K (2002), Wang L (2006), Wang X (2005), Nojima H (2003), Kwak D (2012), Wang L (2006), Carriere A (2011), Carriere A (2008), Choi KM (2003), Beugnet A (2003), Beugnet A (2003), Land SC (2007), Smith EM (2008), Smith EM (2008), Coffman K (2014), Coffman K (2014), Choo AY (2008)	23
AKT1	1	MTOR	14	pull down, unspecified method, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, imaging technique	Sekulic A (2000), Cheng SW (2004), Oh WJ (2010), Sarbassov DD (2005), Ikenoue T (2008), Murata H (2011), Martin J (2008), Facchinetti V (2008), Facchinetti V (2008), Chen CH (2011), Xu Y (2013), Glidden EJ (2012), Chen TC (2014), Pitre A (2012), Moon HE (2015)	15
EIF4EBP1	1	KLHL25	6	affinity chromatography technology	Yanagiya A (2012)	1
ATM	9	EIF4EBP1	1	unspecified method, enzymatic study	Kim ST (1999), Chan DW (2000)	2
SLMAP	3	STK3	1	affinity chromatography technology, bioid, two hybrid	Couzens AL (2013), Couzens AL (2013), Rolland T (2014)	3
AKT3	3	AKT1	1	affinity chromatography technology	Huttlin EL (2017)	1
EIF4EBP1	1	UBAC1	2	affinity chromatography technology	Ewing RM (2007)	1
LRPAP1	2	MTOR	14	affinity chromatography technology	Wang L (2006)	1
EIF4E	1	EIF4EBP1	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, pull down, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Mader S (1995), Rao RD (2005), Eguchi S (2006), Yang D (1999), Patel J (2002), Kumar V (2000), Kumar V (2000), Gingras AC (1999), Connolly E (2006), Shen X (2001), Adegoke OA (2009), Kroczynska B (2012), Wang X (2003), Wang L (2006), Eguchi S (2006), Wang X (2005), Corominas R (2014), Kucejova B (2011), Petersson J (2012), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Tang X (2003), Huttlin EL (2017)	26
TRIM25	5	LRPAP1	2	affinity chromatography technology	Choudhury NR (2017)	1
ATM	9	PTPA	0	affinity chromatography technology	Aglipay JA (2006)	1
MAPK14	0	EIF4EBP1	1	enzymatic study	Kumar A (2010)	1
MAPK1	1	GSK3B	1	affinity chromatography technology, pull down, enzymatic study	Ding Q (2005), Ding Q (2005), Ding Q (2005)	3
MAPK14	0	MAPKAPK5	0	two hybrid	Bandyopadhyay S (2010)	1
PTPA	0	EIF4EBP1	1	enzymatic study	Smith EM (2008)	1
EIF4EBP1	1	REL	5	two hybrid	Rolland T (2014)	1
TRIM25	5	MLST8	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HNRNPAB	4	affinity chromatography technology	Choudhury NR (2017)	1
CHMP2A	3	EIF4EBP1	1	biochemical	Wan C (2015)	1
AKT3	3	GSK3B	1	enzymatic study, enzymatic study	Dragoi AM (2005), Guo J (2016)	2
EIF4EBP1	1	HNRNPAB	4	biochemical	Wan C (2015)	1