PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DDX31	1	AHSG	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMA3	1	AHSG	0	affinity chromatography technology	Fedorova OA (2011)	1
CA8	0	ALB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK6	1	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
INSR	9	AHSG	0	pull down	Srinivas PR (1993)	1
EGFR	5	AHSG	0	affinity chromatography technology	Yao Z (2017)	1
AHSG	0	POTEF	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CA8	0	AHSG	0	affinity chromatography technology	Huttlin EL (2017)	1
USP38	2	AHSG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
PSMA3	1	ALB	1	affinity chromatography technology	Fedorova OA (2011)	1
CDC42	3	AHSG	0	two hybrid	Wang J (2008)	1
SOD1	0	ALB	1	affinity chromatography technology	Hein MY (2015)	1
INSR	9	GRB2	2	affinity chromatography technology	Ishihara H (1997)	1
ALB	1	AHSG	0	affinity chromatography technology	Zhou M (2004)	1
EGFR	5	PSMA3	1	affinity chromatography technology	Yao Z (2017)	1
SNX27	5	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
ATF2	1	AHSG	0	affinity chromatography technology	Lau E (2012)	1
MAPK6	1	CDC42	3	affinity chromatography technology	Rodriguez J (2016)	1
SOD1	0	CDC42	3	affinity chromatography technology	Malty RH (2017)	1
DCN	0	EGFR	5	two hybrid, pull down, pull down	Santra M (2002), Santra M (2002), Iozzo RV (1999)	3
GRB2	2	AHSG	0	two hybrid	Wang J (2008)	1
GRB2	2	CDC42	3	two hybrid	Vinayagam A (2011)	1
DCN	0	AHSG	0	pull down	Sugars RV (2002)	1
GRB2	2	PPP5C	2	affinity chromatography technology	Bisson N (2011)	1
GDPD1	0	AHSG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK6	1	AHSG	0	affinity chromatography technology	Huttlin EL (2017)	1
SOD1	0	AHSG	0	affinity chromatography technology	Malty RH (2017)	1
VKORC1	1	AHSG	0	two hybrid	Schaafhausen A (2011)	1
FBXO2	0	AHSG	0	pull down, enzymatic study, enzymatic study	Yoshida Y (2002), Yoshida Y (2002), Tai T (2006)	3
AHSG	0	PPP5C	2	biochemical	Havugimana PC (2012)	1
EGFR	5	PPP5C	2	protein complementation assay	Deribe YL (2009)	1
SNX27	5	INSR	9	affinity chromatography technology	Ghai R (2013)	1
SNX27	5	AHSG	0	affinity chromatography technology	Huttlin EL (2017)	1
DDX31	1	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
GDPD1	0	ALB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2