PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCDC60	1	DCP1B	1	affinity chromatography technology	Huttlin EL (2017)	1
EDC3	1	EDC4	4	affinity chromatography technology, biochemical	Fenger-Gron M (2005), Fenger-Gron M (2005)	2
CBY1	3	DCP1A	1	affinity chromatography technology	Boldt K (2016)	1
LPXN	4	DCP1B	1	affinity chromatography technology	Huttlin EL (2017)	1
STIL	3	DCP1B	1	bioid	Gupta GD (2015)	1
UPF2	2	DCP1B	1	two hybrid	Lehner B (2004)	1
BTRC	1	DCP1A	1	bioid	Coyaud E (2015)	1
CENPJ	6	DCP1B	1	bioid	Gupta GD (2015)	1
MCM2	3	ERP44	1	affinity chromatography technology	Drissi R (2015)	1
USP4	3	EDC3	1	affinity chromatography technology	Sowa ME (2009)	1
DCP1B	1	HSPA1L	2	affinity chromatography technology	Fenger-Gron M (2005)	1
SMAD4	9	USP4	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhou F (2017), Zhou F (2017), Zhou F (2017), Zhou F (2017)	4
SMAD4	9	DCP1B	1	two hybrid	Colland F (2004)	1
MIR15B	0	DCP2	0	affinity chromatography technology	Treiber T (2017)	1
CENPJ	6	XRN1	4	bioid	Gupta GD (2015)	1
CENPJ	6	STIL	3	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
ZFP36	2	DCP1A	1	affinity chromatography technology	Fenger-Gron M (2005)	1
NINL	1	KANK2	4	bioid	Gupta GD (2015)	1
PIM1	2	DCP1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	EDC3	1	affinity chromatography technology	Kirli K (2015)	1
DCP1A	1	SMAD4	9	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Bai RY (2002), Bai RY (2002), Bai RY (2002), Colland F (2004), Li X (2015)	5
MCM2	3	HSPA1L	2	affinity chromatography technology	Drissi R (2015)	1
UPF2	2	DCP2	0	affinity chromatography technology, two hybrid	Lejeune F (2003), Lehner B (2004)	2
DCP1B	1	PNRC1	0	affinity chromatography technology	Li S (2014)	1
GRN	2	DCP1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BTRC	1	ZNF704	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loveless TB (2015), Loveless TB (2015), Huttlin EL (2017)	3
KCTD3	2	CGN	4	affinity chromatography technology	Boldt K (2016)	1
XPO1	8	DDX6	0	affinity chromatography technology	Kirli K (2015)	1
XRN1	4	EXOSC6	0	two hybrid	Lehner B (2004)	1
XPO1	8	DCP1A	1	affinity chromatography technology	Kirli K (2015)	1
EDC3	1	KCTD3	2	affinity chromatography technology	Boldt K (2016)	1
BTRC	1	DCP1B	1	bioid	Coyaud E (2015)	1
PIM1	2	EDC3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP4	3	LSM8	0	affinity chromatography technology	Sowa ME (2009)	1
BAG4	2	DDX6	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
MIR15B	0	EDC3	1	affinity chromatography technology	Treiber T (2017)	1
DCP1A	1	DDX6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Li S (2014), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CBY1	3	CGN	4	affinity chromatography technology	Boldt K (2016)	1
UPF2	2	XRN1	4	affinity chromatography technology	Lejeune F (2003)	1
STIL	3	EDC3	1	bioid	Gupta GD (2015)	1
DCP2	0	DCP1B	1	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Lehner B (2004), Lehner B (2004), Li S (2014), Huttlin EL (2015), Huttlin EL (2017)	6
BAG4	2	EDC4	4	affinity chromatography technology	Huttlin EL (2017)	1
DCP2	0	DCP1A	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lykke-Andersen J (2002), Lykke-Andersen J (2002), Lykke-Andersen J (2002), Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Lehner B (2004), Li S (2014), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Hein MY (2015), Tenekeci U (2016), Huttlin EL (2017)	14
HSPA1L	2	XPO1	8	biochemical	Kristensen AR (2012)	1
ZFP36	2	DCP1B	1	two hybrid	Holmes B (2012)	1
DCP1B	1	E2F7	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ERP44	1	DCP1B	1	affinity chromatography technology	Huttlin EL (2017)	1
STIL	3	BTRC	1	bioid	Gupta GD (2015)	1
XPO1	8	DCP1B	1	affinity chromatography technology	Kirli K (2015)	1
EXOSC6	0	ZFP36	2	two hybrid	Lehner B (2004)	1
EXOSC6	0	DCP1B	1	two hybrid	Lehner B (2004)	1
KCTD3	2	DCP1B	1	affinity chromatography technology	Boldt K (2016)	1
DCP1B	1	DDX6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Huttlin EL (2017)	5
DCP1B	1	DCP1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Li S (2014), Li S (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	8
XPO1	8	KCTD3	2	affinity chromatography technology	Kirli K (2015)	1
DCP1B	1	CGN	4	affinity chromatography technology	Boldt K (2016)	1
NINL	1	HSPA1L	2	bioid	Gupta GD (2015)	1
DDX6	0	EDC4	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM167A	1	DCP1B	1	affinity chromatography technology	Huttlin EL (2017)	1
KIF13B	13	DCP1B	1	affinity chromatography technology	Boldt K (2016)	1
XRN1	4	DCP1B	1	two hybrid	Lehner B (2004)	1
ZFP36	2	EDC3	1	affinity chromatography technology	Fenger-Gron M (2005)	1
BTRC	1	SMAD4	9	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wan M (2004), Wan M (2004), Yang L (2006), Yang L (2006), Wan M (2005), Liang M (2004), Demagny H (2014), Li D (2015)	8
CCDC102B	0	DCP1B	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	KANK2	4	affinity chromatography technology	Kirli K (2015)	1
BAG4	2	HSPA1L	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
KCTD3	2	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
MIR15B	0	DCP1B	1	affinity chromatography technology	Treiber T (2017)	1
STIL	3	XRN1	4	bioid	Gupta GD (2015)	1
MCM2	3	DDX6	0	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	DCP1B	1	affinity chromatography technology	Drissi R (2015)	1
XPO1	8	ZFP36	2	affinity chromatography technology	Kirli K (2015)	1
DCP1A	1	EDC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Li S (2014), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Hein MY (2015), Tenekeci U (2016), Tenekeci U (2016), Huttlin EL (2017)	13
MCM2	3	BAG4	2	affinity chromatography technology	Drissi R (2015)	1
LSM8	0	EXOSC6	0	two hybrid	Lehner B (2004)	1
DCP1A	1	PNRC1	0	affinity chromatography technology, affinity chromatography technology	Li S (2014), Hein MY (2015)	2
UPF2	2	ZFP36	2	two hybrid	Lehner B (2004)	1
KCTD3	2	DCP1A	1	affinity chromatography technology	Boldt K (2016)	1
NINL	1	CENPJ	6	bioid	Gupta GD (2015)	1
SH3BGR	0	DCP1B	1	affinity chromatography technology	Huttlin EL (2017)	1
BTRC	1	KANK2	4	bioid	Coyaud E (2015)	1
DCP1B	1	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
MCM2	3	XPO1	8	affinity chromatography technology	Drissi R (2015)	1
KIF13B	13	CGN	4	affinity chromatography technology	Boldt K (2016)	1
LPXN	4	EDC3	1	affinity chromatography technology	Huttlin EL (2017)	1
NSMAF	5	DCP1B	1	two hybrid, pull down	Steffens A (2015), Steffens A (2015)	2
BOD1	1	DCP1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCP1B	1	LSM8	0	two hybrid	Lehner B (2004)	1
CCDC102B	0	CGN	4	affinity chromatography technology	Huttlin EL (2017)	1
EDC3	1	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
XRN1	4	DCP1A	1	two hybrid, imaging technique, affinity chromatography technology	Lehner B (2004), Tenekeci U (2016), Tenekeci U (2016)	3
EDC4	4	DCP2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bloch DB (2011), Bloch DB (2011), Fenger-Gron M (2005), Fenger-Gron M (2005), Lehner B (2004), Li S (2014), Li S (2014), Huttlin EL (2015), Huttlin EL (2017)	9
ZNF704	2	DCP1B	1	affinity chromatography technology	Huttlin EL (2017)	1
DCP1B	1	EDC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Fenger-Gron M (2005), Li S (2014), Taipale M (2014), Taipale M (2014), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	8
MIR15B	0	DCP1A	1	affinity chromatography technology	Treiber T (2017)	1
LSM8	0	DCP1A	1	two hybrid	Lehner B (2004)	1
IRF2BP1	4	DCP1B	1	affinity chromatography technology	Huttlin EL (2017)	1
EDC4	4	DCP1B	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Bloch DB (2011), Bloch DB (2011), Taipale M (2014), Taipale M (2014)	4
EDC3	1	DCP2	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Huttlin EL (2015), Huttlin EL (2017)	4
EDC3	1	DDX6	0	affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
DCP1B	1	BAG4	2	affinity chromatography technology, affinity chromatography technology	Li S (2014), Huttlin EL (2017)	2
GRN	2	EDC3	1	affinity chromatography technology	Huttlin EL (2017)	1
USP4	3	DCP1A	1	affinity chromatography technology	Sowa ME (2009)	1
NINL	1	DCP1B	1	bioid	Gupta GD (2015)	1
XPO1	8	EDC4	4	affinity chromatography technology	Kirli K (2015)	1
DCP1A	1	BAG4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Huttlin EL (2017)	5
UPF2	2	EXOSC6	0	two hybrid	Lehner B (2004)	1
BAG4	2	EDC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2017)	3
KCTD3	2	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
PIM1	2	DDX6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCP1A	1	EDC4	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Fenger-Gron M (2005), Fenger-Gron M (2005), Fenger-Gron M (2005), Li S (2014), Li S (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Tenekeci U (2016), Tenekeci U (2016)	10
XRN1	4	ZFP36	2	two hybrid, two hybrid	Lehner B (2004), Holmes B (2012)	2
NINL	1	XRN1	4	bioid	Gupta GD (2015)	1
XPO1	8	UPF2	2	affinity chromatography technology	Kirli K (2015)	1
DDX6	0	PNRC1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LSM8	0	KCTD3	2	two hybrid	Lehner B (2004)	1
ZFP36	2	EDC4	4	affinity chromatography technology	Fenger-Gron M (2005)	1
CCDC102B	0	EDC3	1	affinity chromatography technology	Huttlin EL (2017)	1
USP4	3	DCP1B	1	affinity chromatography technology	Sowa ME (2009)	1
CBY1	3	DCP1B	1	affinity chromatography technology	Boldt K (2016)	1
DCP1A	1	HSPA1L	2	affinity chromatography technology	Fenger-Gron M (2005)	1
XPO1	8	XRN1	4	affinity chromatography technology	Kirli K (2015)	1
DCP1A	1	KANK2	4	affinity chromatography technology	Li S (2014)	1
CBY1	3	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
XPO1	8	SMAD4	9	affinity chromatography technology	Kirli K (2015)	1
KIF13B	13	DCP1A	1	affinity chromatography technology	Boldt K (2016)	1
MIR15B	0	EDC4	4	affinity chromatography technology	Treiber T (2017)	1
ZFP36	2	DCP2	0	affinity chromatography technology	Fenger-Gron M (2005)	1
DCP1B	1	KANK2	4	affinity chromatography technology	Li S (2014)	1
PIM1	2	DCP1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NSMAF	5	DCP1A	1	two hybrid, pull down	Steffens A (2015), Steffens A (2015)	2
EDC3	1	CBY1	3	affinity chromatography technology	Boldt K (2016)	1