Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
EDN1 1906 DEFEROXAMINE CHEMBL556 NCI 9112092
EDN1 1906 MURAGLITAZAR CHEMBL186179 PharmGKB
EDN1 1906 LANREOTIDE CHEMBL1201185 NCI 17051749
EDN1 1906 ETIOCHOLANOLONE CHEMBL85799 agonist GuideToPharmacologyInteractions
EDN1 1906 CELECOXIB CHEMBL118 NCI 15539607
EDN1 1906 DOXORUBICIN CHEMBL53463 NCI 11589785
EDN1 1906 ALPROSTADIL CHEMBL495 NCI 8213257
EDN1 1906 TAMOXIFEN CHEMBL83 NCI 8425178
EDN1 1906 THIOURACIL CHEMBL345768 NCI 10967532
EDN1 1906 CANDESARTAN CILEXETIL CHEMBL1014 NCI 10029562
EDN1 1906 BUDESONIDE CHEMBL1370 NCI 7716352

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
EDN1 rs5370 GT atenolol efficacy no No significant difference in the change in diastolic blood pressure (DBP) between genotypes was seen, between baseline and 12 weeks. p-value was adjusted for age, dose, and systolic blood pressure, DBP, and left ventricular mass index (LVMI) at baseline. Genotype GT is not associated with response to atenolol and irbesartan in men with Essential hypertension as compared to genotype GG. 15188945 982043114
EDN1 rs5370 GT + TT atenolol efficacy yes No significant difference in the change in systolic blood pressure (SBP) or diastolic blood pressure (DBP) between genotypes was seen, between baseline and 12 weeks. p-value was adjusted for age, dose, and SBP, DBP and left ventricular mass index (LVMI) at baseline. Genotypes GT + TT are not associated with response to atenolol and irbesartan in women with Essential hypertension as compared to genotype GG. 15188945 982043126
EDN1 rs5370 GT atenolol efficacy yes Men with the GT genotype had a greater reduction in systolic blood pressure (SBP) between baseline and 12 weeks of treatment, as compared to those with the GG genotype. p-value was adjusted for age, dose, and SBP, diastolic blood pressure and left ventricular mass index (LVMI) at baseline. Genotype GT is associated with increased response to atenolol and irbesartan in men with Essential hypertension as compared to genotype GG. 15188945 982043089