PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ABCA1	5	SPTLC1	1	affinity chromatography technology	Tamehiro N (2008)	1
ABCA1	5	HGS	5	affinity chromatography technology	Mizuno T (2011)	1
CSNK2A2	1	ABCA1	5	enzymatic study	Roosbeek S (2004)	1
ABCA1	5	AOX1	1	two hybrid	Buechler C (2002)	1
ABCA1	5	FLOT1	0	affinity chromatography technology	Bared SM (2004)	1
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
ABCA1	5	SNTB2	4	two hybrid, affinity chromatography technology	Buechler C (2002), Buechler C (2002)	2
ABCA1	5	NR1H2	2	affinity chromatography technology, affinity chromatography technology	Mogilenko DA (2010), Mizuno T (2015)	2
LNX1	7	ABCA1	5	enzymatic study	Guo Z (2012)	1
ABCA1	5	PRPF8	14	two hybrid	Buechler C (2002)	1
EGFR	5	ABCA1	5	affinity chromatography technology	Yao Z (2017)	1
ABCA1	5	SDHB	0	two hybrid	Buechler C (2002)	1
RELA	1	ABCA1	5	affinity chromatography technology	Veena MS (2014)	1
ATXN10	3	ABCA1	5	two hybrid	Waragai M (2006)	1
ABCA1	5	UGP2	2	two hybrid	Buechler C (2002)	1
EGFR	5	FUS	0	affinity chromatography technology	Liccardi G (2014)	1
ABCA1	5	STX12	2	affinity chromatography technology, affinity chromatography technology	Bared SM (2004), Bared SM (2004)	2
ABCA1	5	TGM2	2	two hybrid	Wang J (2011)	1
COPS5	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Christmann M (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Scherer PC (2016), Huttlin EL (2017), Boldt K (2016)	15
EGFR	5	SPTLC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014), Yao Z (2017)	3
ABCA1	5	COPS5	0	affinity chromatography technology, affinity chromatography technology	Azuma Y (2009), Azuma Y (2009)	2
FUS	0	RELA	1	affinity chromatography technology, pull down	Uranishi H (2001), Uranishi H (2001)	2
FUS	0	ABCA1	5	affinity chromatography technology	Wang T (2014)	1
COPS5	0	FUS	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS2	5	ABCA1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Azuma Y (2009), Zhang M (2016), Zhang M (2016)	3
RELA	1	TGM2	2	affinity chromatography technology, imaging technique	Kumar S (2012), Kumar S (2012)	2
LNX1	7	FLOT1	0	affinity chromatography technology	Lenihan JA (2017)	1
HGS	5	STX12	2	affinity chromatography technology	Sun W (2003)	1
APOA1	0	ABCA1	5	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Fitzgerald ML (2002), Fitzgerald ML (2002), Zhang M (2016), Zhang M (2016)	4
ABCA1	5	IKBKG	0	two hybrid	Wang J (2011)	1
IKBKG	0	FADD	1	affinity chromatography technology	Biton S (2011)	1
ABCA1	5	FADD	1	two hybrid, pull down, pull down	Buechler C (2002), Buechler C (2002), Buechler C (2002)	3
CSNK2A2	1	RELA	1	affinity chromatography technology, enzymatic study	Wang D (2000), Wang D (2000)	2
IKBKG	0	RELA	1	enzymatic study	Dan HC (2008)	1
ABCA1	5	CDC42	3	affinity chromatography technology	Nofer JR (2006)	1
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
EGFR	5	ATXN10	3	affinity chromatography technology	Foerster S (2013)	1
CSNK2A2	1	TGM2	2	two hybrid	Wang J (2011)	1
ERBIN	5	ABCA1	5	unspecified method	Boisguerin P (2004)	1
COPS5	0	SDHB	0	affinity chromatography technology	Bennett EJ (2010)	1