PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CSNK1D	3	SMAD4	9	affinity chromatography technology	Ding L (2009)	1
DVL2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Wei W (2012), Wei W (2012), Wei W (2012), Mund T (2015), Mund T (2015), Mund T (2015)	6
DVL1	5	DVL3	7	two hybrid, affinity chromatography technology, pull down	Kishida S (1999), Kishida S (1999), Kishida S (1999)	3
CEP128	1	CSNK1E	0	bioid	Gupta GD (2015)	1
CSNK1E	0	DVL2	5	two hybrid, affinity chromatography technology	Rual JF (2005), Varjosalo M (2013)	2
SMAD7	1	CTNNB1	30	affinity chromatography technology, imaging technique, affinity chromatography technology	Edlund S (2005), Edlund S (2005), Tang Y (2008)	3
ATN1	2	WWP2	7	two hybrid, pull down, two hybrid	Wood JD (1998), Wood JD (1998), Lim J (2006)	3
CEP135	2	KIAA0753	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
XPO1	8	RASSF9	0	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	CSNK1E	0	affinity chromatography technology	Kirli K (2015)	1
CEP128	1	CYLD	2	bioid	Gupta GD (2015)	1
SSX2IP	0	NUMA1	10	affinity chromatography technology	Gupta GD (2015)	1
SMAD2	5	DAB2	1	pull down, affinity chromatography technology	Hocevar BA (2001), Hocevar BA (2001)	2
RASSF10	2	CSNK2A1	15	affinity chromatography technology	Hauri S (2013)	1
SMAD7	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lallemand F (2005), Lallemand F (2005), Al-Salihi MA (2012), Gen Y (2017), Gen Y (2017)	5
CEP128	1	DVL3	7	bioid	Gupta GD (2015)	1
SMAD2	5	DVL1	5	pull down	Warner DR (2003)	1
CEP135	2	DVL3	7	bioid	Gupta GD (2015)	1
SDC4	0	DVL1	5	affinity chromatography technology	Carvallo L (2010)	1
DAB2	1	DVL3	7	pull down, affinity chromatography technology	Hocevar BA (2003), Hocevar BA (2003)	2
CTNNB1	30	SIRT1	3	affinity chromatography technology	Holloway KR (2010)	1
SMAD3	1	BTRC	1	affinity chromatography technology	Wan M (2004)	1
DVL1	5	CTNNB1	30	affinity chromatography technology, imaging technique	Song DH (2000), Chen TC (2014)	2
BTRC	1	WWOX	3	bioid	Coyaud E (2015)	1
CEP44	2	DVL1	5	bioid	Gupta GD (2015)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
CSNK1D	3	DVL3	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
AHI1	4	DVL1	5	bioid	Gupta GD (2015)	1
SIRT1	3	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology	Holloway KR (2010), Kang H (2009)	2
SMAD2	5	CSNK1D	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Brown KA (2008), Ding L (2009), Ding L (2009)	3
DVL1	5	TRIM69	0	two hybrid	Rolland T (2014)	1
DVL1	5	PSMA3	1	two hybrid	Wang J (2011)	1
AXIN1	1	DVL2	5	affinity chromatography technology	Zhang Y (2000)	1
CEP44	2	DVL2	5	bioid	Gupta GD (2015)	1
AXIN1	1	CSNK1D	3	affinity chromatography technology	Hein MY (2015)	1
KIAA0753	1	CEP44	2	bioid	Gupta GD (2015)	1
WWOX	3	SMAD3	1	pull down, affinity chromatography technology	Ferguson BW (2013), Ferguson BW (2013)	2
SMAD2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005)	2
WWOX	3	ATN1	2	affinity chromatography technology	Abu-Odeh M (2014)	1
ARRB1	2	DVL1	5	affinity chromatography technology	Chen W (2001)	1
CYLD	2	DVL1	5	affinity chromatography technology	Tauriello DV (2010)	1
AXIN1	1	DVL3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hocevar BA (2003), Sue Ng S (2010), Li VS (2012)	3
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
CEP19	0	DVL3	7	bioid	Gupta GD (2015)	1
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
WWOX	3	DVL2	5	affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Huttlin EL (2017)	2
CEP128	1	CTNNB1	30	bioid	Gupta GD (2015)	1
CCP110	6	DVL1	5	bioid	Gupta GD (2015)	1
NKD2	1	DVL1	5	affinity chromatography technology, biochemical	Hu T (2010), Hu T (2010)	2
USP13	2	DVL1	5	two hybrid	Stelzl U (2005)	1
XPO1	8	CYLD	2	affinity chromatography technology	Kirli K (2015)	1
ANXA7	0	DVL1	5	two hybrid	Vinayagam A (2011)	1
DVL3	7	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology	Song DH (2000), Huttlin EL (2017)	2
SSX2IP	0	DVL1	5	bioid	Gupta GD (2015)	1
DVL1	5	ITCH	1	affinity chromatography technology	Wei W (2012)	1
CEP128	1	DVL1	5	bioid	Gupta GD (2015)	1
CEP19	0	NCK2	2	bioid	Gupta GD (2015)	1
ATN1	2	NCK2	2	two hybrid	Lim J (2006)	1
ITCH	1	LRRK2	5	affinity chromatography technology	OConnor HF (2015)	1
SIRT1	3	DVL1	5	affinity chromatography technology	Holloway KR (2010)	1
DVL1	5	SIPA1	5	two hybrid	Wang J (2011)	1
SMAD4	9	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016)	6
FRAT1	0	PSMA3	1	two hybrid	Wang J (2011)	1
XPO1	8	SMAD1	0	affinity chromatography technology	Kirli K (2015)	1
SIRT1	3	DVL2	5	affinity chromatography technology, affinity chromatography technology	Holloway KR (2010), Holloway KR (2010)	2
CEP44	2	SIRT1	3	bioid	Gupta GD (2015)	1
XPO1	8	CTNNB1	30	affinity chromatography technology	Kirli K (2015)	1
BTRC	1	CEP44	2	affinity chromatography technology	Loveless TB (2015)	1
TMEM17	0	DVL1	5	bioid	Gupta GD (2015)	1
XPO1	8	AXIN1	1	affinity chromatography technology	Kirli K (2015)	1
DVL1	5	NCK2	2	two hybrid	Rolland T (2014)	1
ITCH	1	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down	Ahmed N (2011), Ahmed N (2011), Ahmed N (2011)	3
BTRC	1	PSMA3	1	two hybrid	Wang J (2011)	1
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
RASSF10	2	DVL3	7	affinity chromatography technology	Hauri S (2013)	1
XPO1	8	DVL1	5	affinity chromatography technology	Kirli K (2015)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
ATN1	2	DVL2	5	two hybrid	Lim J (2006)	1
CSNK1E	0	DVL1	5	affinity chromatography technology	Gao ZH (2002)	1
XPO1	8	DVL3	7	affinity chromatography technology	Kirli K (2015)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
SSX2IP	0	KIAA0753	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
DVL1	5	FLNC	8	affinity chromatography technology	Huttlin EL (2015)	1
AXIN1	1	CSNK1E	0	genetic interference, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang Y (2002), Zhang Y (2002), Wang J (2011), Hein MY (2015)	4
DVL1	5	HUWE1	22	affinity chromatography technology	de Groot RE (2014)	1
CSNK1D	3	DVL1	5	affinity chromatography technology	Gao ZH (2002)	1
WWP2	7	SMAD7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Soond SM (2011), Al-Salihi MA (2012)	4
CEP135	2	DVL2	5	bioid	Gupta GD (2015)	1
ARRB1	2	NEDD4	2	affinity chromatography technology	Shenoy SK (2008)	1
AHI1	4	SSX2IP	0	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
DVL1	5	DVL1	5	affinity chromatography technology	Kishida S (1999)	1
CSNK1E	0	KIAA0753	1	affinity chromatography technology	Hein MY (2015)	1
ARRB1	2	DVL2	5	two hybrid, affinity chromatography technology	Chen W (2001), Chen W (2001)	2
WWP2	7	DVL1	5	affinity chromatography technology	Chaudhary N (2014)	1
WWP2	7	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Brown KA (2008)	3
LRRK2	5	DVL2	5	two hybrid, affinity chromatography technology	Sancho RM (2009), Sancho RM (2009)	2
SMAD3	1	DAB2	1	pull down, affinity chromatography technology	Hocevar BA (2001), Hocevar BA (2001)	2
CEP135	2	CCP110	6	bioid	Gupta GD (2015)	1
CEP128	1	DVL2	5	bioid	Gupta GD (2015)	1
BTRC	1	SMAD4	9	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wan M (2004), Wan M (2004), Yang L (2006), Yang L (2006), Wan M (2005), Liang M (2004), Demagny H (2014), Li D (2015)	8
SIRT1	3	SMAD7	1	affinity chromatography technology, affinity chromatography technology, pull down	Kume S (2007), Kume S (2007), Kume S (2007)	3
CEP135	2	CEP44	2	bioid	Gupta GD (2015)	1
HECW1	3	DVL1	5	two hybrid, affinity chromatography technology	Miyazaki K (2004), Miyazaki K (2004)	2
CEP135	2	DVL1	5	bioid	Gupta GD (2015)	1
CEP83	2	DVL1	5	bioid	Gupta GD (2015)	1
DVL3	7	HUWE1	22	affinity chromatography technology	de Groot RE (2014)	1
USP13	2	ITCH	1	affinity chromatography technology	Sowa ME (2009)	1
BTRC	1	WWTR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu CY (2011), Liu CY (2011), Varelas X (2010), Huttlin EL (2015), Loveless TB (2015), Coyaud E (2015), Lv XB (2015), Gu JJ (2016), Huttlin EL (2017)	9
AXIN1	1	NCK2	2	affinity chromatography technology	Cowan CA (2001)	1
DVL3	7	ITCH	1	affinity chromatography technology	Wei W (2012)	1
DVL2	5	WWTR1	1	affinity chromatography technology, affinity chromatography technology	Varelas X (2010), Varelas X (2010)	2
EPS8	1	DVL1	5	two hybrid, pull down, affinity chromatography technology	Inobe M (1999), Inobe M (1999), Inobe M (1999)	3
HUWE1	22	PSMA3	1	affinity chromatography technology	Thompson JW (2014)	1
FRAT1	0	DVL1	5	affinity chromatography technology	Li L (1999)	1
ATN1	2	DVL1	5	two hybrid	Okamura-Oho Y (1999)	1
XPO1	8	CSNK1D	3	affinity chromatography technology	Kirli K (2015)	1
LRRK2	5	DVL1	5	two hybrid, affinity chromatography technology	Sancho RM (2009), Sancho RM (2009)	2
WWP2	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid	Soond SM (2011), Soond SM (2011), Soond SM (2011), Brown KA (2008), Soond SM (2013), Yu H (2011)	6
CYLD	2	SDC4	0	affinity chromatography technology	Lin W (2016)	1
CEP128	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
RASSF9	0	DVL1	5	affinity chromatography technology	Hauri S (2013)	1
BTRC	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
NUMA1	10	DVL3	7	affinity chromatography technology	Yang Y (2014)	1
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
NUMA1	10	DVL2	5	affinity chromatography technology	Yang Y (2014)	1
DVL2	5	CTNNB1	30	affinity chromatography technology	Song DH (2000)	1
HUWE1	22	WWOX	3	affinity chromatography technology	Thompson JW (2014)	1
DCTN1	6	AHI1	4	affinity chromatography technology	Boldt K (2016)	1
DVL2	5	WWP2	7	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Mund T (2015), Mund T (2015), Mund T (2015), Mund T (2015), Chaudhary N (2014)	5
XPO1	8	DAB2	1	affinity chromatography technology	Kirli K (2015)	1
BTRC	1	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Kitagawa M (1999), Kitagawa M (1999), Li VS (2012), Coyaud E (2015), Coyaud E (2015), Novellasdemunt L (2017)	6
DVL3	7	WWTR1	1	affinity chromatography technology	Varelas X (2010)	1
DAB2	1	DVL2	5	pull down, affinity chromatography technology	Hocevar BA (2003), Hocevar BA (2003)	2
KIAA0753	1	CCP110	6	bioid	Firat-Karalar EN (2014)	1
CEP44	2	NCK2	2	bioid	Gupta GD (2015)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP19	0	DVL2	5	bioid	Gupta GD (2015)	1
BTRC	1	SSX2IP	0	bioid	Coyaud E (2015)	1
CEP128	1	CEP44	2	bioid	Gupta GD (2015)	1
DVL1	5	NEDD4	2	pull down	Nethe M (2012)	1
DVL1	5	WWTR1	1	affinity chromatography technology	Varelas X (2010)	1
ATN1	2	PSMA3	1	two hybrid	Lim J (2006)	1
SMAD2	5	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Xi Y (2013)	3
SMAD4	9	CTNNB1	30	affinity chromatography technology	Tian YC (2002)	1
DVL2	5	CSNK2A1	15	affinity chromatography technology	Song DH (2000)	1
WWOX	3	DVL1	5	affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014)	2
RASSF10	2	DVL2	5	affinity chromatography technology	Hauri S (2013)	1
RASSF9	0	DVL2	5	affinity chromatography technology	Hauri S (2013)	1
DCTN1	6	FLNC	8	biochemical	Havugimana PC (2012)	1
XPO1	8	DVL2	5	affinity chromatography technology	Kirli K (2015)	1
HUWE1	22	XPO1	8	affinity chromatography technology	Thompson JW (2014)	1
SMAD1	0	DVL1	5	pull down	Warner DR (2003)	1
KIAA0753	1	DVL1	5	bioid	Gupta GD (2015)	1
CEP135	2	SSX2IP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
DVL3	7	CYLD	2	affinity chromatography technology	Tauriello DV (2010)	1
DAB2	1	AXIN1	1	pull down	Hocevar BA (2003)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
SSX2IP	0	DVL3	7	bioid	Gupta GD (2015)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
CEP19	0	DVL1	5	bioid	Gupta GD (2015)	1
DVL1	5	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Li L (1999), Kim MJ (2008)	2
WWOX	3	DVL3	7	affinity chromatography technology	Abu-Odeh M (2014)	1
LRRK2	5	DVL3	7	two hybrid, affinity chromatography technology	Sancho RM (2009), Sancho RM (2009)	2
CYLD	2	PSMA3	1	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	DCTN1	6	affinity chromatography technology	Elliott PR (2016)	1
RASSF9	0	DVL3	7	affinity chromatography technology	Hauri S (2013)	1
SMAD7	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005), Al-Salihi MA (2012)	3
CETN2	0	DVL1	5	bioid	Gupta GD (2015)	1
ITCH	1	SMAD2	5	enzymatic study, affinity chromatography technology	Bai Y (2004), Bai Y (2004)	2
CEP128	1	CCP110	6	bioid	Gupta GD (2015)	1
BTRC	1	DVL1	5	bioid	Coyaud E (2015)	1
CTNNB1	30	AXIN1	1	pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hocevar BA (2003), Hino S (2005), Stoothoff WH (2002), Kim MJ (2008), Kitagawa M (1999), Kitagawa M (1999), Arnold HK (2009), Zhang YG (2012), Godin JD (2010), Godin JD (2010), Sue Ng S (2010), Sue Ng S (2010), Tang Y (2008), Li VS (2012), Yamamoto H (2006), Fei C (2013), Hein MY (2015), Kuslansky Y (2016), Novellasdemunt L (2017)	25
NEDD4	2	CSNK1D	3	affinity chromatography technology	Liu J (2014)	1
SMAD1	0	NEDD4	2	affinity chromatography technology, two hybrid	Kim BG (2011), Colland F (2004)	2
DCTN1	6	CEP44	2	bioid	Gupta GD (2015)	1
CSNK1E	0	DVL3	7	two hybrid	Rolland T (2014)	1
ARRB1	2	CSNK2A1	15	affinity chromatography technology	Ewing RM (2007)	1
CEP44	2	DVL3	7	bioid	Gupta GD (2015)	1
SSX2IP	0	DVL2	5	bioid	Gupta GD (2015)	1
DAB2	1	DVL1	5	pull down	Hocevar BA (2003)	1
HUWE1	22	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Thompson JW (2014), Dominguez-Brauer C (2017), Dominguez-Brauer C (2017), Dominguez-Brauer C (2017)	4
SMAD7	1	DVL1	5	pull down	Warner DR (2003)	1
ARRB1	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Bhandari D (2007)	2
DVL1	5	DVL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2015), Huttlin EL (2017)	3
CSNK1E	0	CSNK1D	3	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
XPO1	8	CCP110	6	affinity chromatography technology	Kirli K (2015)	1
SMAD3	1	DVL1	5	pull down	Warner DR (2003)	1
CSNK2A1	15	PSMA3	1	enzymatic study	Zhang M (2011)	1
CEP128	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
WWOX	3	CSNK2A1	15	affinity chromatography technology	Abu-Odeh M (2014)	1
NUMA1	10	DVL1	5	affinity chromatography technology	Yang Y (2014)	1
DVL2	5	DVL3	7	affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2017)	2
DVL1	5	CSNK2A1	15	affinity chromatography technology, imaging technique	Song DH (2000), Chen TC (2014)	2
KIAA0753	1	DVL2	5	bioid	Firat-Karalar EN (2014)	1
DCTN1	6	DVL1	5	bioid	Gupta GD (2015)	1
RASSF10	2	DVL1	5	affinity chromatography technology	Hauri S (2013)	1
ARRB1	2	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Rosano L (2009)	2
ITCH	1	SMAD3	1	pull down	Feng L (2004)	1
XPO1	8	SSX2IP	0	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	CSNK2A1	15	affinity chromatography technology	Kirli K (2015)	1
SMAD4	9	DVL1	5	pull down	Warner DR (2003)	1
USP13	2	CYLD	2	affinity chromatography technology	Sowa ME (2009)	1
ATN1	2	ITCH	1	two hybrid, pull down	Wood JD (1998), Wood JD (1998)	2
WWOX	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014), Abu-Odeh M (2014)	3
SMAD3	1	CSNK1D	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Brown KA (2008), Ding L (2009), Ding L (2009)	3
CEP135	2	CYLD	2	bioid	Gupta GD (2015)	1
XPO1	8	SMAD4	9	affinity chromatography technology	Kirli K (2015)	1
CSNK2A1	15	ITCH	1	enzymatic study	Morales B (2007)	1
SMAD7	1	AXIN1	1	affinity chromatography technology	Tang Y (2008)	1
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
CYLD	2	FLNC	8	affinity chromatography technology	Elliott PR (2016)	1
SMAD3	1	NEDD4	2	affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Kuratomi G (2005), Persaud A (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011)	6
CEP128	1	CSNK1D	3	bioid	Gupta GD (2015)	1
DVL3	7	CTNNB1	30	affinity chromatography technology	Song DH (2000)	1