PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CAV1	0	GRK2	4	pull down	Carman CV (1999)	1
AGTR1	4	ATP2B3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGTR1	4	RAF1	3	affinity chromatography technology	Luttrell LM (2001)	1
PTGFR	1	ATP12A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK1	1	ARRB1	2	enzymatic study	Lin FT (1999)	1
CAV1	0	MAPK1	1	affinity chromatography technology	Hua H (2003)	1
PTGS2	0	AGTR1	4	affinity chromatography technology, affinity chromatography technology	Sood R (2014), Sood R (2014)	2
AGTR1	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGTR1	4	SLC19A2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGTR1	4	ARRB1	2	affinity chromatography technology	Barnes WG (2005)	1
MAPK1	1	RAF1	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Dougherty MK (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Wang J (2009), Wang J (2009)	7
AGTR1	4	THOC7	0	affinity chromatography technology	Huttlin EL (2015)	1
CAV1	0	GRK5	7	pull down	Carman CV (1999)	1
RAF1	3	JAK2	1	pull down	Xia K (1996)	1
AGTR1	4	ATP12A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGTR1	4	JAK2	1	affinity chromatography technology	Sayeski PP (2001)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
AGTR1	4	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
AGTR1	4	BDKRB2	0	biochemical	AbdAlla S (2000)	1
AGTR1	4	SLC6A8	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGTR1	4	ATP2B4	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRK2	4	ARRB1	2	affinity chromatography technology	Nogues L (2011)	1
AGTR1	4	MAPK1	1	affinity chromatography technology	Luttrell LM (2001)	1
RAB5A	0	AGTR1	4	pull down	Seachrist JL (2002)	1
AGTR1	4	RACK1	2	affinity chromatography technology	Parent A (2008)	1
PTGS2	0	CAV1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Liou JY (2001), Liou JY (2001), Liou JY (2001), Chen SF (2010), Liou JY (2001), Liou JY (2001), Chen SF (2013), Chen SF (2013), Chen SF (2013)	9
AGTR1	4	ALG10	0	affinity chromatography technology	Huttlin EL (2015)	1
AGTR1	4	ARRB2	5	affinity chromatography technology, affinity chromatography technology	Luttrell LM (2001), Barnes WG (2005)	2
AGTR1	4	PIGU	0	affinity chromatography technology	Huttlin EL (2015)	1
HTR2B	4	AGTR1	4	affinity chromatography technology	Jaffre F (2009)	1
AGTR1	4	C1orf112	0	affinity chromatography technology	Huttlin EL (2015)	1
PTGFR	1	AGTR1	4	affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, fluorescent resonance energy transfe	Goupil E (2015), Goupil E (2015), Goupil E (2015), Goupil E (2015), Goupil E (2015)	5
AGTR1	4	SETD7	2	affinity chromatography technology	Huttlin EL (2015)	1
AGTR1	4	CLCC1	4	affinity chromatography technology	Huttlin EL (2015)	1
AGTR1	4	PDE6H	0	two hybrid	Rolland T (2014)	1
AGTR1	4	VKORC1L1	1	affinity chromatography technology	Huttlin EL (2015)	1
ARRB2	5	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Shenoy SK (2005), Luttrell LM (2001), Xiao K (2007), Chen TC (2014)	4
RACK1	2	AGTRAP	1	pull down, affinity chromatography technology, two hybrid	Wang W (2002), Wang W (2002), Wang W (2002)	3
PTGFR	1	ATP2B3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGTR1	4	AGTRAP	1	pull down	Wang W (2002)	1
CLCC1	4	TSPAN15	0	affinity chromatography technology	Huttlin EL (2017)	1
AGTR1	4	GRK2	4	affinity chromatography technology	Freedman NJ (1997)	1
ARRB2	5	RAF1	3	affinity chromatography technology	Luttrell LM (2001)	1
AGTR1	4	TMEM11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGTR1	4	GRK5	7	affinity chromatography technology	Freedman NJ (1997)	1
AGTR1	4	TSPAN15	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2