PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D4	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
MAP3K1	4	NOTCH1	25	enzymatic study, affinity chromatography technology	Ahn JS (2016), Ahn JS (2016)	2
GRB2	2	EP300	36	two hybrid	Bandyopadhyay S (2010)	1
UBE2D4	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
EGR2	1	DTX1	2	affinity chromatography technology	Hsiao HW (2009)	1
DTX1	2	DTX1	2	affinity chromatography technology	Yamamoto N (2001)	1
EP300	36	UBE2D1	0	pull down, pull down	Shi D (2009), Grossman SR (2003)	2
ITCH	1	NOTCH1	25	affinity chromatography technology	Puca L (2013)	1
UBE2D1	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
NOTCH1	25	DTX1	2	affinity chromatography technology, affinity chromatography technology	Yamamoto N (2001), Zhang P (2010)	2
UBE2D1	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
UBE2D3	1	UBE2C	1	biochemical	Wan C (2015)	1
TAX1BP3	1	DTX1	2	two hybrid, fluorescent resonance energy transfe	Zencir S (2013), Zencir S (2013)	2
UBE2D2	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
G3BP1	4	EIF3F	1	affinity chromatography technology	Jain S (2016)	1
EIF3F	1	DTX1	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Moretti J (2010), Moretti J (2010), Moretti J (2010)	3
TAX1BP3	1	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
GRB2	2	MAP3K1	4	pull down, affinity chromatography technology, affinity chromatography technology	Pomerance M (1998), Pomerance M (1998), Saito T (2004)	3
UBE2N	1	DTX1	2	two hybrid	van Wijk SJ (2009)	1
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
EIF3F	1	NOTCH1	25	affinity chromatography technology, imaging technique	Moretti J (2010), Moretti J (2010)	2
DTX3L	1	ITCH	1	affinity chromatography technology, pull down, pull down	Holleman J (2014), Holleman J (2014), Holleman J (2014)	3
UBE2C	1	DTX1	2	two hybrid	van Wijk SJ (2009)	1
UBE2D4	0	DTX3L	1	two hybrid	Markson G (2009)	1
UBE2E1	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
EP300	36	DTX1	2	affinity chromatography technology, two hybrid	Yamamoto N (2001), Yamamoto N (2001)	2
DTX3L	1	UBE2D3	1	affinity chromatography technology, two hybrid	Takeyama K (2003), Markson G (2009)	2
DTX1	2	GRB2	2	two hybrid	Matsuno K (1998)	1
UBE2D3	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
DTX1	2	DTX3L	1	affinity chromatography technology	Takeyama K (2003)	1
UBE2D3	1	DTX1	2	two hybrid	van Wijk SJ (2009)	1
DTX3L	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down	Takeyama K (2003), Markson G (2009), Yan Q (2009)	3
DTX3L	1	UBE2D2	0	affinity chromatography technology, two hybrid, pull down	Takeyama K (2003), Markson G (2009), Yan Q (2009)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
ITCH	1	GRB2	2	biochemical	Wan C (2015)	1
UBE2E1	1	DTX1	2	two hybrid	van Wijk SJ (2009)	1
UBE2E1	1	DTX3L	1	two hybrid	Markson G (2009)	1
DTX1	2	MAP3K1	4	affinity chromatography technology, pull down	Liu WH (2005), Liu WH (2005)	2
EP300	36	NOTCH1	25	affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Hao L (2010), Popko-Scibor AE (2011), Popko-Scibor AE (2011), Popko-Scibor AE (2011)	4
DEFA5	1	DTX1	2	two hybrid	Wang J (2011)	1
UBE2D2	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
ITCH	1	UBE2E1	1	pull down, pull down	Bai Y (2004), Ahn YH (2009)	2
G3BP1	4	DTX3L	1	affinity chromatography technology	Jain S (2016)	1
DTX1	2	G3BP1	4	two hybrid	Wang J (2011)	1
ITCH	1	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
ITCH	1	DTX1	2	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Chastagner P (2008), Chastagner P (2006), Chastagner P (2006), Chastagner P (2006)	4