Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
AGT 183 HYDROCHLOROTHIAZIDE CHEMBL435 PharmGKB
AGT 183 QUINAPRIL CHEMBL1592 NCI 11849656, 12693379
AGT 183 SPARSENTAN CHEMBL539423 DrugBank
AGT 183 ENALAPRIL CHEMBL578 NCI 11928713
AGT 183 MESTRANOL CHEMBL1201151 NCI 3023023
AGT 183 CYCLOSPORINE CHEMBL160 NCI 10642325
AGT 183 HYDROCORTISONE CHEMBL389621 NCI 15576665

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
AGT rs699 A losartan efficacy no This SNP was presented as AGT M235T. No differences in systemic hemodynamics was seen between genotype groups. Allele A is not associated with increased response to losartan in people with Liver Cirrhosis as compared to allele G. 15743363 1144788614
AGT rs699 GG irbesartan efficacy yes Patients with the GG genotype had a greater change in left ventricular mass between baseline and after 12 weeks of treatment, compared to other genotypes. Please note alleles have been complemented to the plus chromosomal strand. Genotype GG is associated with increased response to irbesartan in people with Hypertrophy, Left Ventricular as compared to genotypes AA + AG. 15614026 982036621
AGT rs699 G Antihypertensives efficacy not stated Patients were treated with atenolol, lisinopril, nifedipine. Allele G is not associated with response to Antihypertensives in people with Hypertension. 8728305 769170906
AGT rs7079 GG benazepril efficacy yes Only when rs2640543 genotype (AGTR1 gene) is also taken into account (gene-gene interaction model). Please see study for analysis details - the genotype conferring increased likelihood of response/ sensitivity was not clear. Please note, this study reported alleles C>A - here we have represented the complementary alleles on the plus strand (G>T). Genotype GG is associated with response to benazepril in women with Hypertension as compared to genotype TT. 21449848 827807029
AGT rs4762 A losartan efficacy no This SNP was presented as AGT T174M. No differences in systemic hemodynamics was seen between genotype groups. Allele A is not associated with increased response to losartan in people with Liver Cirrhosis as compared to allele G. 15743363 1144910963
AGT rs5050 GG irbesartan efficacy no No differences in the change in systolic blood pressure (SBP) or diastolic blood pressure (DBP) was seen between genotypes, between baseline and 12 weeks of treatment. ANOVA was used, so p-value refers to associations when comparing all three genotypes against each other. Please note alleles have been complemented to the plus chromosomal strand. Genotype GG is not associated with response to irbesartan in people with Hypertension as compared to genotypes GT + TT. 14700505 982043057
AGT rs699 GG quinapril efficacy yes This SNP was presented as AGT M253T. T homozygotes (genotype GG) had greater minimal lumen diameter, lower late lumen loss, and lower restenosis rates after percutaneous coronary intervention as compared to patients carrying the A allele, which codes for the M amino acid. Genotype GG is associated with increased response to quinapril in people with Coronary Artery Disease as compared to genotypes AA + AG. 11849656 982047936
AGT rs7079 TT benazepril efficacy yes Patients with the TT genotype had a greater decrease in diastolic blood pressure between baseline and 3 years of treatment, compared to those with the GT or GG genotypes. Genotypes were analyzed in an exploratory group (n=733), a confirmatory group (n=714) and for the total population (n=1447). A significant result for systolic blood pressure was seen in the total population. Please note alleles have been complemented to the plus chromosomal strand. Genotype TT is associated with increased response to benazepril in people with Hypertension as compared to genotypes GG + GT. 17261659 982037006
AGT rs699 AG + GG atenolol efficacy yes Carriers of the G allele had a greater decrease in systolic blood pressure between baseline and after 12 weeks of treatment, as compared to AA homozygotes. Please note alleles have been complemented to the plus chromosomal strand. Genotypes AG + GG are associated with increased response to atenolol in people with Hypertension as compared to genotype AA. 14700505 982042952
AGT rs5051 CT + TT atenolol efficacy yes No differences in the change in diastolic blood pressure was seen between genotypes, between baseline and 12 weeks of treatment. ANOVA was used, so p-value refers to associations when comparing all three genotypes against each other. Please note alleles have been complemented to the plus chromosomal strand. Genotypes CT + TT are not associated with response to atenolol in people with Hypertension as compared to genotype CC. 14700505 982042996
AGT rs699 AG + GG captopril efficacy no No significant difference in the 99mTc-MAG3 clearance (MAG3cle) values after treatment with captopril was seen between G allele carriers and AA homozygotes. MAG3cle provides an estimation of effective renal plasma flow (ERPF), and therefore of responsiveness to captopril treatment. Genotypes AG + GG are not associated with response to captopril in people with Diabetes Mellitus, Type 2 as compared to genotype AA. 19286758 982044553
AGT rs699 AG + GG atenolol efficacy no No differences in the change in diastolic blood pressure was seen between genotypes, between baseline and 12 weeks of treatment. ANOVA was used, so p-value refers to associations when comparing all three genotypes against each other. Please note alleles have been complemented to the plus chromosomal strand. Genotypes AG + GG are not associated with response to atenolol in people with Hypertension as compared to genotype AA. 14700505 982042988
AGT rs5051 CC irbesartan efficacy no No differences in the change in systolic blood pressure (SBP) or diastolic blood pressure (DBP) was seen between genotypes, between baseline and 12 weeks of treatment. ANOVA was used, so p-value refers to associations when comparing all three genotypes against each other. Please note alleles have been complemented to the plus chromosomal strand. Genotype CC is not associated with response to irbesartan in people with Hypertension as compared to genotypes CT + TT. 14700505 982043031
AGT rs699 AG atorvastatin metabolism/PK no The SNP was not associated with AUC, Cmax, clearance, elimination rate constant, or half-life of atorvastatin. However, the AG genotype was associated with higher AUC ad well as lower clearance of atorvastatin vs. AA or GG genotypes. Genotype AG is not associated with exposure to atorvastatin in healthy individuals as compared to genotypes AA + GG. 29250329 1449169556
AGT rs4762 GG benazepril efficacy yes Only when rs2106809 genotype (ACE2 gene) is also taken into account (gene-gene interaction model). Please see study for analysis details - the genotype conferring increased likelihood of response/ sensitivity was not clear. Please note, this study reported alleles C>T - here we have represented the complementary alleles on the plus strand (G>A). Genotype GG is associated with response to benazepril in men with Hypertension as compared to genotype AA. 21449848 827806987
AGT rs4762 G benazepril efficacy yes When in a haplotype with rs699 allele A and rs7079 allele T. Patients with this haplotype had a greater decrease in diastolic blood pressure between baseline and 3 years of treatment, compared to those with any other combination of alleles at these positions. Haplotypes were analyzed in an exploratory group (n=733), a confirmatory group (n=714) and for the total population (n=1447). Significant results were only seen for the confirmatory and total populations. Please note alleles have been complemented to the plus chromosomal strand. Allele G is associated with increased response to benazepril in people with Hypertension. 17261659 982037196
AGT rs4762 GG atenolol efficacy no No significant differences in the change in diastolic or systolic blood pressure after 3 months of treatment were seen between the genotypes. 43 patients were given atenolol and 43 were given irbesartan; these two drug cohorts were analyzed as separate groups. Genotype GG is not associated with response to atenolol or irbesartan in people with Hypertension as compared to genotype AG. 11593098 1183615160
AGT rs5050 GG atenolol efficacy no No differences in the change in systolic blood pressure (SBP) or diastolic blood pressure (DBP) was seen between genotypes, between baseline and 12 weeks of treatment. ANOVA was used, so p-value refers to associations when comparing all three genotypes against each other. Please note alleles have been complemented to the plus chromosomal strand. Genotype GG is not associated with response to atenolol in people with Hypertension as compared to genotypes GT + TT. 14700505 982042973
AGT rs5051 CT + TT atenolol efficacy yes Carriers of the A allele had a greater decrease in systolic blood pressure between baseline and after 12 weeks of treatment, as compared to CC homozygotes. Please note alleles have been complemented to the plus chromosomal strand. Genotypes CT + TT are associated with increased response to atenolol in people with Hypertension as compared to genotype CC. 14700505 982042944
AGT rs5051 CC benazepril efficacy yes Those with the CC genotype had significantly greater reductions in systolic blood pressure (p=0.04), diastolic blood pressure (p=0.014), pulse pressure (p=0.019) and mean arterial pressure (p<0.001) after six weeks of treatment, as compared to those with the CT or TT genotypes. rs5051 genotype was found to be a significant predictor of all the phenotypes listed above (the p-values quoted above refer to this analysis). Please note alleles have been complemented to the plus chromosomal strand. Genotype CC is associated with increased response to benazepril or imidapril in people with Hypertension as compared to genotypes CT + TT. 25143324 1296598578
AGT rs7079 T benazepril efficacy yes When in a haplotype with rs4762 allele G and rs699 allele A. Patients with this haplotype had a greater decrease in diastolic blood pressure between baseline and 3 years of treatment, compared to those with any other combination of alleles at these positions. Haplotypes were analyzed in an exploratory group (n=733), a confirmatory group (n=714) and for the total population (n=1447). Significant results were only seen for the confirmatory and total populations. Please note alleles have been complemented to the plus chromosomal strand. Allele T is associated with increased response to benazepril in people with Hypertension. 17261659 982037219
AGT rs699 A benazepril efficacy yes When in a haplotype with rs4762 allele G and rs7079 allele T. Patients with this haplotype had a greater decrease in diastolic blood pressure between baseline and 3 years of treatment, compared to those with any other combination of alleles at these positions. Haplotypes were analyzed in an exploratory group (n=733), a confirmatory group (n=714) and for the total population (n=1447). Significant results were only seen for the confirmatory and total populations. Please note alleles have been complemented to the plus chromosomal strand. Allele A is associated with increased response to benazepril in people with Hypertension. 17261659 982037209
AGT rs699 GG irbesartan efficacy no Only a p-value < 0.01 was considered significant in order to account for multiple testing. No differences in the change in systolic blood pressure (SBP) or diastolic blood pressure (DBP) was seen between genotypes, between baseline and 12 weeks of treatment. ANOVA was used, so p-value refers to associations when comparing all three genotypes against each other. Please note alleles have been complemented to the plus chromosomal strand. Genotype GG is not associated with response to irbesartan in people with Hypertension as compared to genotypes AA + AG. 14700505 982043042
AGT rs699 GG atenolol efficacy no No significant differences in the change in diastolic or systolic blood pressure after 3 months of treatment were seen between the genotypes. 43 patients were given atenolol and 43 were given irbesartan; these two drug cohorts were analyzed as separate groups. Genotype GG is not associated with response to atenolol or irbesartan in people with Hypertension as compared to genotypes AA + AG. 11593098 1183615155