PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EZH2	4	DSC3	1	affinity chromatography technology	Cao Q (2014)	1
MAPK6	1	UCHL5	1	affinity chromatography technology	Rodriguez J (2016)	1
PKP4	5	DSC3	1	two hybrid	Hatzfeld M (2003)	1
CYLD	2	JUP	7	affinity chromatography technology	Elliott PR (2016)	1
RYK	1	DSC3	1	affinity chromatography technology	Berndt JD (2011)	1
DSC3	1	JUP	7	affinity chromatography technology	Hanakawa Y (2000)	1
CDH1	4	JUP	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Hazan RB (1998), Shibata T (1994), Hinck L (1994), Knudsen KA (1992), Geng F (2012), Guo Z (2014)	7
MCM2	3	JUP	7	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	DSC3	1	affinity chromatography technology	Drissi R (2015)	1
CYLD	2	DSC3	1	affinity chromatography technology	Elliott PR (2016)	1
CTNNB1	30	JUP	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hazan RB (1998), Kucerova D (2001), Hein MY (2015), Chen TC (2014)	4
MAPK6	1	DSC3	1	affinity chromatography technology	Rodriguez J (2016)	1
PTPRD	6	DSC3	1	bioid	St-Denis N (2016)	1
UCHL5	1	DSC3	1	pull down	Fang Y (2011)	1
CDH1	4	PKP3	4	bioid	Guo Z (2014)	1
EZH2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2009), Li X (2009), Shi B (2007), Shi B (2007), Shi B (2007)	5
CDH1	4	DSC3	1	bioid	Guo Z (2014)	1
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
PKP3	4	JUP	7	two hybrid	Bonne S (2003)	1
MAPK6	1	CTNNB1	30	affinity chromatography technology	Rodriguez J (2016)	1
DSC3	1	CTNNB1	30	affinity chromatography technology	Hanakawa Y (2000)	1
RYK	1	CTNNB1	30	affinity chromatography technology	Berndt JD (2011)	1
PKP4	5	CDH1	4	two hybrid, bioid	Hatzfeld M (2003), Guo Z (2014)	2
TMEM30B	0	DSC3	1	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	PKP4	5	affinity chromatography technology	Drissi R (2015)	1
PKP3	4	DSC3	1	two hybrid, affinity chromatography technology	Bonne S (2003), Bonne S (2003)	2
MCM2	3	CTNNB1	30	affinity chromatography technology	Drissi R (2015)	1