Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
DRD4 1815 BENPERIDOL CHEMBL297302 antagonist GuideToPharmacologyInteractions
DRD4 1815 RISPERIDONE CHEMBL85 antagonist DrugBank 7531353, 7520908
DRD4 1815 HALOPERIDOL CHEMBL54 antagonist, inverse agonist GuideToPharmacologyInteractions, ChemblInteractions
DRD4 1815 PEROSPIRONE CHEMBL1472975 antagonist GuideToPharmacologyInteractions
DRD4 1815 SONEPIPRAZOLE CHEMBL69759 antagonist, binder GuideToPharmacologyInteractions, TTD
DRD4 1815 SULPIRIDE CHEMBL26 antagonist GuideToPharmacologyInteractions
DRD4 1815 TERGURIDE CHEMBL73151 antagonist GuideToPharmacologyInteractions
DRD4 1815 CHEMBL64119 CHEMBL64119 antagonist GuideToPharmacologyInteractions
DRD4 1815 LEVOMEPROMAZINE CHEMBL1764 antagonist ChemblInteractions, DrugBank 15701205
DRD4 1815 CHLORPROMAZINE HYDROCHLORIDE CHEMBL1713 antagonist ChemblInteractions
DRD4 1815 OLANZAPINE PAMOATE CHEMBL1201741 antagonist ChemblInteractions
DRD4 1815 THIORIDAZINE HYDROCHLORIDE CHEMBL1200916 antagonist ChemblInteractions
DRD4 1815 DROPERIDOL CHEMBL1108 antagonist ChemblInteractions
DRD4 1815 BELAPERIDONE CHEMBL2105926 antagonist TTD
DRD4 1815 PRAMIPEXOLE CHEMBL301265 TdgClinicalTrial, TEND
DRD4 1815 CHEMBL332154 CHEMBL332154 antagonist TTD
DRD4 1815 ZICRONAPINE CHEMBL3039528 TdgClinicalTrial
DRD4 1815 PERGOLIDE MESYLATE CHEMBL1275 agonist ChemblInteractions
DRD4 1815 ETILEVODOPA CHEMBL1823681 TdgClinicalTrial
DRD4 1815 MELEVODOPA CHEMBL1328898 TdgClinicalTrial
DRD4 1815 ERGOLOID MESYLATES CHEMBL2311030 agonist ChemblInteractions
DRD4 1815 CLOZAPINE CHEMBL42 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 15886414, 11752352, 15992586, 16223700, 13129658, 12763097
DRD4 1815 AMOXAPINE CHEMBL1113 antagonist ChemblInteractions, DrugBank 16135699
DRD4 1815 APOMORPHINE CHEMBL53 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 18691132, 17164075, 11752352, 17067298, 9497025, 9871530, 15007532
DRD4 1815 THIETHYLPERAZINE CHEMBL1378 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
DRD4 1815 PROMAZINE CHEMBL564 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
DRD4 1815 ROTIGOTINE CHEMBL1303 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 18691132
DRD4 1815 FENOLDOPAM CHEMBL588 agonist GuideToPharmacologyInteractions
DRD4 1815 CHEMBL1255588 CHEMBL1255588 antagonist GuideToPharmacologyInteractions
DRD4 1815 CHEMBL444309 CHEMBL444309 antagonist GuideToPharmacologyInteractions
DRD4 1815 PIRIBEDIL (CHEMBL1371770) CHEMBL1371770 antagonist GuideToPharmacologyInteractions
DRD4 1815 SPIPERONE CHEMBL267930 antagonist GuideToPharmacologyInteractions
DRD4 1815 TRIFLUOPERAZINE CHEMBL422 antagonist GuideToPharmacologyInteractions
DRD4 1815 PALIPERIDONE CHEMBL1621 antagonist DrugBank 7531353, 7520908
DRD4 1815 ZIPRASIDONE CHEMBL708 TEND
DRD4 1815 DEXPRAMIPEXOLE CHEMBL249420 TdgClinicalTrial
DRD4 1815 SARIZOTAN CHEMBL220808 agonist TTD
DRD4 1815 ASENAPINE (CHEMBL3187365) CHEMBL3187365 TdgClinicalTrial
DRD4 1815 PIMOZIDE CHEMBL1423 antagonist ChemblInteractions
DRD4 1815 HALOPERIDOL LACTATE CHEMBL2096643 inverse agonist ChemblInteractions
DRD4 1815 LOXAPINE HYDROCHLORIDE CHEMBL1201060 antagonist ChemblInteractions
DRD4 1815 SARIZOTAN HYDROCHLORIDE CHEMBL2146110 agonist ChemblInteractions
DRD4 1815 ROXINDOLE CHEMBL431367 agonist GuideToPharmacologyInteractions
DRD4 1815 ARIPIPRAZOLE CHEMBL1112 partial agonist, antagonist DrugBank 17848919
DRD4 1815 ROPINIROLE CHEMBL589 agonist TdgClinicalTrial, DrugBank 11752352, 18691132
DRD4 1815 CHEMBL219182 CHEMBL219182 agonist GuideToPharmacologyInteractions
DRD4 1815 DOPAMINE CHEMBL59 agonist GuideToPharmacologyInteractions
DRD4 1815 ETICLOPRIDE CHEMBL8946 antagonist GuideToPharmacologyInteractions
DRD4 1815 CHEMBL25918 CHEMBL25918 antagonist GuideToPharmacologyInteractions
DRD4 1815 SERTINDOLE CHEMBL12713 antagonist GuideToPharmacologyInteractions
DRD4 1815 CHEMBL103772 CHEMBL103772 antagonist GuideToPharmacologyInteractions, TTD
DRD4 1815 ZOTEPINE CHEMBL285802 antagonist GuideToPharmacologyInteractions
DRD4 1815 FLIBANSERIN CHEMBL231068 antagonist DrugBank 12890707, 12177684, 26412054
DRD4 1815 PARDOPRUNOX HYDROCHLORIDE CHEMBL2105649 DrugBank
DRD4 1815 BROMOCRIPTINE MESYLATE CHEMBL1200503 agonist ChemblInteractions
DRD4 1815 PROMAZINE HYDROCHLORIDE CHEMBL1200469 antagonist ChemblInteractions
DRD4 1815 THIORIDAZINE CHEMBL479 antagonist ChemblInteractions
DRD4 1815 APOMORPHINE HYDROCHLORIDE CHEMBL1616 agonist ChemblInteractions
DRD4 1815 TRIFLUOPERAZINE HYDROCHLORIDE CHEMBL1710 antagonist ChemblInteractions
DRD4 1815 TIANEPTINE CHEMBL1289110 binder TTD
DRD4 1815 OLANZAPINE CHEMBL715 antagonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 11752352, 16237394
DRD4 1815 CABERGOLINE CHEMBL1201087 agonist GuideToPharmacologyInteractions, DrugBank 18691132, 12388667
DRD4 1815 LISURIDE CHEMBL157138 agonist GuideToPharmacologyInteractions, DrugBank 18691132
DRD4 1815 PERGOLIDE CHEMBL531 agonist GuideToPharmacologyInteractions
DRD4 1815 BROMOCRIPTINE CHEMBL493 antagonist GuideToPharmacologyInteractions
DRD4 1815 LOXAPINE CHEMBL831 antagonist, binder GuideToPharmacologyInteractions, ChemblInteractions, DrugBank
DRD4 1815 PROPIOMAZINE CHEMBL1201210 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
DRD4 1815 QUINPIROLE CHEMBL240773 agonist GuideToPharmacologyInteractions
DRD4 1815 CHLORPROMAZINE CHEMBL71 antagonist GuideToPharmacologyInteractions, ChemblInteractions
DRD4 1815 NEMONAPRIDE CHEMBL20734 antagonist GuideToPharmacologyInteractions
DRD4 1815 PROCHLORPERAZINE CHEMBL728 antagonist GuideToPharmacologyInteractions
DRD4 1815 CHEMBL196677 CHEMBL196677 antagonist GuideToPharmacologyInteractions
DRD4 1815 PRAMIPEXOLE DIHYDROCHLORIDE CHEMBL542257 agonist ChemblInteractions
DRD4 1815 LOXAPINE SUCCINATE CHEMBL1201155 antagonist ChemblInteractions
DRD4 1815 ROPINIROLE HYDROCHLORIDE CHEMBL1200411 agonist ChemblInteractions
DRD4 1815 HALOPERIDOL DECANOATE CHEMBL1200986 inverse agonist ChemblInteractions
DRD4 1815 PALBOCICLIB CHEMBL189963 antagonist TTD
DRD4 1815 PARDOPRUNOX CHEMBL2103832 TdgClinicalTrial
DRD4 1815 REMOXIPRIDE CHEMBL22242 antagonist DrugBank 9015795
DRD4 1815 LEVODOPA CHEMBL1009 agonist TdgClinicalTrial, DrugBank 11978145, 18549347, 9633680
DRD4 1815 ILOPERIDONE CHEMBL14376 antagonist DrugBank 23272794

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
DRD4 rs3758653 C methylphenidate efficacy no Clinical Global Impression-Severity (CGI-S) scale and the Children’s Global Assessment Scale (CGAS). Allele C is not associated with response to methylphenidate in children with Attention Deficit Disorder with Hyperactivity as compared to allele T. 28871191 1450376632
DRD4 rs11246226 AA methylphenidate efficacy yes Positive response defined as Clinical Global Impression-Improvement (CGI-I) rating of 'much improved' or 'very much improved', and decrease in Aberrant Behavior Checklist-Hyperactivity subscale of >25% from baseline. This result was not significant when considering correction for multiple testing (p<0.002). Genotype AA is associated with increased response to methylphenidate in children with Autism Spectrum Disorder as compared to genotypes AC + CC. 23856854 1184510524