PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRB2	2	DRD3	2	pull down	Oldenhof J (2001)	1
DRD3	2	CLIC6	2	two hybrid, pull down	Griffon N (2003), Griffon N (2003)	2
DRD3	2	SLC9A3	10	affinity chromatography technology, affinity chromatography technology	Armando I (2014), Armando I (2014)	2
USP48	3	SLC9A3	10	affinity chromatography technology	Armando I (2014)	1
GRB2	2	FLNA	10	affinity chromatography technology	Bisson N (2011)	1
DRD3	2	USP48	3	two hybrid, affinity chromatography technology	Armando I (2014), Armando I (2014)	2
FLNA	10	DRD3	2	two hybrid	Li M (2002)	1
DRD3	2	MPDZ	6	two hybrid	Griffon N (2003)	1
DRD3	2	EPB41L1	4	pull down, affinity chromatography technology, two hybrid	Binda AV (2002), Binda AV (2002), Binda AV (2002)	3
DRD3	2	GIPC1	1	two hybrid	Griffon N (2003)	1
DRD3	2	RDX	1	two hybrid	Griffon N (2003)	1
NCS1	2	DRD3	2	affinity chromatography technology	Kabbani N (2002)	1