PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RANBP9	5	RANBP10	0	affinity chromatography technology	Boldt K (2016)	1
COPG1	5	COPG2	2	two hybrid, biochemical, affinity chromatography technology	Futatsumori M (2000), Havugimana PC (2012), Huttlin EL (2017)	3
DRD1	8	RANBP10	0	affinity chromatography technology	Rex EB (2010)	1
DNAJC14	1	DRD1	8	pull down, two hybrid	Bermak JC (2001), Bermak JC (2001)	2
DRD1	8	COPG2	2	affinity chromatography technology, pull down	Bermak JC (2002), Bermak JC (2002)	2
ADA	0	DRD1	8	imaging technique	Torvinen M (2002)	1
PRKACA	2	RANBP9	5	two hybrid	Bandyopadhyay S (2010)	1
ADORA1	2	DRD1	8	affinity chromatography technology	Gines S (2000)	1
DRD1	8	HRH3	0	fluorescent resonance energy transfe	Ferrada C (2009)	1
ADA	0	ADORA1	2	imaging technique	Torvinen M (2002)	1
DRD1	8	RANBP9	5	affinity chromatography technology	Rex EB (2010)	1
DRD1	8	COPG1	5	affinity chromatography technology, pull down	Bermak JC (2002), Bermak JC (2002)	2
PRKACA	2	DRD1	8	enzymatic study	Zamanillo D (1995)	1