PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	BCAR1	6	affinity chromatography technology	Fei T (2017)	1
NCK2	2	PTK2	2	pull down, affinity chromatography technology	Goicoechea SM (2002), Goicoechea SM (2002)	2
SRC	2	BCAR1	6	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Burnham MR (1999), Burnham MR (1999), Wei L (2002), Hsia DA (2003), Kovacic-Milivojevic B (2001), Donaldson JC (2000), Angers-Loustau A (1999), Cabodi S (2004), Modzelewska K (2006), Sawada Y (2006), Riggins RB (2006), Riggins RB (2006)	12
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
RAC1	7	DOCK1	14	pull down, biochemical, affinity chromatography technology	Kiyokawa E (1998), Wan C (2015), Feng H (2015)	3
HNRNPL	3	PTK2	2	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	FBXW11	2	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
HNRNPL	3	SRC	2	affinity chromatography technology	Fei T (2017)	1
BTRC	1	DOCK1	14	affinity chromatography technology	Coyaud E (2015)	1
GRB2	2	BCAR1	6	affinity chromatography technology, pull down, affinity chromatography technology	Wang X (2000), Angers-Loustau A (1999), Ambrogio C (2005)	3
NTRK1	1	CRKL	1	affinity chromatography technology	Emdal KB (2015)	1
NCK2	2	DOCK1	14	pull down	Tu Y (2001)	1
CRK	0	PRKACA	2	two hybrid	Grossmann A (2015)	1
CUL1	7	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
PTK2	2	DOCK1	14	affinity chromatography technology	Hsia DA (2003)	1
CRK	0	DOCK1	14	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Hsia DA (2003), Hsia DA (2003), Hsia DA (2003), Nishihara H (1999), Hasegawa H (1996), Hasegawa H (1996), Gu J (2001), Matsuda M (1996), Wu Y (2005), Wan C (2015)	10
CUL1	7	DOCK1	14	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	PTK2	2	affinity chromatography technology	Emdal KB (2015)	1
MEPCE	1	DOCK1	14	affinity chromatography technology	Jeronimo C (2007)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
HNRNPL	3	NCK2	2	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	SNW1	0	affinity chromatography technology	Emdal KB (2015)	1
MAP1LC3B	1	DOCK1	14	affinity chromatography technology	Behrends C (2010)	1
ARL4A	0	RAC1	7	imaging technique	Patel M (2011)	1
PTK2	2	SRC	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Hecker TP (2002), Angers-Loustau A (1999), Relou IA (2003), Messina S (2003), Lebrun P (1998), Ponnala S (2011), Grossmann A (2015), Chen TC (2014), Lee J (2013), Reiske HR (2000)	11
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
BCAR1	6	DOCK1	14	pull down, affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Hsia DA (2003), Hsia DA (2003)	3
NTRK1	1	CUL1	7	affinity chromatography technology	Emdal KB (2015)	1
PRKACA	2	DOCK1	14	enzymatic study	Feng H (2015)	1
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
DOCK1	14	SRC	2	affinity chromatography technology	Hsia DA (2003)	1
RAC2	0	DOCK1	14	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	PTK2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid	Sieg DJ (2000), Angers-Loustau A (1999), Hildebrand JD (1996), Messina S (2003), Arold ST (2002), Vinayagam A (2011)	6
ELMO3	4	ARL4A	0	affinity chromatography technology	Patel M (2011)	1
BTRC	1	PRKACA	2	affinity chromatography technology	Sowa ME (2009)	1
NTRK1	1	MEPCE	1	affinity chromatography technology	Emdal KB (2015)	1
CRKL	1	DOCK1	14	affinity chromatography technology	Hein MY (2015)	1
FBXW11	2	DOCK1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Low TY (2014)	3
BCAR1	6	PTK2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Salgia R (1996), Hsia DA (2003), Hildebrand JD (1996), Chellaiah MA (2001), Okabe S (2002), Wang JF (2000), Wu Y (2005), Ponnala S (2011), Cho SY (2002)	9
SNW1	0	CUL1	7	affinity chromatography technology	Lleres D (2010)	1
ELMO1	2	ARL4A	0	two hybrid, affinity chromatography technology, imaging technique	Patel M (2011), Patel M (2011), Patel M (2011)	3
RHOG	4	DOCK1	14	affinity chromatography technology	Katoh H (2003)	1
ELMO1	2	RHOG	4	two hybrid	Patel M (2011)	1
DOCK1	14	ARL4A	0	affinity chromatography technology	Patel M (2011)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
BCAR1	6	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Zhou B (2004), Di Stefano P (2004), Hsia DA (2003), Hsia DA (2003), Gu J (2001), Garton AJ (1999), Angers-Loustau A (1999), Qiu W (1998), Blaukat A (1999), Wang JF (2000), Holcomb M (2006), Wu Y (2005), Cho SY (2000), Modzelewska K (2006), Modzelewska K (2006), Brehme M (2009), Cho SY (2002), Cho SY (2002), Mielenz D (2001), Peterson ME (2008), Liu BA (2012), Larsson H (1999)	22
HNRNPL	3	DOCK1	14	affinity chromatography technology	Fei T (2017)	1
ELMO1	2	DOCK1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gumienny TL (2001), Brugnera E (2002), Makino Y (2006), Yang C (2011), Huttlin EL (2015), Patel M (2011), Lee J (2016), Huttlin EL (2017)	8
FBXW11	2	PRKACA	2	two hybrid	Wallach T (2013)	1
RAC2	0	CUL1	7	two hybrid	Senadheera D (2001)	1
NTRK1	1	ELMO1	2	affinity chromatography technology	Emdal KB (2015)	1
ELMO3	4	DOCK1	14	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	DOCK1	14	affinity chromatography technology	Emdal KB (2015)	1
SNW1	0	DOCK1	14	affinity chromatography technology	Lleres D (2010)	1
GRB2	2	DOCK1	14	pull down, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Hasegawa H (1996), Bandyopadhyay S (2010), Bisson N (2011), Huttlin EL (2017)	5
PTK2	2	CRK	0	affinity chromatography technology, pull down, two hybrid	Hsia DA (2003), Angers-Loustau A (1999), Grossmann A (2015)	3
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
BCAR1	6	CRKL	1	far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Salgia R (1996), Salgia R (1996), Astier A (1997), Peterson ME (2008), Liu BA (2012)	5
RAC1	7	PTK2	2	two hybrid	Bandyopadhyay S (2010)	1
ELMO3	4	ELMO1	2	affinity chromatography technology	Huttlin EL (2017)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2
RAC1	7	GRB2	2	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1