PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	PCNA	0	affinity chromatography technology	Bennett EJ (2010)	1
XRCC6	3	DNTT	1	affinity chromatography technology	Mahajan KN (1999)	1
DNTT	1	REL	5	two hybrid	Rolland T (2014)	1
APOA1	0	DNTT	1	affinity chromatography technology	Zhou M (2004)	1
DNTT	1	DNTTIP2	1	pull down, two hybrid	Fujita K (2003), Fujita K (2003)	2
CUL3	17	ABTB2	2	pull down, affinity chromatography technology, affinity chromatography technology	Maezawa S (2008), Maezawa S (2008), Maezawa S (2008)	3
PCNA	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ohta S (2002), Ohta S (2002), Balajee AS (2001), Nicolae CM (2014)	4
CUL3	17	PRPF19	2	affinity chromatography technology	Bennett EJ (2010)	1
DNTT	1	PCNA	0	two hybrid, pull down, biochemical	Ibe S (2001), Ibe S (2001), Ibe S (2001)	3
CUL3	17	DNTT	1	affinity chromatography technology, affinity chromatography technology	Maezawa S (2008), Maezawa S (2008)	2
DNTT	1	ABTB2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Maezawa S (2008), Maezawa S (2008), Maezawa S (2008), Maezawa S (2008), Maezawa S (2008), Maezawa S (2008)	6
DNTT	1	DNTTIP1	0	two hybrid, pull down, affinity chromatography technology, biochemical	Yamashita N (2001), Yamashita N (2001), Yamashita N (2001), Yamashita N (2001)	4
DNTT	1	PRPF19	2	affinity chromatography technology, affinity chromatography technology	Mahajan KN (2003), Mahajan KN (2003)	2