PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DGUOK	1	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FER	1	DNM2	2	biochemical	Kim L (1998)	1
DNM1	21	SNX9	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down, biochemical, affinity chromatography technology	Soulet F (2005), Soulet F (2005), Soulet F (2005), Soulet F (2005), Soulet F (2005), Soulet F (2005), Huttlin EL (2017)	7
ZBBX	2	DNM3	3	affinity chromatography technology	Huttlin EL (2017)	1
DNM1	21	IRF2BPL	5	biochemical	Kristensen AR (2012)	1
DNM1	21	BIN1	2	unspecified method	Grelle G (2006)	1
GRB2	2	DNM3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	3
ITSN1	5	PACSIN3	2	two hybrid	Wong KA (2012)	1
ARRB1	2	DNM1	21	affinity chromatography technology	Xiao K (2007)	1
DNM1	21	NCL	1	biochemical	Kristensen AR (2012)	1
PACSIN2	0	PACSIN1	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Bandyopadhyay S (2010), Rolland T (2014), Huttlin EL (2017)	8
SCN2B	1	DNM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SCN2B	1	DNM3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK5	0	DNM1	21	enzymatic study	Solomaha E (2005)	1
DNM1	21	ITSN1	5	pull down, affinity chromatography technology	Solomaha E (2005), Tsyba L (2008)	2
NTRK1	1	SNX9	1	affinity chromatography technology	Emdal KB (2015)	1
BIN1	2	DNM2	2	unspecified method	Wu T (2014)	1
DNM1	21	PTK2B	6	affinity chromatography technology, affinity chromatography technology	Bruzzaniti A (2009), Bruzzaniti A (2009)	2
DNM3	3	DNMBP	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNM2	2	DNM1	21	two hybrid	Vinayagam A (2011)	1
DNM1	21	ASB13	0	two hybrid	Stelzl U (2005)	1
SH3KBP1	1	DNM1	21	affinity chromatography technology	Havrylov S (2009)	1
PTK2B	6	GRB2	2	affinity chromatography technology, affinity chromatography technology	Blaukat A (1999), Bruzzaniti A (2009)	2
LYPD6	0	DNM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PACSIN2	0	PACSIN3	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Huttlin EL (2015), Huttlin EL (2017)	5
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
AMPH	4	ITSN1	5	affinity chromatography technology	Dergai M (2011)	1
TBC1D15	1	DNM1	21	affinity chromatography technology	Huttlin EL (2017)	1
PACSIN3	2	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
SRC	2	PTK2B	6	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Keely SJ (2000), Kumar S (1999), Dikic I (1996), Dikic I (1996), Bruzzaniti A (2009)	5
ADAM2	1	DNM1	21	affinity chromatography technology	Cottrell BA (2005)	1
NUFIP1	0	BIN1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	DNM1	21	affinity chromatography technology	Emdal KB (2015)	1
DNM1	21	SUMO1	0	two hybrid, x-ray crystallography	Mishra RK (2004), Mishra RK (2004)	2
DNM1	21	SNRPA1	1	biochemical	Kristensen AR (2012)	1
TMEM9B	0	DNM3	3	affinity chromatography technology	Huttlin EL (2017)	1
FER	1	DNM3	3	biochemical	Kim L (1998)	1
HAX1	1	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNM2	2	ITSN1	5	two hybrid, pull down, pull down	Vinayagam A (2011), Solomaha E (2005), Elhamdani A (2006)	3
NTRK1	1	DNM2	2	affinity chromatography technology	Emdal KB (2015)	1
PACSIN2	0	DNM1	21	pull down	Modregger J (2000)	1
NUFIP1	0	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
SLC39A9	1	DNM1	21	affinity chromatography technology	Huttlin EL (2017)	1
DGUOK	1	AMPH	4	affinity chromatography technology	Huttlin EL (2015)	1
UBE2I	0	SH3KBP1	1	enzymatic study	Tossidou I (2012)	1
NCK2	2	NCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNM3	3	RPE	3	biochemical	Wan C (2015)	1
DNAAF2	2	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM9B	0	DNM1	21	affinity chromatography technology	Huttlin EL (2017)	1
PIAS1	4	FANCD2	3	affinity chromatography technology	Gibbs-Seymour I (2015)	1
DYRK1A	36	AMPH	4	enzymatic study	Murakami N (2006)	1
LYPD6	0	DNM3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FANCD2	3	DNM1	21	biochemical	Kristensen AR (2012)	1
ZBBX	2	DNM1	21	affinity chromatography technology	Huttlin EL (2017)	1
DNM1	21	AMPH	4	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Micheva KD (1997), Micheva KD (1997), Micheva KD (1997), Wigge P (1997), McMahon HT (1997), Chen-Hwang MC (2002), Grabs D (1997), Solomaha E (2005), Stamenova SD (2007)	9
SCN2B	1	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IQCB1	3	DNM1	21	affinity chromatography technology	Sang L (2011)	1
NCK1	0	CLINT1	1	affinity chromatography technology	Hein MY (2015)	1
SH3GL2	1	ITSN1	5	two hybrid	Vinayagam A (2011)	1
SH3GL1	3	DNM1	21	pull down	So CW (2000)	1
DNM1	21	TBC1D2	2	biochemical	Kristensen AR (2012)	1
FANCD2	3	IRF2BPL	5	biochemical	Kristensen AR (2012)	1
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
UBASH3A	3	DNM1	21	affinity chromatography technology	Bertelsen V (2007)	1
SH3BP4	2	DNM1	21	imaging technique, affinity chromatography technology, affinity chromatography technology	Tosoni D (2005), Tosoni D (2005), Tosoni D (2005)	3
DNM1	21	RPE	3	biochemical	Wan C (2015)	1
NTRK1	1	NCL	1	affinity chromatography technology	Emdal KB (2015)	1
DNM2	2	RPE	3	biochemical	Wan C (2015)	1
NCK1	0	DNM1	21	pull down, affinity chromatography technology, affinity chromatography technology	Wunderlich L (1999), Wunderlich L (1999), Cowan CA (2001)	3
DNM2	2	SH3GL2	1	pull down	Solomaha E (2005)	1
DNM3	3	DNM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNM1	21	PIN4	0	two hybrid	Stelzl U (2005)	1
AMPH	4	BIN1	2	affinity chromatography technology, affinity chromatography technology	Wigge P (1997), Huttlin EL (2017)	2
NPM3	2	CEP126	0	two hybrid	Stelzl U (2005)	1
NTRK1	1	CDK5	0	affinity chromatography technology	Emdal KB (2015)	1
TBC1D15	1	DNM2	2	affinity chromatography technology	Huttlin EL (2017)	1
PTK2B	6	SH3KBP1	1	affinity chromatography technology	Schmidt MH (2003)	1
LYPD6	0	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DYRK1A	36	DNM1	21	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen-Hwang MC (2002), Murakami N (2009), Murakami N (2009), Murakami N (2009)	4
SNX9	1	DNM3	3	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	DNM1	21	pull down, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Miki H (1994), Miki H (1994), Sastry L (1997), Solomaha E (2005), Brehme M (2009), Bisson N (2011), Stamenova SD (2007), Huttlin EL (2017)	8
FER	1	DNM1	21	biochemical	Kim L (1998)	1
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
SH3KBP1	1	SH3GL2	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Soubeyran P (2002), Soubeyran P (2002), Soubeyran P (2002), Schmidt MH (2004), Schmidt MH (2004), Vinayagam A (2011)	6
MAP3K10	2	DNM1	21	pull down	Rasmussen RK (1998)	1
DNM1	21	SRC	2	pull down, affinity chromatography technology	Solomaha E (2005), Bruzzaniti A (2009)	2
ARRB1	2	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Rosano L (2009), Buchanan FG (2006), Buchanan FG (2006), Lee J (2013)	5
NTRK1	1	DYRK1A	36	affinity chromatography technology	Emdal KB (2015)	1
SH3GL2	1	DNM1	21	pull down, pull down, pull down	Micheva KD (1997), Micheva KD (1997), Solomaha E (2005)	3
DNM3	3	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRC	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Narita T (2005), Schroeder B (2012)	2
NTRK1	1	TBC1D15	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	IRF2BPL	5	affinity chromatography technology	Emdal KB (2015)	1
CDKAL1	2	DNM1	21	affinity chromatography technology	Huttlin EL (2017)	1
DNM1	21	NPM3	2	biochemical	Kristensen AR (2012)	1
ITSN1	5	SH3KBP1	1	affinity chromatography technology	Nikolaienko O (2009)	1
DGUOK	1	BIN1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK5	0	RPE	3	biochemical	Wan C (2015)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
SNX9	1	DNM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, biochemical, pull down, affinity chromatography technology	Lundmark R (2003), Lundmark R (2003), Lundmark R (2003), Soulet F (2005), Soulet F (2005), Soulet F (2005), Soulet F (2005), Shin N (2008), Huttlin EL (2017)	9
ZBBX	2	DNM2	2	affinity chromatography technology	Huttlin EL (2017)	1
SH3GL2	1	DYRK1A	36	affinity chromatography technology	Murakami N (2009)	1
DNM2	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schroeder B (2010), Schroeder B (2010), Havrylov S (2009), Wan C (2015)	4
NTRK1	1	FANCD2	3	affinity chromatography technology	Emdal KB (2015)	1
SH3GL2	1	DNM3	3	affinity chromatography technology	Nonis D (2008)	1
CDK5	0	AMPH	4	enzymatic study	Liang S (2007)	1
CABIN1	9	DNM1	21	affinity chromatography technology	Lai MM (2000)	1
ARRB1	2	NCL	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
NUFIP1	0	AMPH	4	affinity chromatography technology	Huttlin EL (2015)	1
DNM1	21	FNBP1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Kamioka Y (2004), Kamioka Y (2004), Kamioka Y (2004)	3
DNM1	21	UBE2I	0	two hybrid	Mishra RK (2004)	1
CDKAL1	2	DNM3	3	affinity chromatography technology	Huttlin EL (2017)	1
PACSIN3	2	DNM1	21	pull down	Modregger J (2000)	1
AMPH	4	SH3GL2	1	pull down	Micheva KD (1997)	1
DNM1	21	NCK2	2	affinity chromatography technology	Cowan CA (2001)	1
ITSN1	5	FNBP1	0	two hybrid	Wong KA (2012)	1
DNM1	21	MED31	0	two hybrid	Stelzl U (2005)	1
DNM2	2	SRC	2	pull down	Solomaha E (2005)	1
PACSIN1	0	PACSIN3	2	two hybrid, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Rolland T (2014), Huttlin EL (2017)	6
DNAAF2	2	DNM3	3	affinity chromatography technology	Huttlin EL (2015)	1
DNM2	2	GRB2	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Solomaha E (2005), Brehme M (2009), Bisson N (2011), Elhamdani A (2006), Wang J (2011), Huttlin EL (2017)	6
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
DNM1	21	PACSIN1	0	affinity chromatography technology, pull down	Kamioka Y (2004), Modregger J (2000)	2
SH3GL2	1	SH3GL1	3	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
CABIN1	9	AMPH	4	affinity chromatography technology, pull down	Lai MM (2000), Lai MM (2000)	2
NTRK1	1	CLINT1	1	affinity chromatography technology	Emdal KB (2015)	1
DNM1	21	PIAS1	4	two hybrid	Mishra RK (2004)	1
FNBP1	0	DNM2	2	pull down, imaging technique	Tsujita K (2006), Kamioka Y (2004)	2
NTRK1	1	HAX1	1	affinity chromatography technology	Emdal KB (2015)	1
DNAAF2	2	AMPH	4	affinity chromatography technology	Huttlin EL (2015)	1
DNM1	21	CEP126	0	two hybrid	Stelzl U (2005)	1
PACSIN1	0	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
DNM2	2	AMPH	4	pull down, pull down	Solomaha E (2005), Elhamdani A (2006)	2
DNM1	21	DNM1	21	x-ray crystallography, two hybrid	Timm D (1994), Mishra RK (2004)	2
IRF2BPL	5	NPM3	2	biochemical	Kristensen AR (2012)	1
NCL	1	NPM3	2	biochemical, biochemical, biochemical	Okuwaki M (2012), Kristensen AR (2012), Wan C (2015)	3
DNMBP	9	DNM1	21	affinity chromatography technology, pull down	Salazar MA (2003), Salazar MA (2003)	2
GRB2	2	NCL	1	two hybrid	Bandyopadhyay S (2010)	1
HAX1	1	AMPH	4	affinity chromatography technology	Huttlin EL (2015)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
CLINT1	1	DNM1	21	pull down	Kalthoff C (2002)	1
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
TMEM9B	0	DNM2	2	affinity chromatography technology	Huttlin EL (2017)	1
NUFIP1	0	DNM3	3	affinity chromatography technology	Huttlin EL (2015)	1