PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FOXC1	0	FOXC2	2	affinity chromatography technology, affinity chromatography technology	Li X (2015), Li X (2015)	2
DLX2	0	MSX2	1	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
FOXC2	2	DLX5	0	affinity chromatography technology	Li X (2015)	1
MSX1	0	HOXC8	0	pull down	Zhang H (1997)	1
FOXO1	2	DLX5	0	affinity chromatography technology	Li X (2015)	1
FOXJ2	3	FOXC1	0	affinity chromatography technology	Li X (2015)	1
FOXC1	0	DLX5	0	affinity chromatography technology	Li X (2015)	1
MSX2	1	MSX1	0	pull down, pull down, two hybrid	Zhang H (1997), Zhang H (1997), Zhang H (1997)	3
FOXJ2	3	DLX5	0	affinity chromatography technology	Li X (2015)	1
TEAD2	2	DLX5	0	affinity chromatography technology	Li X (2015)	1
RBPJ	1	DLX5	0	affinity chromatography technology	Li X (2015)	1
DLX5	0	MSX2	1	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
DLX2	0	HOXC8	0	pull down	Zhang H (1997)	1
DLX5	0	DLX2	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
DLX5	0	DLX5	0	pull down	Zhang H (1997)	1
DLX2	0	MSX1	0	pull down, pull down, two hybrid	Zhang H (1997), Zhang H (1997), Zhang H (1997)	3
FOXI2	1	DLX5	0	affinity chromatography technology	Li X (2015)	1
FOXE1	2	DLX5	0	affinity chromatography technology	Li X (2015)	1
DLX5	0	MSX1	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
FOXA1	2	DLX5	0	affinity chromatography technology	Li X (2015)	1
DLX5	0	HOXC8	0	pull down	Zhang H (1997)	1