PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NLGN3	3	NLGN2	11	affinity chromatography technology	Huttlin EL (2017)	1
SEMA4C	5	DLG2	4	two hybrid	Inagaki S (2001)	1
DLG4	11	KCNJ4	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nehring RB (2000), Leonoudakis D (2004), Inanobe A (2002), Nehring RB (2000)	4
NLGN2	11	DLG2	4	two hybrid	Irie M (1997)	1
DLG4	11	LRP2	13	affinity chromatography technology, two hybrid, two hybrid, pull down	Larsson M (2003), Larsson M (2003), Gotthardt M (2000), Gotthardt M (2000)	4
KHDRBS1	1	DLG4	11	unspecified method	Asbach B (2012)	1
NLGN1	5	DLG2	4	two hybrid	Irie M (1997)	1
KCNA4	5	DLG2	4	affinity chromatography technology	Inanobe A (2002)	1
KCNJ12	0	DLG2	4	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
DYNLL1	0	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
DLGAP1	6	DYNLL2	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000)	6
NOS1	4	DLG2	4	two hybrid	Brenman JE (1996)	1
NLGN3	3	DLG2	4	two hybrid	Irie M (1997)	1
ERBB4	5	DLG4	11	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Garcia RA (2000), Huang YZ (2000), Huang YZ (2000), Garcia RA (2000), Garcia RA (2000), Sardi SP (2006), Hahn CG (2006)	7
GRIN2A	13	DLG2	4	two hybrid	Irie M (1997)	1
KCNJ4	5	DLG2	4	affinity chromatography technology	Inanobe A (2002)	1
LRP2	13	DLG2	4	two hybrid	Larsson M (2003)	1
GUCY1A2	2	DLG4	11	affinity chromatography technology	Russwurm M (2001)	1
KHDRBS1	1	DLG2	4	unspecified method	Asbach B (2012)	1
ATP2B2	10	ATP2B4	5	affinity chromatography technology	Huttlin EL (2017)	1
ERBB4	5	DLG2	4	two hybrid	Garcia RA (2000)	1
GRIN2A	13	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology	Hou XY (2002), Hou XY (2002), Irie M (1997), Irie M (1997), Satoh K (1997), Sans N (2000), Lim IA (2002), Lim IA (2002), Niethammer M (1996), Niethammer M (1996), Papadakis M (2004)	11
NLGN3	3	DLG4	11	two hybrid	Irie M (1997)	1
DLG2	4	MAP1A	1	affinity chromatography technology	Brenman JE (1998)	1
NLGN3	3	NLGN1	5	affinity chromatography technology	Huttlin EL (2017)	1
DYNLL2	0	DLG4	11	pull down, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000)	2
NLGN1	5	DLG4	11	two hybrid, pull down	Irie M (1997), Irie M (1997)	2
DLG4	11	MAP1A	1	two hybrid, affinity chromatography technology	Brenman JE (1998), Brenman JE (1998)	2
DYNLL2	0	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
ATP2B4	5	DLG2	4	affinity chromatography technology	DeMarco SJ (2001)	1
DLGAP1	6	DLG4	11	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Takeuchi M (1997), Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Boeckers TM (1999), Wu H (2000), Kim E (1997), Kim E (1997), Kim E (1997), Kim E (1997)	11
SEMA4C	5	DLG4	11	two hybrid, affinity chromatography technology, pull down	Inagaki S (2001), Inagaki S (2001), Inagaki S (2001)	3
GRIN2B	30	DLG2	4	affinity chromatography technology, two hybrid	Inanobe A (2002), Irie M (1997)	2
DLGAP1	6	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
DLGAP1	6	DYNLL1	0	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Lo KW (2001)	6
NLGN2	11	DLG4	11	two hybrid	Irie M (1997)	1
DLGAP1	6	GRIN2A	13	affinity chromatography technology	Satoh K (1997)	1
NOS1	4	DLG4	11	affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology	Jaffrey SR (1998), Brenman JE (1996), Brenman JE (1996), Brenman JE (1996), Brenman JE (1996)	5
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
KCNA4	5	DLG4	11	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, far western blotting, pull down, pull down, imaging technique, pull down, two hybrid, pull down	Inanobe A (2002), Niethammer M (1998), Kim E (1996), Kim E (1996), Eldstrom J (2002), Eldstrom J (2002), Eldstrom J (2002), Niethammer M (1996), Piserchio A (2002), Imamura F (2002), Imamura F (2002), Imamura F (2002), Kim E (1995), Kim E (1995)	14
ATP2B2	10	DLG2	4	affinity chromatography technology	DeMarco SJ (2001)	1
DYNLL1	0	DYNLL2	0	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
KCNJ12	0	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
DYNLL1	0	DLG4	11	pull down, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000)	2
GUCY1A2	2	DLG2	4	affinity chromatography technology	Russwurm M (2001)	1
GRIN2B	30	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, two hybrid, far western blotting, pull down	Sans N (2003), Inanobe A (2002), Irie M (1997), Niethammer M (1998), Lim IA (2002), Kornau HC (1995), Kornau HC (1995), Niethammer M (1996), Niethammer M (1996), Imamura F (2002)	10
FASLG	0	DLG2	4	unspecified method	Voss M (2009)	1