PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUMO2	0	KDM1A	2	pull down	Ouyang J (2009)	1
H2AFX	1	HIST2H2BE	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Du YC (2006), Lee HS (2010)	3
HNRNPM	1	KIAA0368	0	two hybrid	Gorbea C (2010)	1
H2AFX	1	DHX9	3	affinity chromatography technology, pull down, affinity chromatography technology	Mischo HE (2005), Mischo HE (2005), Mischo HE (2005)	3
HIST2H2AC	1	HIST2H2BE	1	pull down	Long L (2014)	1
KIAA0368	0	DDX1	6	biochemical	Wan C (2015)	1
USP10	2	HIST2H2AC	1	enzymatic study	Draker R (2011)	1
FOXM1	3	SUMO1	0	fluorescent resonance energy transfe	Myatt SS (2013)	1
USP7	14	SUMO2	0	enzymatic study	Lecona E (2016)	1
HERC2	9	PSMD11	0	affinity chromatography technology	Galligan JT (2015)	1
USP7	14	HIST2H2BE	1	affinity chromatography technology	Lecona E (2015)	1
RNF168	0	DHX15	5	affinity chromatography technology	Guturi KK (2016)	1
KIAA0368	0	KIF5B	1	two hybrid, biochemical, imaging technique	Gorbea C (2010), Gorbea C (2010), Gorbea C (2010)	3
SUMO2	0	TP53BP1	3	pull down	Ouyang J (2009)	1
H2AFX	1	HIST1H1C	2	affinity chromatography technology	Huttlin EL (2017)	1
USP7	14	HIST2H2AC	1	affinity chromatography technology, enzymatic study	Lecona E (2015), Yu M (2016)	2
UBR5	13	UBE2D3	1	pull down	Honda Y (2002)	1
UBC	7	DHX9	3	affinity chromatography technology	Matsumoto M (2005)	1
TP53BP1	3	H2AFX	1	affinity chromatography technology, imaging technique, imaging technique, unspecified method, imaging technique, affinity chromatography technology, imaging technique, imaging technique	Sengupta S (2004), Sengupta S (2004), Fernandez-Capetillo O (2002), Ward IM (2003), Walters DK (2011), Stewart GS (2003), Fraser M (2011), Rassoolzadeh H (2015)	8
HERC2	9	UBE2D1	0	pull down	Bai B (2016)	1
HIST1H1C	2	NCL	1	affinity chromatography technology, affinity chromatography technology, pull down	Kim K (2008), Kim K (2008), Kim K (2008)	3
RNF168	0	DDX21	0	affinity chromatography technology	Guturi KK (2016)	1
RNF168	0	CCDC174	1	affinity chromatography technology	Hein MY (2015)	1
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
RNF168	0	UBE2D1	0	pull down	OConnor HF (2015)	1
EWSR1	2	RNF168	0	biochemical	Havugimana PC (2012)	1
RNF168	0	SUMO3	0	affinity chromatography technology	Shire K (2016)	1
UBC	7	LIMA1	4	pull down	Nathan JA (2013)	1
KIAA0368	0	PSMD11	0	biochemical	Kristensen AR (2012)	1
MKI67	7	KIAA0368	0	two hybrid	Gorbea C (2010)	1
PCM1	5	EWSR1	2	affinity chromatography technology	Akimov V (2011)	1
DHX9	3	HNRNPM	1	biochemical	Kristensen AR (2012)	1
RNF168	0	NCL	1	affinity chromatography technology	Guturi KK (2016)	1
DHX9	3	NCL	1	affinity chromatography technology, affinity chromatography technology	Chu L (2012), Salvetti A (2016)	2
RNF168	0	SUMO1	0	affinity chromatography technology	Guturi KK (2016)	1
RNF11	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
KIF5B	1	RNF168	0	biochemical	Havugimana PC (2012)	1
UBC	7	SUMO3	0	affinity chromatography technology	Sahin U (2014)	1
HIST2H2AC	1	UBC	7	pull down, pull down	Long L (2014), Zhang X (2017)	2
USP7	14	EWSR1	2	two hybrid	Lim J (2006)	1
RNF168	0	KIAA0368	0	two hybrid	Gorbea C (2010)	1
RNF168	0	NUB1	2	affinity chromatography technology	Hein MY (2015)	1
SUMO2	0	MKI67	7	pull down	Ouyang J (2009)	1
SUMO2	0	DDX21	0	pull down	Ouyang J (2009)	1
RNF168	0	TBP	0	affinity chromatography technology	Hein MY (2015)	1
RNF168	0	RPRD1B	1	affinity chromatography technology	Hein MY (2015)	1
NCL	1	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park JJ (2015), Park JJ (2015), Lim KH (2015), Lim KH (2015)	4
RNF11	0	USP7	14	affinity chromatography technology	Poulsen SL (2013)	1
TRIP12	20	UBE2D1	0	pull down, pull down, pull down, pull down	Park Y (2008), Schwarz SE (1998), An CI (2013), Park Y (2009)	4
UBC	7	HERC2	9	affinity chromatography technology, pull down	Rendtlew Danielsen J (2012), Zhang X (2017)	2
TOP2A	2	BRCA2	6	genetic interference	Srivas R (2016)	1
DHX9	3	USP7	14	biochemical	Wan C (2015)	1
UBC	7	HNRNPM	1	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
DDX1	6	HNRNPM	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
RNF168	0	USP10	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guturi KK (2016), Guturi KK (2016), Guturi KK (2016)	3
RNF168	0	SRCAP	30	affinity chromatography technology	Hein MY (2015)	1
UBC	7	DHX15	5	pull down	Nathan JA (2013)	1
USP10	2	UBC	7	enzymatic study, unspecified method, pull down	Bomberger JM (2009), Ernst A (2013), Kwasna D (2018)	3
USP7	14	RNF168	0	pull down, affinity chromatography technology	Zhu Q (2015), Zhu Q (2015)	2
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
RNF168	0	TOP2A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study	Guturi KK (2016), Guturi KK (2016), Guturi KK (2016), Guturi KK (2016), Guturi KK (2016)	5
RNF168	0	RNF168	0	enzymatic study	Stewart GS (2009)	1
DBN1	1	RAI14	4	affinity chromatography technology	Hein MY (2015)	1
SUMO2	0	TOP2A	2	pull down	Ouyang J (2009)	1
KDM1A	2	KIF5B	1	biochemical	Havugimana PC (2012)	1
USP7	14	UBB	4	x-ray crystallography	Rouge L (2016)	1
RNF168	0	HNRNPM	1	affinity chromatography technology	Guturi KK (2016)	1
RNF168	0	HERC2	9	affinity chromatography technology	Bekker-Jensen S (2010)	1
UBR5	13	UBC	7	pull down, x-ray crystallography, pull down	Kozlov G (2007), Kozlov G (2007), Zhang X (2017)	3
UBC	7	PABPC4	2	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
UBC	7	MKI67	7	affinity chromatography technology	Matsumoto M (2005)	1
DHX9	3	KIF5B	1	biochemical	Havugimana PC (2012)	1
DHX9	3	EWSR1	2	pull down, affinity chromatography technology, affinity chromatography technology	Toretsky JA (2006), Toretsky JA (2006), Elzi DJ (2014)	3
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
RNF168	0	LIMA1	4	affinity chromatography technology	Guturi KK (2016)	1
RNF168	0	KDM4A	3	enzymatic study	Mallette FA (2012)	1
RNF168	0	TRIP12	20	affinity chromatography technology	Gudjonsson T (2012)	1
USP7	14	TRIP12	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Liu X (2016), Liu X (2016)	3
RNF168	0	TJP1	2	affinity chromatography technology	Guturi KK (2016)	1
RNF168	0	H2AFZ	1	enzymatic study	OConnor HF (2015)	1
RNF168	0	HIST2H2BE	1	affinity chromatography technology	Pinato S (2011)	1
TP53BP1	3	RNF168	0	imaging technique, imaging technique, affinity chromatography technology	Galanty Y (2009), Bohgaki T (2011), Peng B (2015)	3
RNF168	0	PALB2	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Luijsterburg MS (2017), Luijsterburg MS (2017), Luijsterburg MS (2017), Luijsterburg MS (2017)	4
UBE2N	1	HERC2	9	affinity chromatography technology, pull down	Bekker-Jensen S (2010), Bai B (2016)	2
PSMD11	0	DCTN1	6	biochemical	Wan C (2015)	1
LAPTM5	3	RNF168	0	two hybrid	Colland F (2004)	1
TOP2A	2	PALB2	3	genetic interference	Srivas R (2016)	1
RNF168	0	PABPC4	2	affinity chromatography technology	Guturi KK (2016)	1
HIST2H2BE	1	UBC	7	pull down	Long L (2014)	1
EWSR1	2	SUMO1	0	bioid	Elzi DJ (2014)	1
UBE2D1	0	UBR5	13	biochemical	Havugimana PC (2012)	1
UBE2G2	0	RNF168	0	two hybrid	van Wijk SJ (2009)	1
UBE2D1	0	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
H2AFX	1	UBC	7	affinity chromatography technology	Sharma N (2013)	1
WBP2	0	RNF168	0	two hybrid	Lim SK (2016)	1
DHX9	3	TBP	0	affinity chromatography technology	Pellizzoni L (2001)	1
UBC	7	PSMD11	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
NCL	1	DHX15	5	affinity chromatography technology	Salvetti A (2016)	1
RNF168	0	UBR5	13	affinity chromatography technology	Gudjonsson T (2012)	1
RNF11	0	RNF168	0	two hybrid	Colland F (2004)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
H2AFX	1	DDX21	0	pull down	Kobayashi J (2012)	1
USP7	14	DBN1	1	affinity chromatography technology	Bhattacharya S (2015)	1
UBE2N	1	RNF11	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Scheper J (2009), Colland F (2004), Poulsen SL (2013)	5
EWSR1	2	SUMO3	0	affinity chromatography technology	Elzi DJ (2014)	1
KIAA0368	0	DCTN1	6	imaging technique	Gorbea C (2010)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
H2AFZ	1	SRCAP	30	affinity chromatography technology	Boenisch C (2012)	1
PCM1	5	KIAA0368	0	two hybrid	Rual JF (2005)	1
UBE2E1	1	RNF11	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
TRIP12	20	UBC	7	affinity chromatography technology	Park Y (2009)	1
RNF168	0	HIST1H2AB	0	enzymatic study	Jacquet K (2016)	1
WBP2	0	UBC	7	two hybrid	Lim SK (2016)	1
TACC3	1	RNF168	0	affinity chromatography technology	Hein MY (2015)	1
HNRNPM	1	SMARCA5	4	biochemical	Havugimana PC (2012)	1
RNF168	0	HIST2H2AA3	0	affinity chromatography technology	Pinato S (2011)	1
PALB2	3	BRCA2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Hayakawa T (2010), Zhang F (2009), Sy SM (2009), Zhang F (2009), Xia B (2007), Xia B (2006), Xia B (2006), Xia B (2006), Sy SM (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Zhang F (2012), Oliver AW (2009), Oliver AW (2009), Oliver AW (2009), Anantha RW (2013), Bleuyard JY (2012), Brough R (2012), Orthwein A (2015), Trego KS (2016), Trego KS (2016), Trego KS (2016), Simhadri S (2014), Byrd PJ (2016), Park JY (2014), Park JY (2014), Ma J (2012), Ma J (2012), Luijsterburg MS (2017), Luijsterburg MS (2017), Foo TK (2017)	32
LIMA1	4	RAI14	4	affinity chromatography technology	Hein MY (2015)	1
DHX9	3	TOP2A	2	affinity chromatography technology	Zhou K (2003)	1
UBC	7	NCL	1	affinity chromatography technology	Matsumoto M (2005)	1
RNF168	0	JMJD1C	10	pull down	Watanabe S (2013)	1
HERC2	9	PCM1	5	affinity chromatography technology, affinity chromatography technology	Galligan JT (2015), Gupta GD (2015)	2
EWSR1	2	RPRD1B	1	bioid	Elzi DJ (2014)	1
RNF168	0	H2AFX	1	enzymatic study	Pinato S (2009)	1
RNF168	0	MKI67	7	affinity chromatography technology	Guturi KK (2016)	1
UBE2D3	1	DBN1	1	two hybrid	Vinayagam A (2011)	1
RNF168	0	FAM45A	1	affinity chromatography technology	Hein MY (2015)	1
H2AFX	1	NCL	1	pull down, pull down	Kobayashi J (2012), Kobayashi J (2012)	2
RNF168	0	DHX9	3	affinity chromatography technology	Guturi KK (2016)	1
HIST1H2AB	0	UBC	7	affinity chromatography technology	Sharma N (2013)	1
NUB1	2	UBC	7	pull down, affinity chromatography technology	Nakayasu ES (2013), Nakayasu ES (2013)	2
RNF168	0	HIST1H1C	2	pull down	Thorslund T (2015)	1
DDX1	6	RNF168	0	biochemical	Havugimana PC (2012)	1
HERC2	9	UBE2D3	1	pull down	Wu W (2010)	1
RNF168	0	FOXM1	3	affinity chromatography technology, affinity chromatography technology	Kongsema M (2016), Kongsema M (2016)	2
RNF168	0	BRCA2	6	affinity chromatography technology	Luijsterburg MS (2017)	1
TAF15	2	RNF168	0	biochemical	Havugimana PC (2012)	1
DHX15	5	PABPC4	2	biochemical	Wan C (2015)	1
H2AFX	1	BRCA2	6	affinity chromatography technology, affinity chromatography technology, pull down	Heo K (2008), Heo K (2008), Krum SA (2010)	3
RNF168	0	UBE2D3	1	pull down, pull down, two hybrid	Mallette FA (2012), Pinato S (2009), Schimmack G (2017)	3
UBE2G2	0	KIAA0368	0	two hybrid	Gorbea C (2010)	1
FOXM1	3	SMARCA5	4	affinity chromatography technology	Li X (2015)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
EWSR1	2	SUMO2	0	bioid	Elzi DJ (2014)	1
RNF168	0	PSMD11	0	affinity chromatography technology	Hein MY (2015)	1
UBE2E1	1	H2AFZ	1	affinity chromatography technology	Wheaton K (2017)	1
HIST2H2BE	1	NCL	1	pull down	Angelov D (2006)	1
RNF168	0	POC1A	3	biochemical	Havugimana PC (2012)	1
RNF168	0	UBE2E1	1	pull down	Poulsen M (2012)	1
RNF168	0	SUMO2	0	affinity chromatography technology, pull down	Shire K (2016), Shire K (2016)	2
KDM1A	2	TP53BP1	3	pull down	Peng B (2015)	1
LIMA1	4	DBN1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
RNF168	0	KDM1A	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Mosammaparast N (2013), Mosammaparast N (2013), Peng B (2015), Peng B (2015), Peng B (2015)	5
UBE2D3	1	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
NCL	1	SMARCA5	4	affinity chromatography technology	Salvetti A (2016)	1
RNF168	0	UBE2N	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakada S (2010), Stewart GS (2009), Zhang X (2013), Zhao H (2014), Stewart GS (2009)	5
DHX9	3	DDX1	6	biochemical	Kristensen AR (2012)	1
RNF168	0	PDCD11	5	affinity chromatography technology	Guturi KK (2016)	1
UBE2G2	0	UBC	7	x-ray crystallography, pull down, pull down	Bocik WE (2011), Bocik WE (2011), Reyes LF (2006)	3
DCTN1	6	RNF168	0	biochemical	Havugimana PC (2012)	1
UBC	7	HIST2H2AA3	0	pull down	Zhang X (2017)	1
UBC	7	H2AFZ	1	affinity chromatography technology	Matsumoto M (2005)	1
RNF168	0	SMARCA5	4	affinity chromatography technology, affinity chromatography technology	Smeenk G (2012), Smeenk G (2012)	2
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
HIST2H2AC	1	TAF15	2	pull down	Hoffmann A (1996)	1
H2AFX	1	HIST2H2AC	1	affinity chromatography technology	Lee HS (2010)	1
RNF168	0	UBB	4	affinity chromatography technology	Guturi KK (2016)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
RNF168	0	BCL10	0	affinity chromatography technology	Zhao H (2014)	1
UBC	7	LAPTM5	3	pull down	Pak Y (2006)	1
RNF168	0	HIST2H2AC	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Stewart GS (2009), Stewart GS (2009), Pinato S (2011), Poulsen M (2012), Mattiroli F (2012)	5
TBP	0	USP10	2	affinity chromatography technology	Li L (2015)	1
NCL	1	DDX21	0	affinity chromatography technology	Salvetti A (2016)	1
RNF168	0	PCM1	5	affinity chromatography technology	Guturi KK (2016)	1
TP53BP1	3	UBC	7	affinity chromatography technology	Benada J (2015)	1
PALB2	3	HIST2H2BE	1	affinity chromatography technology	Bleuyard JY (2012)	1
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5
RNF168	0	RAI14	4	affinity chromatography technology	Guturi KK (2016)	1
RNF168	0	DBN1	1	affinity chromatography technology	Guturi KK (2016)	1
HIST2H2AC	1	NCL	1	pull down	Angelov D (2006)	1
USP7	14	UBE2E1	1	unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Wheaton K (2017)	6
RNF11	0	PSMD11	0	affinity chromatography technology	Poulsen SL (2013)	1