PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ENAH	0	EVL	4	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
XIRP1	9	EVL	4	two hybrid	van der Ven PF (2006)	1
VASP	0	ENAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
XIRP1	9	VASP	0	two hybrid, far western blotting, far western blotting	van der Ven PF (2006), van der Ven PF (2006), van der Ven PF (2006)	3
XIRP1	9	FLNC	8	pull down, two hybrid, far western blotting	Kley RA (2013), van der Ven PF (2006), van der Ven PF (2006)	3
XIRP1	9	NEBL	4	two hybrid, pull down, unspecified method, protein complementation assay	Eulitz S (2013), Eulitz S (2013), Eulitz S (2013), Eulitz S (2013)	4
VASP	0	EVL	4	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
XIRP1	9	NEB	21	two hybrid, pull down	Eulitz S (2013), Eulitz S (2013)	2
XIRP1	9	ENAH	0	two hybrid	van der Ven PF (2006)	1