PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCDC185	3	LINGO1	3	affinity chromatography technology	Huttlin EL (2017)	1
PDLIM7	0	CCDC185	3	two hybrid	Rual JF (2005)	1
KXD1	1	CCDC185	3	two hybrid	Rual JF (2005)	1
KRTAP4-12	2	LINGO1	3	two hybrid	Rual JF (2005)	1
MAGEA11	1	CCDC185	3	two hybrid	Rual JF (2005)	1
MDFI	1	CCDC185	3	two hybrid	Rual JF (2005)	1
CCDC185	3	LURAP1	0	two hybrid	Rual JF (2005)	1
CALCOCO2	0	CCDC185	3	two hybrid	Rual JF (2005)	1
KRT40	0	CCDC185	3	two hybrid	Rolland T (2014)	1
KRTAP4-12	2	CCDC185	3	two hybrid	Rual JF (2005)	1
KRT15	2	CCDC185	3	two hybrid	Rual JF (2005)	1
CCDC85B	0	CCDC185	3	two hybrid	Rual JF (2005)	1
CCDC185	3	KRTAP10-7	0	two hybrid	Rolland T (2014)	1