PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POT1	2	DCX	5	two hybrid	Lee OH (2011)	1
TINF2	1	DCX	5	two hybrid	Lee OH (2011)	1
GOLGA2	2	KIFC3	3	two hybrid	Rolland T (2014)	1
DGUOK	1	APP	1	pull down	Olah J (2011)	1
RNF13	0	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
TRIM23	3	DCX	5	two hybrid	Rolland T (2014)	1
DCX	5	CUL1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCX	5	RINT1	1	two hybrid	Rolland T (2014)	1
DNAAF2	2	APP	1	pull down	Olah J (2011)	1
MID2	1	SPAG5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	4
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
PPP1CA	3	CUL1	7	affinity chromatography technology	Flores-Delgado G (2007)	1
HAX1	1	DCLK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCLK1	2	APP	1	pull down	Olah J (2011)	1
DCX	5	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
ACD	1	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
DCX	5	MID2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
DCX	5	MEOX1	0	two hybrid	Rolland T (2014)	1
HAX1	1	DCX	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP1R9B	1	PPP1CA	3	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsieh-Wilson LC (1999), Hsieh-Wilson LC (1999), Esteves SL (2012), Santra M (2009), Santra M (2009), Colland F (2004), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017)	10
DCX	5	ZBTB5	0	two hybrid	Rolland T (2014)	1
FBXO25	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010), Hagens O (2006), Maragno AL (2006)	4
DNAAF2	2	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	DIS3	2	affinity chromatography technology	Emdal KB (2015)	1
AGTR1	4	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
DCX	5	TRIM27	2	two hybrid	Rolland T (2014)	1
DCX	5	CALCOCO2	0	two hybrid	Rolland T (2014)	1
KIFC3	3	MID2	1	two hybrid	Rolland T (2014)	1
NTRK1	1	PAFAH1B1	3	affinity chromatography technology	Emdal KB (2015)	1
RGL4	3	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
NUFIP1	0	DCLK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
SPP1	0	DCX	5	two hybrid	Long P (2012)	1
FBXO25	1	DCX	5	enzymatic study	Teixeira FR (2013)	1
NTRK1	1	RINT1	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CUL1	7	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PPP1CA	3	affinity chromatography technology	Emdal KB (2015)	1
NDUFA10	2	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
DPF3	2	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
KIFC3	3	TRIM27	2	two hybrid	Rolland T (2014)	1
POT1	2	ACD	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Liu J (2015), Hein MY (2015), Huttlin EL (2017)	12
MEOX1	0	APP	1	pull down	Olah J (2011)	1
DNAAF2	2	DCLK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TINF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	USP9X	15	affinity chromatography technology	Emdal KB (2015)	1
PAFAH1B1	3	DCX	5	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Caspi M (2000), Caspi M (2000), Caspi M (2000), Caspi M (2000), Caspi M (2003)	5
PPP1CA	3	DCX	5	affinity chromatography technology, imaging technique	Santra M (2009), Santra M (2009)	2
DGUOK	1	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
KIFC3	3	APP	1	pull down	Olah J (2011)	1
DCX	5	DCLK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
DCX	5	GOLGA2	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TERF1	1	USP9X	15	affinity chromatography technology	Giannone RJ (2010)	1
TRIM23	3	KIFC3	3	two hybrid	Rolland T (2014)	1
DCX	5	KRT40	0	two hybrid	Rolland T (2014)	1
TERF1	1	DCX	5	two hybrid	Lee OH (2011)	1
LGALS9C	0	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	GOLGA2	2	affinity chromatography technology	Emdal KB (2015)	1
DGUOK	1	DCLK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CALCOCO2	0	MID2	1	two hybrid	Rolland T (2014)	1
DCX	5	KIFC3	3	two hybrid	Rolland T (2014)	1
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
MTERF2	0	DCX	5	affinity chromatography technology	Huttlin EL (2017)	1
RINT1	1	SPAG5	1	affinity chromatography technology	Huttlin EL (2017)	1
DCX	5	DCX	5	pull down	Caspi M (2000)	1
DCX	5	DIS3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUFIP1	0	DCX	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCX	5	IKZF1	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
DCX	5	SPAG5	1	two hybrid	Rolland T (2014)	1
KIFC3	3	ZBTB5	0	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	DCX	5	affinity chromatography technology	Emdal KB (2015)	1
GOLGA2	2	MID2	1	two hybrid	Rolland T (2014)	1
DCX	5	NMNAT3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCX	5	USP9X	15	two hybrid, affinity chromatography technology, affinity chromatography technology	Friocourt G (2005), Friocourt G (2005), Friocourt G (2005)	3
PPP1R9B	1	DCX	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Santra M (2009), Santra M (2006), Santra M (2006)	3
NTRK1	1	HAX1	1	affinity chromatography technology	Emdal KB (2015)	1
ACD	1	DCX	5	two hybrid	Lee OH (2011)	1
DCX	5	APP	1	pull down	Olah J (2011)	1
TINF2	1	ACD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	11
KIFC3	3	KRT40	0	two hybrid	Rolland T (2014)	1
NTRK1	1	NDUFA10	2	affinity chromatography technology	Emdal KB (2015)	1