PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EPAS1	6	BATF	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
EPAS1	6	BATF3	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CLOCK	0	DBP	1	two hybrid	Wallach T (2013)	1
DBP	1	BATF2	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
EPAS1	6	BATF2	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF	0	DBP	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
EPAS1	6	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF2	0	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DBP	1	CEBPG	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	ATF3	0	affinity chromatography technology, pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Chen BP (1996), Chen BP (1996), Reinke AW (2013), Reinke AW (2013)	4
DBP	1	CEBPA	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
DBP	1	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), Wang J (2011)	3
BATF3	0	BATF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	CEBPA	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Marwarha G (2016), Marwarha G (2016), Marwarha G (2016)	3
ATF3	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF3	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	BATF	0	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Rual JF (2005), Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	4
BATF2	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPA	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
IFI16	1	DBP	1	affinity chromatography technology	Diner BA (2015)	1
BATF3	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
EPAS1	6	DBP	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	BATF3	0	fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Rolland T (2014)	2
BATF2	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DBP	1	ATF3	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF3	0	DBP	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DBP	1	HLF	0	two hybrid	Wang J (2011)	1
ATF3	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF3	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPG	1	DDIT3	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Hattori T (2003), Rolland T (2014)	3