Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
DBH	1621	DISULFIRAM	CHEMBL964	inhibitor	DrugBank	19720750
DBH	1621	NEPICASTAT	CHEMBL1188395		TdgClinicalTrial
DBH	1621	ASCORBATE	CHEMBL196		DrugBank	1894598, 17139284, 17016423, 10947967, 9505234
DBH	1621	TESTOSTERONE	CHEMBL386630		NCI	824661

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
DBH	rs1611115	CC	methylphenidate	efficacy	no		Genotype CC is not associated with response to methylphenidate in people with Attention Deficit Disorder with Hyperactivity as compared to genotypes CT + TT.	23131881	981478823
DBH	rs2873804	CC	bupropion	efficacy	yes	Patients with the CC genotype show a greater reduction in HAMD17 scores as compared to patients with the CT or TT genotypes.	Genotype CC is associated with increased response to bupropion in people with Depressive Disorder, Major as compared to genotypes CT + TT.	22947179	1450814595
DBH	rs1611115	CT + TT	levodopa	efficacy	yes	Not corrected for multiple testing. The CT/TT group had decrease odds of having cocaine-positive urine (odds ratio=0.127, 95% confidence interval 0.026¿0.633) under levodopa treatment, whereas for placebo, the odds of having cocaine-positive urine increased over time (odds ratio=1.65, 95% confidence interval 1.399¿1.948). For CC genotype, however, the treatment by time interaction was not significant (F1,86=0.00, P=0.991).	Genotypes CT + TT are associated with increased response to levodopa in people with Cocaine-Related Disorders as compared to genotype CC.	24809448	1184469118
DBH	rs1611115	CT + TT	naltrexone	efficacy	yes	Veterans. Two-thirds had a lifetime history of major depressive disorder, 37% had a lifetime history of post-traumatic stress disorder. 65% took SSRIs and 39% took anticonvulsants. 84-day treatment period. Patients who carried the T allele had more abstinence from heavy drinking days as compared to those with the CC genotype. Note that heavy drinking days was defined as more than four standard drinks in a day.	Genotypes CT + TT is associated with increased response to naltrexone in men with Alcoholism as compared to genotype CC.	24724887	1444700343