PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GATA2	0	ZFPM1	8	affinity chromatography technology, affinity chromatography technology	Freson K (2003), Huttlin EL (2017)	2
ZFPM1	8	GATA1	1	affinity chromatography technology, affinity chromatography technology	Kadri Z (2009), Kadri Z (2009)	2
ZFPM1	8	MTA1	3	x-ray crystallography	Lejon S (2011)	1
CTBP2	7	ZFPM1	8	two hybrid	Wang J (2011)	1
MTA1	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Cui S (2011), Cui S (2011), Rolland T (2014), Huttlin EL (2015), Alqarni SS (2014), Alqarni SS (2014), Alqarni SS (2014), Wan C (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016), Millard CJ (2016), Hauri S (2016)	15
RBBP4	3	ZFPM1	8	pull down, x-ray crystallography, x-ray crystallography	Lejon S (2011), Lejon S (2011), Lejon S (2011)	3
TRIM21	0	ZFPM1	8	affinity chromatography technology	Rhodes DA (2007)	1
GSK3B	1	ZFPM1	8	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
DEFA6	0	ZFPM1	8	affinity chromatography technology	Huttlin EL (2017)	1
ERP44	1	ZFPM1	8	affinity chromatography technology	Huttlin EL (2017)	1