PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FYN	1	SYK	3	affinity chromatography technology, pull down	Deckert M (1998), Deckert M (1998)	2
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
GRASP	1	PTPN11	20	affinity chromatography technology	Hirose M (2004)	1
SRC	2	SYK	3	enzymatic study, affinity chromatography technology, enzymatic study	Kurosaki T (1994), Asazuma N (1997), Hirose M (2004)	3
SYK	3	GRM1	4	affinity chromatography technology, affinity chromatography technology	Hirose M (2004), Hirose M (2004)	2
FYN	1	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Tang H (1999), Chernock RD (2001)	2
SRC	2	GRM1	4	affinity chromatography technology, affinity chromatography technology	Hirose M (2004), Hirose M (2004)	2
GRASP	1	SRC	2	affinity chromatography technology, enzymatic study	Hirose M (2004), Hirose M (2004)	2
SRC	2	PTPN11	20	enzymatic study	Vogel W (1996)	1
GRASP	1	PSD	1	affinity chromatography technology	Mo J (2012)	1
GRASP	1	GRM1	4	affinity chromatography technology	Hirose M (2004)	1
FYN	1	GRM1	4	affinity chromatography technology, affinity chromatography technology	Hirose M (2004), Hirose M (2004)	2
FYN	1	GRASP	1	enzymatic study	Hirose M (2004)	1
GRASP	1	SYK	3	affinity chromatography technology	Hirose M (2004)	1