PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTK2	2	PPP1CB	9	affinity chromatography technology, affinity chromatography technology	Fresu M (2001), Flores-Delgado G (2007)	2
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
TRIM25	5	DAG1	3	affinity chromatography technology	Choudhury NR (2017)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
ELAVL1	0	DAG1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
DAG1	3	NCK1	0	pull down, affinity chromatography technology	Sotgia F (2001), Sotgia F (2001)	2
KRAS	1	CDH5	2	genetic interference	Luo J (2009)	1
MAP2	7	FYN	1	affinity chromatography technology	Zamora-Leon SP (2001)	1
ELAVL1	0	TCTN2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PRX	3	DAG1	3	affinity chromatography technology	Sherman DL (2001)	1
AGR3	2	DAG1	3	two hybrid	Fletcher GC (2003)	1
ITGB1	4	VCL	6	biochemical	Havugimana PC (2012)	1
CDH1	4	ITGB1	4	bioid	Guo Z (2014)	1
ELAVL1	0	PTK2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
DMD	6	UTRN	6	affinity chromatography technology	Huttlin EL (2017)	1
TLN1	5	TUBA1A	13	fluorescent resonance energy transfe	Cerecedo D (2008)	1
FKBP9	1	DAG1	3	affinity chromatography technology	Huttlin EL (2017)	1
CSK	3	SHC1	0	pull down, affinity chromatography technology	Sato K (2002), Brehme M (2009)	2
MAP2	7	ACTN1	5	pull down	Nakamura A (1989)	1
CDH1	4	VCL	6	affinity chromatography technology, affinity chromatography technology, bioid	Hazan RB (1997), Hazan RB (1998), Guo Z (2014)	3
LGALS9	0	ITGB1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCDHGA5	2	GINM1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRIM25	5	LAMA5	20	affinity chromatography technology	Choudhury NR (2017)	1
PPP1CB	9	DAG1	3	biochemical	Wan C (2015)	1
HLA-DPA1	1	DAG1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAV3	0	CAV1	0	affinity chromatography technology	Huttlin EL (2017)	1
AGR2	0	DAG1	3	two hybrid	Fletcher GC (2003)	1
SHC1	0	CLIC4	3	biochemical	Wan C (2015)	1
CDH1	4	DNAJB1	1	bioid	Guo Z (2014)	1
PTK2	2	SH3KBP1	1	affinity chromatography technology	Schmidt MH (2003)	1
IL13RA2	0	DAG1	3	affinity chromatography technology	Huttlin EL (2017)	1
TLN1	5	PTK2	2	affinity chromatography technology, pull down, affinity chromatography technology	Chen HC (1995), Chen HC (1995), Zheng C (1998)	3
ITGB1	4	ACTN1	5	pull down	Otey CA (1990)	1
TRIM25	5	WWC1	5	affinity chromatography technology	Choudhury NR (2017)	1
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
CDH1	4	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Genda T (2000), Swaminathan G (2011), Shen Y (2008), Guo Z (2014)	4
KRAS	1	GRB2	2	genetic interference	Hart T (2015)	1
PCDHAC2	1	DAG1	3	affinity chromatography technology	Huttlin EL (2017)	1
PTK2	2	DAG1	3	affinity chromatography technology	Cerecedo D (2008)	1
CORO7	0	DAG1	3	biochemical	Havugimana PC (2012)	1
CDH1	4	DAG1	3	bioid	Guo Z (2014)	1
LGALS9C	0	LGALS9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KRAS	1	SHC1	0	genetic interference	Hart T (2015)	1
SRC	2	CORO7	0	enzymatic study, affinity chromatography technology	Rybakin V (2008), Rybakin V (2008)	2
TRIM25	5	PPP1CB	9	affinity chromatography technology	Choudhury NR (2017)	1
ACTN1	5	DAG1	3	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Cerecedo D (2008), Cerecedo D (2008), Cerecedo D (2008)	3
NCK1	0	PTK2	2	pull down, affinity chromatography technology, pull down	Minegishi M (1996), Goicoechea SM (2002), Goicoechea SM (2002)	3
ITGB1	4	DAG1	3	fluorescent resonance energy transfe, affinity chromatography technology	Cerecedo D (2008), Cerecedo D (2008)	2
DAG1	3	CAV1	0	pull down	Sotgia F (2001)	1
SHC1	0	TUBA1A	13	affinity chromatography technology	Brehme M (2009)	1
CDH5	2	PTK2	2	affinity chromatography technology	Chang CC (2012)	1
ELAVL1	0	SH3KBP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PTK2	2	FYN	1	affinity chromatography technology, x-ray crystallography	Messina S (2003), Arold ST (2001)	2
GRB2	2	DAG1	3	pull down, affinity chromatography technology	Yang B (1995), Yang B (1995)	2
DAG1	3	UTRN	6	pull down, pull down	James M (2000), Tommasi di Vignano A (2000)	2
TNFSF8	0	DAG1	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	ACTN1	5	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PTK2	2	affinity chromatography technology	Choudhury NR (2017)	1
ITGB1	4	SHC1	0	affinity chromatography technology	Lee DY (2010)	1
CSK	3	PTK2	2	affinity chromatography technology	Bergman M (1995)	1
CAV3	0	DAG1	3	biochemical, affinity chromatography technology, pull down	Sotgia F (2000), Sotgia F (2000), Sotgia F (2000)	3
TUBA1A	13	MAP2	7	affinity chromatography technology, pull down	Cerecedo D (2008), Nakamura A (1989)	2
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
VCL	6	TUBA1A	13	fluorescent resonance energy transfe, affinity chromatography technology	Cerecedo D (2008), Cerecedo D (2008)	2
ITGB1	4	PTK2	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Lin TY (2016), Lee DY (2010), Moon HE (2015)	3
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
GRB2	2	MAP2	7	pull down, pull down	Lim RW (2000), Zamora-Leon SP (2001)	2
FYN	1	CAV1	0	biochemical	Mastick CC (1997)	1
PTK2	2	SRC	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Hecker TP (2002), Angers-Loustau A (1999), Relou IA (2003), Messina S (2003), Lebrun P (1998), Ponnala S (2011), Grossmann A (2015), Chen TC (2014), Lee J (2013), Reiske HR (2000)	11
PPP1CB	9	ACTN1	5	affinity chromatography technology	Hein MY (2015)	1
LGALS9C	0	DAG1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDH5	2	DAG1	3	affinity chromatography technology	Huttlin EL (2017)	1
CLIC4	3	DAG1	3	biochemical	Wan C (2015)	1
DAG1	3	CSK	3	pull down, affinity chromatography technology	Sotgia F (2001), Sotgia F (2001)	2
LGALS9	0	DAG1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DAG1	3	LAMA2	9	pull down	Yamada H (1994)	1
TNF	0	CAV1	0	affinity chromatography technology	Legler DF (2003)	1
CSK	3	FYN	1	affinity chromatography technology	Takeuchi M (1993)	1
DAG1	3	FYN	1	pull down, affinity chromatography technology	Sotgia F (2001), Sotgia F (2001)	2
CSK	3	SRC	2	pull down	Sabe H (1994)	1
VPS45	0	DAG1	3	biochemical	Wan C (2015)	1
ITGB1	4	TLN1	5	unspecified method, biochemical, pull down, pull down	Martel V (2001), Havugimana PC (2012), Anthis NJ (2009), Anthis NJ (2009)	4
CAV1	0	CSK	3	two hybrid	Cao H (2002)	1
CDH1	4	NCK1	0	bioid	Guo Z (2014)	1
TRIM25	5	VCL	6	affinity chromatography technology	Choudhury NR (2017)	1
SRC	2	DAG1	3	enzymatic study, pull down, affinity chromatography technology	Sotgia F (2001), Sotgia F (2001), Sotgia F (2001)	3
ELAVL1	0	PPP1CB	9	affinity chromatography technology	Abdelmohsen K (2009)	1
GINM1	1	DAG1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SHC1	0	CDH5	2	affinity chromatography technology	Zanetti A (2002)	1
SRC	2	MAP2	7	pull down	Lim RW (2000)	1
FYN	1	TNF	0	pull down	Simms HH (1997)	1
DAG1	3	MAP2	7	affinity chromatography technology, pull down	Cerecedo D (2008), Cerecedo D (2008)	2
ITGB1	4	TUBA1A	13	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Cerecedo D (2008), Cerecedo D (2008), Cerecedo D (2008)	3
GRB2	2	PTK2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid	Sieg DJ (2000), Angers-Loustau A (1999), Hildebrand JD (1996), Messina S (2003), Arold ST (2002), Vinayagam A (2011)	6
ELAVL1	0	ITGB1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
WWC1	5	DAG1	3	affinity chromatography technology	Toloczko A (2017)	1
DAG1	3	LAMA5	20	pull down	Shimizu H (1999)	1
CAV1	0	SRC	2	pull down	Li S (1996)	1
SHC1	0	PTK2	2	affinity chromatography technology	Hecker TP (2002)	1
TLN1	5	DAG1	3	fluorescent resonance energy transfe	Cerecedo D (2008)	1
PCDHGB4	0	DAG1	3	affinity chromatography technology	Huttlin EL (2017)	1
NCK1	0	TUBA1A	13	affinity chromatography technology	Jeong DG (2007)	1
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
CDH1	4	SH3KBP1	1	bioid	Guo Z (2014)	1
SH3KBP1	1	DAG1	3	affinity chromatography technology	Havrylov S (2009)	1
SRC	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Narita T (2005), Schroeder B (2012)	2
TCTN2	2	DAG1	3	affinity chromatography technology	Huttlin EL (2017)	1
LGALS8	4	ITGB1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hadari YR (2000), Hadari YR (2000), Huttlin EL (2015), Huttlin EL (2017)	4
VCL	6	DAG1	3	fluorescent resonance energy transfe, affinity chromatography technology	Cerecedo D (2008), Cerecedo D (2008)	2
DMD	6	DAG1	3	x-ray crystallography, affinity chromatography technology	Huang X (2000), Jung D (1995)	2
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
ELAVL1	0	KRAS	1	affinity chromatography technology	Abdelmohsen K (2009)	1
VCL	6	TLN1	5	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CSK	3	CLIC4	3	biochemical	Wan C (2015)	1
LGALS8	4	DAG1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACTN1	5	TUBA1A	13	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Cerecedo D (2008), Cerecedo D (2008), Cerecedo D (2008)	3
FYN	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
DNAJB1	1	DAG1	3	biochemical	Wan C (2015)	1
CDH1	4	UTRN	6	bioid	Guo Z (2014)	1
TCTN2	2	ITGB1	4	bioid	Gupta GD (2015)	1
KRAS	1	DAG1	3	genetic interference	Luo J (2009)	1
CDH1	4	ACTN1	5	affinity chromatography technology	Hazan RB (1998)	1
DAG1	3	AGRN	11	far western blotting	Gee SH (1994)	1
KRAS	1	WWC1	5	genetic interference	Luo J (2009)	1
CEACAM21	1	DAG1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DAG1	3	SHC1	0	pull down, affinity chromatography technology	Sotgia F (2001), Sotgia F (2001)	2
TUBA1A	13	DAG1	3	fluorescent resonance energy transfe, affinity chromatography technology, pull down	Cerecedo D (2008), Cerecedo D (2008), Cerecedo D (2008)	3
HTR3C	2	DAG1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	CLIC4	3	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	FKBP9	1	affinity chromatography technology	Abdelmohsen K (2009)	1
FYN	1	CDH1	4	affinity chromatography technology, pull down	Piedra J (2003), Piedra J (2003)	2
PCDHB11	0	DAG1	3	affinity chromatography technology	Huttlin EL (2017)	1
TNF	0	DAG1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SHC1	0	SRC	2	pull down	Schueller AC (2008)	1
ELAVL1	0	TNF	0	affinity chromatography technology	Xin H (2011)	1
DRP2	0	PRX	3	pull down, affinity chromatography technology	Sherman DL (2001), Sherman DL (2001)	2
ELAVL1	0	CSK	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CEACAM21	1	SRC	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	DMD	6	affinity chromatography technology	Choudhury NR (2017)	1
RAPSN	2	DAG1	3	imaging technique	Apel ED (1995)	1
SRC	2	TLN1	5	affinity chromatography technology	Lee J (2013)	1
CDH1	4	TLN1	5	bioid	Guo Z (2014)	1
GRB2	2	CSK	3	affinity chromatography technology	Bisson N (2011)	1
DRP2	0	DAG1	3	two hybrid	Sherman DL (2001)	1
PCDHGA5	2	DAG1	3	affinity chromatography technology	Huttlin EL (2017)	1