Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
CYP11B2	1585	METOCLOPRAMIDE	CHEMBL86		NCI	7883831
CYP11B2	1585	OSILODROSTAT	CHEMBL3099695	inhibitor	GuideToPharmacologyInteractions
CYP11B2	1585	SPIRONOLACTONE	CHEMBL1393	antagonist	DrugBank	976190
CYP11B2	1585	FADROZOLE	CHEMBL9298	inhibitor	GuideToPharmacologyInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
CYP11B2	rs1799998	GG	candesartan	efficacy	yes	A positive response was defined as a diastolic blood pressure of < 85 mmHg after 4 weeks of treatment. Please note alleles have been complemented to the plus chromosomal strand.	Genotype GG is associated with increased response to candesartan in people with Hypertension as compared to genotypes AA + AG.	12065207	982034045
CYP11B2	rs1799998	GG	irbesartan	efficacy	no	Only a p-value < 0.01 was considered significant in order to account for multiple testing. No differences in the change in systolic blood pressure (SBP) or diastolic blood pressure (DBP) was seen between genotypes, between baseline and 12 weeks of treatment. ANOVA was used, so p-value refers to associations when comparing all three genotypes against each other. Please note alleles have been complemented to the plus chromosomal strand.	Genotype GG is not associated with response to irbesartan in people with Hypertension as compared to genotypes AA + AG.	14700505	982043071
CYP11B2	rs1799998	AA + AG	benazepril	efficacy	yes	Carriers of the A allele had greater reductions in diastolic blood pressure after 6 weeks of treatment compared to GG homozygotes. Please note alleles have been complemented to the plus chromosomal strand.	Genotypes AA + AG are associated with increased response to benazepril or imidapril in people with Essential hypertension as compared to genotype GG.	16765146	982036232
CYP11B2	rs1799998	AA + AG	benazepril	efficacy	no	No significant differences in change of systolic blood pressure over 6 weeks of treatment were seen between genotypes. Please note alleles have been complemented to the plus chromosomal strand.	Genotypes AA + AG are not associated with response to benazepril or imidapril in people with Essential hypertension as compared to genotype GG.	16765146	982036265
CYP11B2	rs1799998	GG	atenolol	efficacy	no	No differences in the change in systolic blood pressure (SBP) or diastolic blood pressure (DBP) was seen between genotypes, between baseline and 12 weeks of treatment. ANOVA was used, so p-value refers to associations when comparing all three genotypes against each other. Please note alleles have been complemented to the plus chromosomal strand.	Genotype GG is not associated with response to atenolol in people with Hypertension as compared to genotypes AA + AG.	14700505	982042981