PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMAD1	0	SKIL	3	affinity chromatography technology	Mizuide M (2003)	1
CEP135	2	CAMSAP1	5	bioid	Gupta GD (2015)	1
CEP135	2	KIAA0753	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
ODF2	1	KIAA0753	1	bioid	Gupta GD (2015)	1
CEP120	5	MED4	2	bioid	Gupta GD (2015)	1
MED4	2	KIAA0753	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
SRPK2	1	CAMSAP1	5	enzymatic study	Lipp JJ (2015)	1
SRPK2	1	CEP170	4	enzymatic study	Lipp JJ (2015)	1
SPICE1	2	CAMSAP1	5	bioid	Gupta GD (2015)	1
LCA5	1	CEP120	5	bioid	Gupta GD (2015)	1
CEP104	4	CEP162	3	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CENPJ	6	CAMSAP1	5	bioid	Gupta GD (2015)	1
CEP120	5	CAMSAP1	5	bioid	Gupta GD (2015)	1
SSX2IP	0	CAMSAP1	5	bioid	Gupta GD (2015)	1
CEP162	3	CEP170	4	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CENPJ	6	SSX2IP	0	bioid	Gupta GD (2015)	1
MED4	2	PCM1	5	bioid, affinity chromatography technology, affinity chromatography technology, bioid	Lambert JP (2015), Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	4
CEP128	1	CEP170	4	bioid	Gupta GD (2015)	1
LCA5	1	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
NTRK1	1	SRPK2	1	affinity chromatography technology	Emdal KB (2015)	1
KIAA0753	1	CEP44	2	bioid	Gupta GD (2015)	1
LCA5	1	CEP170	4	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
CEP104	4	SSX2IP	0	bioid	Gupta GD (2015)	1
CEP120	5	CEP170	4	bioid	Gupta GD (2015)	1
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
LCA5	1	CEP44	2	bioid	Gupta GD (2015)	1
SMAD9	0	CEP135	2	two hybrid	Colland F (2004)	1
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
PCM1	5	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CEP120	5	bioid	Gupta GD (2015)	1
PCM1	5	CEP170	4	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
SPICE1	2	CEP44	2	bioid	Gupta GD (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
RBPJ	1	CAMSAP1	5	affinity chromatography technology	Li X (2015)	1
PCM1	5	KIAA0753	1	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
LCA5	1	CEP162	3	bioid	Gupta GD (2015)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CENPJ	6	CEP170	4	bioid	Gupta GD (2015)	1
SMAD1	0	CAMSAP1	5	two hybrid	Colland F (2004)	1
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
NINL	1	CEP170	4	bioid	Gupta GD (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
SMAD9	0	CAMSAP1	5	two hybrid	Colland F (2004)	1
NINL	1	CEP162	3	bioid	Gupta GD (2015)	1
CEP162	3	CEP120	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
SPICE1	2	KIAA0753	1	bioid	Gupta GD (2015)	1
LCA5	1	CAMSAP1	5	bioid	Gupta GD (2015)	1
SSX2IP	0	KIAA0753	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MED4	2	CEP135	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
NTRK1	1	CAMSAP1	5	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	CENPJ	6	affinity chromatography technology	Rodriguez J (2016)	1
ODF2	1	CEP170	4	bioid	Gupta GD (2015)	1
ODF2	1	SSX2IP	0	bioid	Gupta GD (2015)	1
ODF2	1	CAMSAP1	5	bioid	Gupta GD (2015)	1
MED4	2	CAMSAP1	5	bioid	Lambert JP (2015)	1
DCTN1	6	CAMSAP1	5	bioid	Gupta GD (2015)	1
CEP135	2	CEP44	2	bioid	Gupta GD (2015)	1
CEP128	1	MED4	2	bioid	Gupta GD (2015)	1
CEP162	3	KIAA0753	1	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
SPICE1	2	SSX2IP	0	bioid	Gupta GD (2015)	1
KIAA0753	1	CEP170	4	bioid	Gupta GD (2015)	1
NTRK1	1	PCM1	5	affinity chromatography technology	Emdal KB (2015)	1
NINL	1	PCM1	5	bioid	Gupta GD (2015)	1
CEP104	4	CAMSAP1	5	bioid	Gupta GD (2015)	1
NINL	1	DCTN1	6	affinity chromatography technology	Boldt K (2016)	1
CEP128	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP170	4	DCTN1	6	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CENPJ	6	KIAA0753	1	bioid	Gupta GD (2015)	1
CEP44	2	CAMSAP1	5	bioid	Gupta GD (2015)	1
EGLN3	0	DCTN1	6	affinity chromatography technology	Rodriguez J (2016)	1
CEP120	5	SSX2IP	0	bioid	Gupta GD (2015)	1
CEP162	3	SPICE1	2	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
CEP162	3	CAMSAP1	5	bioid	Gupta GD (2015)	1
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
NINL	1	CENPJ	6	bioid	Gupta GD (2015)	1
ODF2	1	CEP120	5	bioid	Gupta GD (2015)	1
SKIL	3	CAMSAP1	5	two hybrid	Colland F (2004)	1
CEP128	1	CEP44	2	bioid	Gupta GD (2015)	1
LCA5	1	MED4	2	bioid	Gupta GD (2015)	1
CENPJ	6	CEP120	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
NINL	1	CAMSAP1	5	bioid	Gupta GD (2015)	1
PCM1	5	CENPJ	6	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
NTRK1	1	CEP170	4	affinity chromatography technology	Emdal KB (2015)	1
CEP104	4	CEP170	4	bioid	Gupta GD (2015)	1
KIAA0753	1	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
NTRK1	1	DCTN1	6	affinity chromatography technology	Emdal KB (2015)	1
CEP135	2	SSX2IP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP170	4	CAMSAP1	5	bioid	Gupta GD (2015)	1
EGLN3	0	PCM1	5	affinity chromatography technology	Rodriguez J (2016)	1
CEP128	1	CAMSAP1	5	bioid	Gupta GD (2015)	1
CEP44	2	CEP170	4	bioid	Gupta GD (2015)	1
POC1A	3	CAMSAP1	5	bioid	Gupta GD (2015)	1
SRPK2	1	LCA5	1	enzymatic study	Varjosalo M (2013)	1
POC1A	3	CEP44	2	bioid	Gupta GD (2015)	1
KIAA0753	1	CAMSAP1	5	bioid	Gupta GD (2015)	1
MED4	2	SSX2IP	0	bioid	Lambert JP (2015)	1
DCTN1	6	CEP44	2	bioid	Gupta GD (2015)	1
MED4	2	CEP170	4	bioid	Lambert JP (2015)	1
CEP135	2	CEP170	4	bioid	Gupta GD (2015)	1
LCA5	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
LCA5	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
ODF2	1	CEP44	2	bioid	Gupta GD (2015)	1
EGLN3	0	SSX2IP	0	affinity chromatography technology	Rodriguez J (2016)	1
CEP120	5	SPICE1	2	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	3
CEP128	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
MED4	2	CEP162	3	bioid, affinity chromatography technology, bioid	Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	3
EGLN3	0	CEP170	4	affinity chromatography technology	Rodriguez J (2016)	1
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
PCM1	5	CAMSAP1	5	bioid	Gupta GD (2015)	1
MED4	2	SPICE1	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
CEP162	3	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	CEP120	5	bioid	Gupta GD (2015)	1
NINL	1	KIAA0753	1	bioid	Gupta GD (2015)	1
EGLN3	0	CAMSAP1	5	affinity chromatography technology	Rodriguez J (2016)	1
SPICE1	2	CENPJ	6	bioid	Gupta GD (2015)	1
CEP104	4	PCM1	5	bioid	Gupta GD (2015)	1
MED4	2	ODF2	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
PCM1	5	SSX2IP	0	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4