PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MOV10	6	EHMT2	4	affinity chromatography technology	Castello A (2012)	1
RCOR1	0	HDAC1	4	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Battaglioli E (2002), Gu H (2005), Pflum MK (2001), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Cetinkaya C (2007), Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	15
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
HDAC4	10	SUV39H1	0	affinity chromatography technology	Zhang CL (2002)	1
EHMT2	4	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Bantscheff M (2011)	2
RPGRIP1L	2	ESCO2	2	affinity chromatography technology	Gupta GD (2015)	1
RCOR1	0	YEATS4	0	affinity chromatography technology	Boldt K (2016)	1
SETDB1	3	ESCO2	2	affinity chromatography technology	Kim BJ (2008)	1
CBX8	3	MOV10	6	affinity chromatography technology	Vandamme J (2011)	1
HDAC4	10	ESCO2	2	affinity chromatography technology	Kim BJ (2008)	1
HDAC2	1	SETDB1	3	affinity chromatography technology	Yang L (2003)	1
NXF1	0	S100A4	0	affinity chromatography technology	Castello A (2012)	1
8339	0	YEATS4	0	bioid	Lambert JP (2015)	1
MATR3	2	ESCO2	2	affinity chromatography technology	Hein MY (2015)	1
MOV10	6	ESCO2	2	affinity chromatography technology	Castello A (2012)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
CBX8	3	ESCO2	2	affinity chromatography technology	Vandamme J (2011)	1
NXF1	0	HDAC2	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	8339	0	affinity chromatography technology	Castello A (2012)	1
8339	0	EHMT2	4	bioid	Lambert JP (2015)	1
HDAC1	4	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2003), You A (2001), You A (2001), Shi YJ (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Godmann M (2007), Terhune SS (2010), Godmann M (2010), Godmann M (2010), Wang Y (2009), Nicholson TB (2011), Li Q (2011), Cui S (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Wang Q (2016), Huttlin EL (2017)	26
EHMT2	4	ESCO2	2	affinity chromatography technology	Kim BJ (2008)	1
SUV39H1	0	HDAC2	1	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
YEATS4	0	KDM1A	2	two hybrid, two hybrid, affinity chromatography technology	Piccinni E (2011), Piccinni E (2011), Boldt K (2016)	3
HDAC2	1	ESCO2	2	affinity chromatography technology	Kim BJ (2008)	1
PHF21A	4	YEATS4	0	affinity chromatography technology	Boldt K (2016)	1
SUV39H1	0	ESCO2	2	affinity chromatography technology	Kim BJ (2008)	1
MOV10	6	HDAC2	1	affinity chromatography technology	Castello A (2012)	1
PHF21A	4	HDAC1	4	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Iwase S (2004), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	5
NXF1	0	ESCO2	2	affinity chromatography technology	Castello A (2012)	1
NCAPD3	6	ESCO2	2	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	EHMT2	4	affinity chromatography technology	Castello A (2012)	1
YEATS4	0	ESCO2	2	affinity chromatography technology	Hein MY (2015)	1
USF1	0	ESCO2	2	affinity chromatography technology	Hein MY (2015)	1
ESCO2	2	RCOR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BJ (2008), Kim BJ (2008), Choi HK (2010)	3
HDAC2	1	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, genetic interference	Hakimi MA (2002), Hakimi MA (2003), Hakimi MA (2003), Hakimi MA (2003), Tong JK (1998), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Wang Y (2009), Li Q (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Wong AS (2016)	17
CBX8	3	SETDB1	3	two hybrid	Stelzl U (2005)	1
HDAC1	4	EHMT2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	3
SUV39H1	0	SETDB1	3	affinity chromatography technology	Huttlin EL (2017)	1
NXF1	0	RPGRIP1L	2	affinity chromatography technology, bioid	Castello A (2012), Gupta GD (2015)	2
PHF21A	4	HDAC2	1	biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Iwase S (2004), Hakimi MA (2003), Joshi P (2013)	4
8339	0	ESCO2	2	bioid	Lambert JP (2015)	1
NXF1	0	NCAPD3	6	affinity chromatography technology	Castello A (2012)	1
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
RPGRIP1L	2	KDM1A	2	bioid	Gupta GD (2015)	1
SUV39H1	0	EHMT2	4	affinity chromatography technology	Huttlin EL (2017)	1
RCOR1	0	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Battaglioli E (2002), Humphrey GW (2001), Humphrey GW (2001), Bantscheff M (2011), Joshi P (2013)	8
SUV39H1	0	HDAC1	4	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
PHF21A	4	RCOR1	0	biochemical, pull down, affinity chromatography technology	Hakimi MA (2002), Iwase S (2004), Boldt K (2016)	3
MOV10	6	NCAPD3	6	affinity chromatography technology	Castello A (2012)	1
NXF1	0	SETDB1	3	affinity chromatography technology	Castello A (2012)	1
HDAC1	4	ESCO2	2	affinity chromatography technology	Kim BJ (2008)	1
KDM1A	2	ESCO2	2	affinity chromatography technology	Kim BJ (2008)	1
MOV10	6	SETDB1	3	affinity chromatography technology	Castello A (2012)	1
PHF21A	4	ESCO2	2	affinity chromatography technology	Kim BJ (2008)	1
MOV10	6	S100A4	0	affinity chromatography technology	Castello A (2012)	1
PHF21A	4	KDM1A	2	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Iwase S (2004), Hakimi MA (2003), Shi YJ (2005), Lee MG (2005), Boldt K (2016)	6
S100A4	0	ESCO2	2	affinity chromatography technology	Hein MY (2015)	1
S100A4	0	SUV39H1	0	affinity chromatography technology	Hein MY (2015)	1
8339	0	CBX8	3	bioid	Lambert JP (2015)	1
KDM1A	2	SETDB1	3	two hybrid	Stelzl U (2005)	1