PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CYP2E1	0	ECHS1	2	two hybrid	Wang J (2011)	1
CLU	1	CYP2E1	0	two hybrid	Wang J (2011)	1
STUB1	4	CYP2E1	0	enzymatic study	Wang Y (2011)	1
CYB5A	1	CYP2E1	0	pull down	Shimada T (2005)	1
CYP2E1	0	GATM	0	two hybrid	Wang J (2011)	1
CYP2E1	0	POLR3E	1	affinity chromatography technology	Huttlin EL (2017)	1
FANCG	3	CYP2E1	0	two hybrid, two hybrid, pull down	Reuter TY (2003), Futaki M (2002), Futaki M (2002)	3
POR	1	CYP2E1	0	pull down, pull down, pull down, protein complementation assay	Guengerich FP (1997), Shimada T (2005), Shimada T (2005), Ozalp C (2005)	4
AMFR	2	CYP2E1	0	enzymatic study	Wang Y (2011)	1
AGXT2	1	CYP2E1	0	two hybrid	Wang J (2011)	1
CYP2E1	0	RPL13A	2	two hybrid	Wang J (2011)	1
CYP2E1	0	RMDN1	0	affinity chromatography technology	Huttlin EL (2017)	1
CYP2E1	0	NMI	3	two hybrid	Wang J (2011)	1
CYP2E1	0	MAFG	1	two hybrid	Wang J (2011)	1
CYP2E1	0	PTN	0	two hybrid	Wang J (2011)	1
ABCA5	8	CYP2E1	0	two hybrid	Wang J (2011)	1
CYP2E1	0	LAMC3	9	two hybrid	Wang J (2011)	1