PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NUP62	1	AGR3	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
AGR3	2	DAG1	3	two hybrid	Fletcher GC (2003)	1
CASP8	1	LYPD3	0	two hybrid	Arroyo R (2015)	1
AGR3	2	ASB10	3	two hybrid	Wang J (2011)	1
PTPN1	2	AGR3	2	two hybrid	Arroyo R (2015)	1
AKT1	1	AGR3	2	two hybrid	Arroyo R (2015)	1
UBQLN1	1	AGR3	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SGTA	1	AGR3	2	two hybrid	Rolland T (2014)	1
BCAR3	5	AGR3	2	two hybrid	Arroyo R (2015)	1
ERLIN1	3	AGR3	2	two hybrid	Rolland T (2014)	1
LYPD3	0	PTPN1	2	affinity chromatography technology	Huttlin EL (2015)	1
APC	5	AGR3	2	two hybrid	Arroyo R (2015)	1
CASP8	1	AGR3	2	two hybrid	Arroyo R (2015)	1
ESR2	1	AGR3	2	two hybrid	Arroyo R (2015)	1
AGR3	2	LYPD3	0	two hybrid	Fletcher GC (2003)	1
TGFB1	2	AGR3	2	two hybrid	Arroyo R (2015)	1