PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADRB2	0	GNB4	2	affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013)	2
ADRB2	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Nabhan JF (2010), Han SO (2012)	2
ADRB2	0	GPRC5B	3	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ADRB2	0	GNAT2	0	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ADRB2	0	ARRDC1	4	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Patwari P (2011)	2
ADRB2	0	ADGRG1	3	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ARRDC3	0	ARRB2	5	affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Han SO (2012)	2
ADRB2	0	SLC9A3R2	8	pull down, affinity chromatography technology	Hall RA (1998), Roy SJ (2013)	2
ADRB2	0	RGS11	0	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
JKAMP	0	RNF5	0	affinity chromatography technology, enzymatic study	Tcherpakov M (2009), Tcherpakov M (2009)	2
ADRB2	0	RGS10	0	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ADRB2	0	MAPK8IP2	5	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
AMFR	2	RNF5	0	affinity chromatography technology	Morito D (2008)	1
EGLN3	0	VDAC2	1	affinity chromatography technology	Rodriguez J (2016)	1
ADRB2	0	WNK1	7	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
EGLN3	0	GNB1	4	affinity chromatography technology	Rodriguez J (2016)	1
ADRB2	0	USP20	3	affinity chromatography technology, affinity chromatography technology	Han SO (2012), Kommaddi RP (2015)	2
ADRB2	0	ADCY3	5	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
GNB1	4	GNAS	9	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Huttlin EL (2015), Huttlin EL (2017)	3
ADRB2	0	RNF5	0	affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013)	2
ADRB2	0	KCTD13	1	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ADRB2	0	ARHGDIA	3	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ADRB2	0	KCNE1	0	protein complementation assay, affinity chromatography technology, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014), Kittanakom S (2014)	3
SLC9A3R1	2	ADRB2	0	x-ray crystallography, pull down, pull down, affinity chromatography technology	Karthikeyan S (2002), Hall RA (1998), Hall RA (1998), Xu J (2001)	4
ADRB2	0	ARRDC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Nabhan JF (2010), Shea FF (2012), Qi S (2014), Patwari P (2011), Shea FF (2012), Tian X (2016), Tian X (2016), Tian X (2016)	8
ARRB2	5	ADGRG1	3	affinity chromatography technology	Paavola KJ (2011)	1
ADRB2	0	ALDOA	0	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
CD81	0	RACK1	2	affinity chromatography technology	Perez-Hernandez D (2013)	1
ADRB2	0	GNAS	9	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Roy SJ (2013), Feldman DS (2002)	3
ADRB2	0	STAT4	3	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ADRB2	0	VDAC2	1	affinity chromatography technology, protein complementation assay	Roy SJ (2013), Kittanakom S (2014)	2
ADRB2	0	CD81	0	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
EGLN3	0	GNAS	9	affinity chromatography technology	Rodriguez J (2016)	1
ADRB2	0	4985	0	affinity chromatography technology, fluorescent resonance energy transfe	McVey M (2001), McVey M (2001)	2
ARRB2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Han SO (2012)	2
ADRB2	0	GNB1	4	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Roy SJ (2013), Roy SJ (2013)	3
ADRB2	0	CD4	1	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ADRB2	0	IL6R	1	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
EGLN3	0	GRB2	2	affinity chromatography technology	Rodriguez J (2016)	1
JKAMP	0	ADRB2	0	affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013)	2
ADRB2	0	TSHR	1	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
CD4	1	VDAC2	1	affinity chromatography technology	Bernhard OK (2004)	1
RACK1	2	SLC9A3R1	2	affinity chromatography technology	Liedtke CM (2002)	1
RACK1	2	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Chen S (2008), Knezevic N (2009)	3
GNB2	3	GRK2	4	enzymatic study	Zha Z (2015)	1
ADRB2	0	RACK1	2	affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Kittanakom S (2014), Kittanakom S (2014), Kittanakom S (2014)	4
ADRB2	0	CEACAM1	1	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
EGLN3	0	RNF5	0	affinity chromatography technology	Rodriguez J (2016)	1
ADRB2	0	ARHGAP5	3	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ARRDC3	0	NEDD4	2	affinity chromatography technology, imaging technique, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Nabhan JF (2010), Nabhan JF (2010), Qi S (2014), Qi S (2014), Qi S (2014), Huttlin EL (2017)	6
ADRB2	0	AKAP12	4	pull down, affinity chromatography technology, biochemical	Fan G (2001), Fan G (2001), Shih M (1999)	3
ADRB2	0	PLA2G2D	0	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
GRK2	4	GNB1	4	affinity chromatography technology, pull down, affinity chromatography technology	Seo M (2007), Carman CV (2000), Iacovelli L (2004)	3
ADRB2	0	RAN	1	affinity chromatography technology, protein complementation assay	Roy SJ (2013), Kittanakom S (2014)	2
ADRB2	0	MARCH2	2	affinity chromatography technology, imaging technique	Han SO (2012), Han SO (2012)	2
ARRDC1	4	NEDD4	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rauch S (2011), Huttlin EL (2015), Huttlin EL (2017)	3
ADRB2	0	GPR37	3	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
GRK6	3	ADRB2	0	enzymatic study, protein complementation assay, affinity chromatography technology, pull down	Stoffel RH (1998), Kittanakom S (2014), Kittanakom S (2014), Menard L (1996)	4
ADRB2	0	RNF41	2	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
4985	0	ARRB2	5	pull down	Cen B (2001)	1
ADRB2	0	GRK2	4	affinity chromatography technology, enzymatic study, pull down	Fan G (2001), Lorenz K (2003), Menard L (1996)	3
ADRB2	0	EGLN3	0	affinity chromatography technology, pull down, pull down	Xie L (2009), Xie L (2009), Xie L (2009)	3
ADRB2	0	MCAM	5	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ADRB2	0	CD68	1	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
ADRB2	0	CD9	1	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
GNAS	9	GNB4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ADRB2	0	GRB2	2	affinity chromatography technology, pull down	Karoor V (1998), Karoor V (1998)	2
CD4	1	CD81	0	affinity chromatography technology	Imai T (1995)	1
ADRB2	0	ARRB2	5	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Kittanakom S (2014), Tian X (2016), Tian X (2016)	3
ADRB2	0	AMFR	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013), Roy SJ (2013)	3
ARHGDIA	3	ALDOA	0	biochemical	Wan C (2015)	1
CD81	0	CD9	1	affinity chromatography technology, biochemical	Radford KJ (1996), Horvath G (1998)	2
GNAS	9	GNB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ADRB2	0	GNB2	3	affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013)	2