PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UPF2	2	CYBA	0	two hybrid	Lehner B (2004)	1
CYBA	0	RBPMS	0	two hybrid	Rolland T (2014)	1
CYBA	0	RCHY1	0	two hybrid	Wang J (2011)	1
CYBA	0	MDFI	1	two hybrid	Venkatesan K (2009)	1
NCF2	0	NCF1	2	pull down, pull down, far western blotting, pull down, unspecified method, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology	Lapouge K (2002), Leto TL (1994), Leto TL (1994), Rinckel LA (1999), Dahan I (2002), Kami K (2002), Kami K (2002), Takeshita F (2005), Marty C (2006), Marty C (2006)	10
CYBA	0	PSMA3	1	two hybrid	Rolland T (2014)	1
NCF2	0	CYBA	0	pull down, unspecified method	Dang PM (2002), Dahan I (2002)	2
VHL	0	RBPMS	0	pull down	Lai Y (2012)	1
CYBA	0	VHL	0	affinity chromatography technology	Block K (2007)	1
MDFI	1	VHL	0	two hybrid	Rolland T (2014)	1
NCF1	2	CYBA	0	pull down, pull down	Leto TL (1994), Fontayne A (2002)	2
SLC2A12	2	CYBA	0	affinity chromatography technology	Huttlin EL (2017)	1
CPT1A	1	CYBA	0	two hybrid	Wang J (2011)	1